Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Perhydrol Urea. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 ppm | oral | mouse | oral | REACH |
| NOAEL | 216 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 45000 ppm | oral | mouse | oral | REACH |
| NOAEL | 338.4 mg/kg bw/day | dermal | - | dermal | REACH |
| NOAEL | 45000 ppm | oral | rat | oral | REACH |
| NOAEL | 100 ppm | oral | - | oral | REACH |
| NOAEL | 45000 ppm | oral | - | oral | REACH |
| NOAEL | 45000 ppm | oral | - | oral | REACH |
Expert Verdict
Strong oxidizer incompatible with reducing agents, thiols, and antioxidants; can increase percutaneous absorption of co-formulated ingredients; requires pH control to prevent skin irritation above 4% H₂O₂ concentration.
Frequently Asked Questions
Is Perhydrol Urea safe in cosmetics?
Strong oxidizer incompatible with reducing agents, thiols, and antioxidants; can increase percutaneous absorption of co-formulated ingredients; requires pH control to prevent skin irritation above 4% H₂O₂ concentration. The EU classifies Perhydrol Urea as "restricted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.
Is Perhydrol Urea allowed in the EU?
Perhydrol Urea EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Perhydrol Urea do in cosmetics?
Perhydrol Urea functions as: Oxidizing agent, oral care agent for teeth whitening, hair bleaching auxiliary. It is classified as a cosmetic ingredient in our database. CAS number: 124-43-6.
What is the Margin of Safety for Perhydrol Urea?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Perhydrol Urea?
The NOAEL (No Observed Adverse Effect Level) for Perhydrol Urea is 100 ppm based on a oral study via oral route in mouse. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
Check Perhydrol Urea compliance across multiple jurisdictions:
Related Ingredients
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