NOAEL Studies Cosmetic Ingredient

Phenethyl Acetate NOAEL Studies

INCI: PHENETHYL ACETATE

CAS: 103-45-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >0.5 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4249; Record_ID=acute_inhalation_1080; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7044506; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.5; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044506
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3670 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_330; row=12562; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenylethyl acetate; preferred_name=2-Phenylethyl acetate; dtxsid=DTXSID7044506; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044506; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_332; row=12563; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenylethyl acetate; preferred_name=2-Phenylethyl acetate; dtxsid=DTXSID7044506; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044506; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =5200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_334; row=12564; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenylethyl acetate; preferred_name=2-Phenylethyl acetate; dtxsid=DTXSID7044506; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044506; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2117; Record_ID=skin_sensitization_invivo_616; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7044506; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90203-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044506
NTP_ICE_skin_sensitization Induction dose per skin area 6480 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2116; Record_ID=skin_sensitization_invivo_616; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7044506; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90203-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044506
NTP_ICE_skin_sensitization Induction dose per skin area 1550 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2120; Record_ID=skin_sensitization_invivo_617; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7044506; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1550; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22414644; 10.1016/j.fct.2012.02.089; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044506
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2119; Record_ID=skin_sensitization_invivo_616; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7044506; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90203-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044506
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =6.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634107:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_620e72227c346214b45c09b90dcb0320
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 67733846OW UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"67733846OW"}
openFDA substances FDA UNII substance identifier 67733846OW UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"67733846OW"}
openFDA substances FDA UNII substance identifier 67733846OW UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"67733846OW"}
openFDA substances FDA UNII substance identifier 67733846OW UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"67733846OW"}