Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Pentadecalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Prohibited in EU due to screening-level PEC/PNEC ratio exceeding 1 for aquatic environment, indicating possible environmental risk, though not classified as PBT or vPvB per IFRA Environmental Standards. Permitted in US as safe per RIFM/Expert Panel.
Regulatory Flags
Frequently Asked Questions
Is Pentadecalactone safe in cosmetics?
Prohibited in EU due to screening-level PEC/PNEC ratio exceeding 1 for aquatic environment, indicating possible environmental risk, though not classified as PBT or vPvB per IFRA Environmental Standards. Permitted in US as safe per RIFM/Expert Panel. The EU classifies Pentadecalactone as "prohibited". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Pentadecalactone allowed in the EU?
Pentadecalactone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Pentadecalactone do in cosmetics?
Pentadecalactone functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 106-02-5.
What is the Margin of Safety for Pentadecalactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Pentadecalactone?
The NOAEL (No Observed Adverse Effect Level) for Pentadecalactone is >=1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
Check Pentadecalactone compliance across multiple jurisdictions:
Related Ingredients
Is Pentadecalactone in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Pentadecalactone in your formulation.