NOAEL Studies Cosmetic Ingredient

Phenethyl Isobutyrate NOAEL Studies

INCI: PHENETHYL ISOBUTYRATE

CAS: 103-48-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =5200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_336; row=12571; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenylethyl 2-methylpropanoate; preferred_name=2-Phenylethyl 2-methylpropanoate; dtxsid=DTXSID7044764; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044764; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2125; Record_ID=skin_sensitization_invivo_618; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7044764; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|RIFM 1971; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80142-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044764
NTP_ICE_skin_sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2124; Record_ID=skin_sensitization_invivo_618; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7044764; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|RIFM 1971; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80142-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044764
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2127; Record_ID=skin_sensitization_invivo_618; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7044764; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|RIFM 1971; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80142-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7044764
ToxValDB_EPA_TSCA_8e 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e LOAEL =1000 mg/kg bw/day Rat oral subchronic (developmental) reproduction developmental GUIDELINE=OECD 422; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20652_OECD422_CAS_103-48-0_TSCA8e_summary_2017-1-30_C.pdf; TOXICOLOGICAL_EFFECT=P0: salivation, reduced platelets; STUDY_GROUP=EPA TSCA 8e_dup_-_15956507_15956510_15956511:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ebdb5ef36e60876cf6b4e80886eb5a1a
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =3.53 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634045:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f326ec9e56809b748a02f9575a5191fc
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier QRZ4RE7DCL UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QRZ4RE7DCL"}
openFDA substances FDA UNII substance identifier QRZ4RE7DCL UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QRZ4RE7DCL"}
openFDA substances FDA UNII substance identifier QRZ4RE7DCL UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QRZ4RE7DCL"}
openFDA substances FDA UNII substance identifier QRZ4RE7DCL UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QRZ4RE7DCL"}