MODERATE Cosmetic Ingredient NOAEL Data

Piperine

Also known as: Piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, 1-(5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (E,E)-, 1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine, EINECS 202-348-0, FEMA No. 2909 (+8 more)

INCI: PIPERINE

Piperine (CAS 94-62-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning, bioenhancer (increases dermal penetration of co-formulated. NOAEL 5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.

View industrial chemical safety profile for CAS 94-62-2 →

Cross-Vertical Regulatory Divergence

Piperine is classified GHS Danger (H301) in the chemicals database but is allowed in EU cosmetics.

Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code

CAS Number

94-62-2

View industrial chemical safety profile →

Function

Skin conditioning, bioenhancer (increases dermal penetration of co-formulated actives)

Editorial assessment

MODERATE

Preliminary editorial note — not a computed safety verdict.

Chemistry & Identifiers

Formula

C17H19NO3

285.34 g/mol

PubChem CID

638024

IUPAC Name

(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one

InChIKey

MXXWOMGUGJBKIW-YPCIICBESA-N

ChEBI: CHEBI:28821 UNII: U71XL721QK Wikidata: Q414501

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes GRAS for food use (21 CFR); permitted in cosmetics under general provisions

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Piperine.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Piperine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	1.12 mg/kg bw/day	oral	mouse	Short Term Toxicity	COSMOS DB
NOAEL	10 mg/kg bw/day	oral	mouse	Reproductive	COSMOS DB
NOAEL	25 mg/kg bw/day	oral	mouse	Developmental	COSMOS DB

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Piperine across SCCS product categories, with measured dermal absorption where available.

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Regulatory (2)

JECFA Number

1600

Source: WHO/JECFA

JECFA Evaluation

PIPERINE | 2005 | No safety concern at current levels of intake when used as a flavouring agent | TRS 934-JECFA 65/89 | FAS 56-JECFA 65

Source: WHO/JECFA

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Flavouring and nutrient Fragrance

Regulatory List Membership (2)

IFRA Fragrance Transparency List FDA Substances Added to Food (EAFUS)

Editorial summary

Preliminary editorial summary for Piperine — not a computed safety verdict. See the sourced toxicological data above.

Regulatory Flags

ifra_fragrance fda_food_additive jecfa_safe

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Piperine by CAS number or substance name.

Studies

Lowest NOAEL

1.12 mg/kg bw/day

Highest NOAEL

25 mg/kg bw/day

COSMOS DB

Known Synonyms

Piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]- 1-(5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (E,E)- 1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine EINECS 202-348-0 FEMA No. 2909 Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)- Piperoylpiperidine 1-Piperoylpiperidine, (E,E)- UNII-U71XL721QK (E,E)-1-piperoylpiperidine 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl]piperidine N-[(E,E)-Piperoyl]piperidine

Chemical Function

Fragrance Flavouring and nutrient

Regulatory Lists

active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical and food safety data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound

PIPERINE

ChEMBL ID

CHEMBL43185

Max Phase

Adverse Event Associations

View full pharmaceutical profile →

SOURCE EFSA / FDA GRAS food_additives

Food Safety Data

Same-CAS food additive or FDA GRAS records from the core public database.

Food Name

Piperine (BioPerine)

Food Category

sports_nutrition

View full food safety profile →

Frequently Asked Questions

Is Piperine safe in cosmetics?

Piperine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.

Is Piperine allowed in the EU?

Piperine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Piperine do in cosmetics?

Piperine functions as: Skin conditioning, bioenhancer (increases dermal penetration of co-formulated actives). It is classified as a cosmetic ingredient in our database. CAS number: 94-62-2.

What is the NOAEL for Piperine?

The NOAEL (No Observed Adverse Effect Level) for Piperine is 1.12 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 3 study endpoints are available. Source: COSMOS DB.

Is Piperine used outside cosmetics?

Piperine also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Piperine have different safety status in cosmetics vs industrial chemicals?

Piperine is classified GHS Danger (H301) in the chemicals database but is allowed in EU cosmetics.

Compliance Tools

Check Piperine compliance across multiple jurisdictions:

Ingredient Decoder

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82 Allergen Checker

Check for EU declarable fragrance allergens

Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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