Pentaerythrityl Tetramercaptobutyrate

INCI: PENTAERYTHRITYL TETRAMERCAPTOBUTYRATE

CAS Number
72244-98-5
Function
Film forming (nail products — thiol-ene crosslinker)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not CIR-reviewed; no FDA monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No published cosmetic safety data available; thiol groups are highly reactive and protein-binding with sensitization mechanism; strong unpleasant odor; industrial crosslinker with limited cosmetic precedent; CLP classification by analogy would include Acute Tox. 4, Skin Sens. 1A, Skin Irrit. 2, and Eye Irrit. 2.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Pentaerythrityl Tetramercaptobutyrate safe in cosmetics?

No published cosmetic safety data available; thiol groups are highly reactive and protein-binding with sensitization mechanism; strong unpleasant odor; industrial crosslinker with limited cosmetic precedent; CLP classification by analogy would include Acute Tox. 4, Skin Sens. 1A, Skin Irrit. 2, and Eye Irrit. 2. The EU classifies Pentaerythrityl Tetramercaptobutyrate as "permitted". Safety rating: POOR.

Is Pentaerythrityl Tetramercaptobutyrate allowed in the EU?

Pentaerythrityl Tetramercaptobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pentaerythrityl Tetramercaptobutyrate do in cosmetics?

Pentaerythrityl Tetramercaptobutyrate functions as: Film forming (nail products — thiol-ene crosslinker). It is classified as a cosmetic ingredient in our database. CAS number: 72244-98-5.

What is the Margin of Safety for Pentaerythrityl Tetramercaptobutyrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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