Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Pentaerythritol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
No significant safety concerns; ensure cosmetic-grade purity with formaldehyde residuals controlled below established limits.
Frequently Asked Questions
Is Pentaerythritol safe in cosmetics?
No significant safety concerns; ensure cosmetic-grade purity with formaldehyde residuals controlled below established limits. The EU classifies Pentaerythritol as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Pentaerythritol allowed in the EU?
Pentaerythritol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pentaerythritol do in cosmetics?
Pentaerythritol functions as: Humectant, viscosity controlling agent, chemical intermediate/building block. It is classified as a cosmetic ingredient in our database. CAS number: 115-77-5.
What is the Margin of Safety for Pentaerythritol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Pentaerythritol?
The NOAEL (No Observed Adverse Effect Level) for Pentaerythritol is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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