Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Piperine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 89.1 mg/kg bw/day | oral | mouse | Neurotoxicity | COSMOS_DB |
| NOAEL | 350 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 5 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
| NOAEL | 75 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1.12 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
Expert Verdict
H302 Harmful if swallowed. Bioenhancer activity increases penetration of all co-formulated ingredients and must be accounted for in CPSR MoS calculation of every other ingredient in the formula. Methylenedioxy group is a CYP inhibitor.
Regulatory Flags
Frequently Asked Questions
Is Piperine safe in cosmetics?
H302 Harmful if swallowed. Bioenhancer activity increases penetration of all co-formulated ingredients and must be accounted for in CPSR MoS calculation of every other ingredient in the formula. Methylenedioxy group is a CYP inhibitor. The EU classifies Piperine as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Piperine allowed in the EU?
Piperine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperine do in cosmetics?
Piperine functions as: Skin conditioning, bioenhancer (increases dermal penetration of co-formulated actives). It is classified as a cosmetic ingredient in our database. CAS number: 94-62-2.
What is the Margin of Safety for Piperine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Piperine?
The NOAEL (No Observed Adverse Effect Level) for Piperine is 89.1 mg/kg bw/day based on a Neurotoxicity study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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