NOAEL Studies
Cosmetic Ingredient
Piperonyl Butoxide NOAEL Studies
INCI: PIPERONYL BUTOXIDE
CAS: 51-03-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | LOAEL | 10 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | REACH; study report |
| COSMOS_DB | NOAEL | 100 | ppm | dog | oral | 1 year | Subchronic | REACH; study report |
| COSMOS_DB | NOAEL | 100 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | REACH; study report |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1987 | IARC Monographs | {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"30, Sup 7"} |
NTP_ICE_acute_dermal 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=392; Record_ID=acute_dermal_309; Data_Type=In Vivo; Formulation_ID=MIX302; Formulation_Name=MCSI Hydroprene Cockroack Killer Fogger; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=400; Record_ID=acute_dermal_380; Data_Type=In Vivo; Formulation_ID=MIX374; Formulation_Name=Pyrocide Falcon 7452; Percent_Active_Ingredient=2.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=393; Record_ID=acute_dermal_380; Data_Type=In Vivo; Formulation_ID=MIX374; Formulation_Name=Pyrocide Falcon 7452; Percent_Active_Ingredient=2.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=397; Record_ID=acute_dermal_377; Data_Type=In Vivo; Formulation_ID=MIX371; Formulation_Name=Pyranha 1-10 PPC Concentrate; Percent_Active_Ingredient=20.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=412; Record_ID=acute_dermal_380; Data_Type=In Vivo; Formulation_ID=MIX374; Formulation_Name=Pyrocide Falcon 7452; Percent_Active_Ingredient=2.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
NTP_ICE_acute_inhalation 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | EPA Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=800; Record_ID=acute_inhalation_317; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX371; Formulation_Name=Pyranha 1-10 PPC Concentrate; Percent_Active_Ingredient=20.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | EPA Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=802; Record_ID=acute_inhalation_300; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX378; Formulation_Name=Raid Ant & Roach Killer with Germ Kill CIK; Percent_Active_Ingredient=0.2; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | LC50 | >2.99 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=798; Record_ID=acute_inhalation_209; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX302; Formulation_Name=MCSI Hydroprene Cockroack Killer Fogger; Percent_Active_Ingredient=0.1; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.99; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | LC50 | >2.06 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=799; Record_ID=acute_inhalation_202; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX253; Formulation_Name=Gordon's Horse & Pony Spray; Percent_Active_Ingredient=0.5; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.06; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | LC50 | >5.9 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=814; Record_ID=acute_inhalation_1776; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.9; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10134/7/3/3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | LC50 | >2.21 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=815; Record_ID=acute_inhalation_294; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX374; Formulation_Name=Pyrocide Falcon 7452; Percent_Active_Ingredient=2.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.21; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | LC50 | >2.05 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=817; Record_ID=acute_inhalation_317; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX371; Formulation_Name=Pyranha 1-10 PPC Concentrate; Percent_Active_Ingredient=20.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.05; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | LC50 | >2.09 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=819; Record_ID=acute_inhalation_229; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX326; Formulation_Name=MGK Fogging Concentrate 2922; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.09; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | LC50 | >5.2 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=820; Record_ID=acute_inhalation_1827; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.2; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/3/3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_acute_inhalation | LC50 | >2.07 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=825; Record_ID=acute_inhalation_361; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX467; Formulation_Name=TC-320; Percent_Active_Ingredient=4.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.07; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
NTP_ICE_acute_oral 32 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12897; row=2135; data_type=In Vivo; mixture=Mixture; formulation_id=MIX374; formulation_name=Pyrocide Falcon 7452; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=2.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12879; row=2136; data_type=In Vivo; mixture=Mixture; formulation_id=MIX378; formulation_name=Raid Ant & Roach Killer with Germ Kill CIK; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.2; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13084; row=2146; data_type=In Vivo; mixture=Mixture; formulation_id=MIX467; formulation_name=TC-320; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=4.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =3 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12889; row=2160; data_type=In Vivo; mixture=Mixture; formulation_id=MIX371; formulation_name=Pyranha 1-10 PPC Concentrate; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=20.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12749; row=2176; data_type=In Vivo; mixture=Mixture; formulation_id=MIX326; formulation_name=MGK Fogging Concentrate 2922; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=5.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12752; row=2177; data_type=In Vivo; mixture=Mixture; formulation_id=MIX332; formulation_name=MGK Formula 2980; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=27.5; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =3 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13168; row=2178; data_type=In Vivo; mixture=Mixture; formulation_id=MIX671; formulation_name=Bug Stomper II; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=15.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =3 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12623; row=2179; data_type=In Vivo; mixture=Mixture; formulation_id=MIX253; formulation_name=Gordon's Horse & Pony Spray; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.5; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12710; row=2182; data_type=In Vivo; mixture=Mixture; formulation_id=MIX302; formulation_name=MCSI Hydroprene Cockroack Killer Fogger; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.1; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12882; row=2139; data_type=In Vivo; mixture=Mixture; formulation_id=MIX378; formulation_name=Raid Ant & Roach Killer with Germ Kill CIK; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.2; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12897; row=2141; data_type=In Vivo; mixture=Mixture; formulation_id=MIX374; formulation_name=Pyrocide Falcon 7452; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=2.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13084; row=2143; data_type=In Vivo; mixture=Mixture; formulation_id=MIX467; formulation_name=TC-320; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=4.