Poor Cosmetic Ingredient

Peganum Harmala Seed Extract ⚠️

INCI: PEGANUM HARMALA SEED EXTRACT

CAS Number
Not assigned in CosIng
Function
Skin conditioning
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA: no specific cosmetic restriction; plant classified as noxious weed in AZ, CA, CO, NV, NM, OR; alkaloids regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Contains 4–6% β-carboline alkaloids (harmine, harmaline) confirmed as MAO inhibitors with mutagenic and teratogenic effects in animal models; alkaloids illegal in France, Canada, Australia; no established safe cosmetic concentration.

⚠️
Concern Level: High

Regulatory Flags

plant-extract peg-ingredient

Frequently Asked Questions

Is Peganum Harmala Seed Extract ⚠️ safe in cosmetics?

Contains 4–6% β-carboline alkaloids (harmine, harmaline) confirmed as MAO inhibitors with mutagenic and teratogenic effects in animal models; alkaloids illegal in France, Canada, Australia; no established safe cosmetic concentration. The EU classifies Peganum Harmala Seed Extract ⚠️ as "permitted". Safety rating: POOR.

Is Peganum Harmala Seed Extract ⚠️ allowed in the EU?

Peganum Harmala Seed Extract ⚠️ EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Peganum Harmala Seed Extract ⚠️ do in cosmetics?

Peganum Harmala Seed Extract ⚠️ functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned in CosIng.

What is the Margin of Safety for Peganum Harmala Seed Extract ⚠️?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Peganum Harmala Seed Extract ⚠️ compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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