Pentaerythrityl Tetramercaptopropionate

INCI: PENTAERYTHRITYL TETRAMERCAPTOPROPIONATE

CAS Number
7575-23-7
Function
Film forming (nail gel products — thiol-ene crosslinker)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Not CIR-reviewed; permitted in nail products under general FDA cosmetics provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CRITICAL: Used at 10–16% in nail gel products where it becomes polymerized upon UV cure; uncured monomer is a potent sensitizer; must be fully cured to be safe; contraindicated for skin-contact leave-on products; strong thiol odor

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Pentaerythrityl Tetramercaptopropionate safe in cosmetics?

CRITICAL: Used at 10–16% in nail gel products where it becomes polymerized upon UV cure; uncured monomer is a potent sensitizer; must be fully cured to be safe; contraindicated for skin-contact leave-on products; strong thiol odor The EU classifies Pentaerythrityl Tetramercaptopropionate as "restricted". Safety rating: POOR.

Is Pentaerythrityl Tetramercaptopropionate allowed in the EU?

Pentaerythrityl Tetramercaptopropionate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pentaerythrityl Tetramercaptopropionate do in cosmetics?

Pentaerythrityl Tetramercaptopropionate functions as: Film forming (nail gel products — thiol-ene crosslinker). It is classified as a cosmetic ingredient in our database. CAS number: 7575-23-7.

What is the Margin of Safety for Pentaerythrityl Tetramercaptopropionate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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