NOAEL Studies Cosmetic Ingredient

Piperine NOAEL Studies

INCI: PIPERINE

CAS: 94-62-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 89.1 mg/kg bw/day mouse oral NA Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 350 mg/kg bw/day rat oral 7 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 25 mg/kg bw/day mouse oral 4 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5 mg/kg bw/day rat oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 10 mg/kg bw/day mouse oral 14 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 75 mg/kg bw/day mouse oral 5 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1.12 mg/kg bw/day mouse oral 5 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =5 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2601 - clinical chemistry - systemic - Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting) - doi:10.2903/j.efsa.2015.3998
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =5 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2601 - clinical chemistry - systemic - Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting) - doi:10.2903/j.efsa.2015.3998
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =514 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11603; row=5543; data_type=In Vivo; mixture=Chemical; chemical_name=Piperine; preferred_name=Piperine; dtxsid=DTXSID3021805; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021805; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021805; source_file=acute_oral.xlsx
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =5 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA CEF (2015). Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting). doi:10.2903/j.efsa.2015.3998.; TITLE=Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.3998; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15621567:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3eae68dce81f0870bafe9e3a37c84311
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier U71XL721QK UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H19NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U71XL721QK"}
openFDA substances FDA UNII substance identifier U71XL721QK UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H19NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U71XL721QK"}
openFDA substances FDA UNII substance identifier U71XL721QK UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H19NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U71XL721QK"}
openFDA substances FDA UNII substance identifier U71XL721QK UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H19NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U71XL721QK"}