NOAEL Studies
Cosmetic Ingredient
Pentane NOAEL Studies
INCI: PENTANE
CAS: 109-66-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=0748292b-8f1b-447d-992a-8e01287758e2.i6z; document=ffdad6fd-9347-43f1-9271-5e0c5f08c187_0748292b-8f1b-447d-992a-8e01287758e2.i6d; document_key=ffdad6fd-9347-43f1-9271-5e0c5f08c187/0748292b-8f1b-447d-992a-8e01287758e2; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1997; ReportDate=1997-04-10; basis=other:; key_result=true; entry_uuid=78df5eb9-9b02-45fa-9e3f-d0807126d3f5 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=0748292b-8f1b-447d-992a-8e01287758e2.i6z; document=cbac1dfd-6ac0-4561-be43-009f1c46bef0_0748292b-8f1b-447d-992a-8e01287758e2.i6d; document_key=cbac1dfd-6ac0-4561-be43-009f1c46bef0/0748292b-8f1b-447d-992a-8e01287758e2; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=other:; key_result=true; entry_uuid=1cb97ad9-7510-4fa6-a9b8-5c501cfc5988 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=0748292b-8f1b-447d-992a-8e01287758e2.i6z; document=ffdad6fd-9347-43f1-9271-5e0c5f08c187_0748292b-8f1b-447d-992a-8e01287758e2.i6d; document_key=ffdad6fd-9347-43f1-9271-5e0c5f08c187/0748292b-8f1b-447d-992a-8e01287758e2; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1997; ReportDate=1997-04-10; basis=other:; key_result=true; entry_uuid=78df5eb9-9b02-45fa-9e3f-d0807126d3f5 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=0748292b-8f1b-447d-992a-8e01287758e2.i6z; document=cbac1dfd-6ac0-4561-be43-009f1c46bef0_0748292b-8f1b-447d-992a-8e01287758e2.i6d; document_key=cbac1dfd-6ac0-4561-be43-009f1c46bef0/0748292b-8f1b-447d-992a-8e01287758e2; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=other:; key_result=true; entry_uuid=1cb97ad9-7510-4fa6-a9b8-5c501cfc5988 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=0748292b-8f1b-447d-992a-8e01287758e2.i6z; document=ffdad6fd-9347-43f1-9271-5e0c5f08c187_0748292b-8f1b-447d-992a-8e01287758e2.i6d; document_key=ffdad6fd-9347-43f1-9271-5e0c5f08c187/0748292b-8f1b-447d-992a-8e01287758e2; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1997; ReportDate=1997-04-10; basis=other:; key_result=true; entry_uuid=78df5eb9-9b02-45fa-9e3f-d0807126d3f5 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=0748292b-8f1b-447d-992a-8e01287758e2.i6z; document=cbac1dfd-6ac0-4561-be43-009f1c46bef0_0748292b-8f1b-447d-992a-8e01287758e2.i6d; document_key=cbac1dfd-6ac0-4561-be43-009f1c46bef0/0748292b-8f1b-447d-992a-8e01287758e2; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=other:; key_result=true; entry_uuid=1cb97ad9-7510-4fa6-a9b8-5c501cfc5988 |
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 364 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1487; Record_ID=acute_inhalation_1156; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2025846; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=364; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025846; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025846 |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_860; row=4176; data_type=In Vivo; mixture=Chemical; chemical_name=Pentane; preferred_name=Pentane; dtxsid=DTXSID2025846; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025846; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025846; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_861; row=4177; data_type=In Vivo; mixture=Chemical; chemical_name=Pentane; preferred_name=Pentane; dtxsid=DTXSID2025846; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025846; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025846; source_file=acute_oral.xlsx |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =44264.6 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=DOE Protective Action Criteria:15518223:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_274104e459aadd486b633f4b4f65c6d7 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =3000 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634005:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64fabbe261c2a7ce5e822d4a4c874ac8 |
ToxValDB_PPRTV_(CPHEA) 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | NOAEL (HEC) | =3658 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=McKee et al. 1998; AUTHOR=McKee et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b85d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1842; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=PPRTV (CPHEA):15653752:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ebe89bcddd68259bb3759a13c1e3757c |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=McKee et al. 1998; AUTHOR=McKee et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b85d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1842; TOXICOLOGICAL_EFFECT=No effects in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653750_15653751:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7acee53ca77e932ab0090562e807a287 |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =10 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=McKee et al. 1998; AUTHOR=McKee et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b85d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1842; TOXICOLOGICAL_EFFECT=No effects in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653750_15653751:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_561b065458d46c000ca54b7378c7498e |
ToxValDB_TX_TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | NOAEL | =8852.93 | mg/m3 | Rat | inhalation | chronic; 30 weeks | chronic | LONG_REF=Frontali N, MC Amantini, A Spagnolo et al. 1981. Experimental neurotoxicity and urinary metabolites of the C5-C7 aliphatic hydrocarbons used as glue solvents in shoe manufacture. Clin Toxicol 18: 1357-136.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ad7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/pentane.pdf; YEAR=2011 Accessible 2013; ORIGINAL_YEAR=2011 Accessible 2013; TOXICOLOGICAL_EFFECT=neurotoxic effects; STUDY_GROUP=TX TCEQ:15954607:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_079d613bd685b98cd503ae273c4323c5 |
| ToxValDB_TX_TCEQ | NOAEL | =19936.8 | mg/m3 | Rat | inhalation | short-term; 3 days | short-term | LONG_REF=Lammers J, H Muijse, D Owen et al. 2011. Neurobehavioral effects of acute exposures to (n-) paraffins. Int J Toxicol 30(1):47-58; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ad7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/pentane.pdf; YEAR=2011 Accessible 2013; ORIGINAL_YEAR=2011 Accessible 2013; TOXICOLOGICAL_EFFECT=neurobehavioral effects; STUDY_GROUP=TX TCEQ:15954608:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_42bcf80fc992c9fb91f2d9e0c11d45a6 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 4FEX897A91 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H12","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4FEX897A91"} |
| openFDA substances | FDA UNII substance identifier | 4FEX897A91 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H12","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4FEX897A91"} |
| openFDA substances | FDA UNII substance identifier | 4FEX897A91 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H12","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4FEX897A91"} |
| openFDA substances | FDA UNII substance identifier | 4FEX897A91 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H12","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4FEX897A91"} |