Halocidin Subunit A Amide / Halocidin Subunit B Amide

INCI: HALOCIDIN SUBUNIT A AMIDE/HALOCIDIN SUBUNIT B AMIDE

CAS Number
452722-04-4 (parent halocidin)
Function
Antimicrobial peptide derived from tunicate (Halocynthia aurantium) hemocytes; two disulfide-linked subunits
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Permitted โ€” not listed as prohibited/restricted under 21 CFR; antimicrobial function may trigger preservative classification scrutiny

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Published antifungal activity against Candida albicans and antibacterial properties. No CIR or SCCS assessment. Peptide stability in formulation and potential for degradation products must be evaluated. If claimed as a preservative booster, functional classification review is needed.

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Concern Level: Moderate

Frequently Asked Questions

Is Halocidin Subunit A Amide / Halocidin Subunit B Amide safe in cosmetics?

Published antifungal activity against Candida albicans and antibacterial properties. No CIR or SCCS assessment. Peptide stability in formulation and potential for degradation products must be evaluated. If claimed as a preservative booster, functional classification review is needed. The EU classifies Halocidin Subunit A Amide / Halocidin Subunit B Amide as "permitted". Safety rating: MODERATE.

Is Halocidin Subunit A Amide / Halocidin Subunit B Amide allowed in the EU?

Halocidin Subunit A Amide / Halocidin Subunit B Amide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Halocidin Subunit A Amide / Halocidin Subunit B Amide do in cosmetics?

Halocidin Subunit A Amide / Halocidin Subunit B Amide functions as: Antimicrobial peptide derived from tunicate (Halocynthia aurantium) hemocytes; two disulfide-linked subunits. It is classified as a cosmetic ingredient in our database. CAS number: 452722-04-4 (parent halocidin).

What is the Margin of Safety for Halocidin Subunit A Amide / Halocidin Subunit B Amide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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