Is Piperine safe in cosmetics?
Piperine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Piperine
Also known as: Piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, 1-(5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (E,E)-, 1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine, EINECS 202-348-0, FEMA No. 2909 (+8 more)
INCI: PIPERINE
Piperine (CAS 94-62-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning, bioenhancer (increases dermal penetration of co-formulated. NOAEL 5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 94-62-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Piperine is classified GHS Danger (H301) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning, bioenhancer (increases dermal penetration of co-formulated actives)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
InChIKey
MXXWOMGUGJBKIW-YPCIICBESA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS for food use (21 CFR); permitted in cosmetics under general provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Piperine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Piperine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1.12 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Piperine across SCCS product categories, with measured dermal absorption where available.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection, bioavailability enhancer", "mechanism_of_action": "Specialized bioactive mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "12", "sample_size": "28", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": …
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1600
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PIPERINE | 2005 | No safety concern at current levels of intake when used as a flavouring agent | TRS 934-JECFA 65/89 | FAS 56-JECFA 65
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Piperine.
Regulatory Flags
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Piperine by CAS number or substance name.
Studies
3
Lowest NOAEL
1.12 mg/kg bw/day
Highest NOAEL
25 mg/kg bw/day
COSMOS_DB
Known Synonyms
Piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-
1-(5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (E,E)-
1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine
EINECS 202-348-0
FEMA No. 2909
Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-
Piperoylpiperidine
1-Piperoylpiperidine, (E,E)-
UNII-U71XL721QK
(E,E)-1-piperoylpiperidine
1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine
1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl]piperidine
N-[(E,E)-Piperoyl]piperidine
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PIPERINE
ChEMBL ID
CHEMBL43185
Max Phase
2
Adverse Event Associations
2
Frequently Asked Questions
Is Piperine allowed in the EU?
Piperine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperine do in cosmetics?
Piperine functions as: Skin conditioning, bioenhancer (increases dermal penetration of co-formulated actives). It is classified as a cosmetic ingredient in our database. CAS number: 94-62-2.
What is the NOAEL for Piperine?
The NOAEL (No Observed Adverse Effect Level) for Piperine is 1.12 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is Piperine used outside cosmetics?
Piperine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Piperine have different safety status in cosmetics vs industrial chemicals?
Piperine is classified GHS Danger (H301) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Piperine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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