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12711; row=2144; data_type=In Vivo; mixture=Mixture; formulation_id=MIX302; formulation_name=MCSI Hydroprene Cockroack Killer Fogger; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.1; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =4 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13168; row=2145; data_type=In Vivo; mixture=Mixture; formulation_id=MIX671; formulation_name=Bug Stomper II; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=15.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12623; row=2147; data_type=In Vivo; mixture=Mixture; formulation_id=MIX253; formulation_name=Gordon's Horse & Pony Spray; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.5; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12752; row=2152; data_type=In Vivo; mixture=Mixture; formulation_id=MIX332; formulation_name=MGK Formula 2980; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=27.5; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12749; row=2153; data_type=In Vivo; mixture=Mixture; formulation_id=MIX326; formulation_name=MGK Fogging Concentrate 2922; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=5.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =4 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12889; row=2154; data_type=In Vivo; mixture=Mixture; formulation_id=MIX371; formulation_name=Pyranha 1-10 PPC Concentrate; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=20.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13084; row=2155; data_type=In Vivo; mixture=Mixture; formulation_id=MIX467; formulation_name=TC-320; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=4.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12897; row=2156; data_type=In Vivo; mixture=Mixture; formulation_id=MIX374; formulation_name=Pyrocide Falcon 7452; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=2.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1750 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12889; row=2157; data_type=In Vivo; mixture=Mixture; formulation_id=MIX371; formulation_name=Pyranha 1-10 PPC Concentrate; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=20.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12878; row=2158; data_type=In Vivo; mixture=Mixture; formulation_id=MIX378; formulation_name=Raid Ant & Roach Killer with Germ Kill CIK; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.2; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1750 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12752; row=2162; data_type=In Vivo; mixture=Mixture; formulation_id=MIX332; formulation_name=MGK Formula 2980; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=27.5; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12749; row=2163; data_type=In Vivo; mixture=Mixture; formulation_id=MIX326; formulation_name=MGK Fogging Concentrate 2922; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=5.0; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12712; row=2164; data_type=In Vivo; mixture=Mixture; formulation_id=MIX302; formulation_name=MCSI Hydroprene Cockroack Killer Fogger; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.1; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =11500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_6904; row=2165; data_type=In Vivo; mixture=Chemical; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; dtxsid=DTXSID1021166; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12621; row=2168; data_type=In Vivo; mixture=Mixture; formulation_id=MIX253; formulation_name=Gordon's Horse & Pony Spray; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; percent_active_ingredient=0.5; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =7220 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_6903; row=2170; data_type=In Vivo; mixture=Chemical; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; dtxsid=DTXSID1021166; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =6150 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_6902; row=2172; data_type=In Vivo; mixture=Chemical; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; dtxsid=DTXSID1021166; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =5630 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_6901; row=2173; data_type=In Vivo; mixture=Chemical; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; dtxsid=DTXSID1021166; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4570 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_6900; row=2174; data_type=In Vivo; mixture=Chemical; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; dtxsid=DTXSID1021166; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_6899; row=2175; data_type=In Vivo; mixture=Chemical; chemical_name=Piperonyl butoxide; preferred_name=Piperonyl butoxide; dtxsid=DTXSID1021166; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021166; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 76.01 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=457; Record_ID=adme_parameters_212; Data_Type=Measured; DTXSID=DTXSID1021166; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=76.01; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_adme_parameters | Fu | 0 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=456; Record_ID=adme_parameters_212; Data_Type=Measured; DTXSID=DTXSID1021166; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
NTP_ICE_cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=1535; Record_ID=cancer_1840; Data_Type=WOE; Formulation_Name=Piperonyl butoxide; Mixture=Chemical; DTXSID=DTXSID1021166; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/48; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_cancer | Top dose | 10000 | ppm | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1528; Record_ID=cancer_1842; Data_Type=In Vivo; Formulation_Name=Piperonyl butoxide; Mixture=Chemical; DTXSID=DTXSID1021166; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=10000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Reference=TR-120; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr120/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_cancer | Top dose | 2804 | ppm | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1533; Record_ID=cancer_1838; Data_Type=In Vivo; Formulation_Name=Piperonyl butoxide; Mixture=Chemical; DTXSID=DTXSID1021166; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2804; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Reference=TR-120; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr120/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
NTP_ICE_endocrine 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 23.6551584015404 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13450; RecordID=ERPathway2016_473; DatasetName=ERPathway2016; DTXSID=DTXSID1021166; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=23.6551584015404; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_endocrine | ACC | 17.9316780462754 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13451; RecordID=ERPathway2016_473; DatasetName=ERPathway2016; DTXSID=DTXSID1021166; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=17.9316780462754; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13446; RecordID=ARPathway2016_1251; DatasetName=ARPathway2016; DTXSID=DTXSID1021166; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_endocrine | Model Score | 0.00231 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=13452; RecordID=ERPathway2016_473; DatasetName=ERPathway2016; DTXSID=DTXSID1021166; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00231; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_endocrine | NOEL | 1000 | mg/kg bw/day | Rat | Oral | Treatment_Duration=10 days; Age_at_First_Dose=PND 58; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=16 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=8 | In Vivo; Hershberger-Agonist | sheet=Data_invivo; excel_row=1236; Record_ID=endocrine_invivo_536; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1021166; Assay=Hershberger-Agonist; Endpoint=NOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Reference_Hormone=Testosterone propionate; Reference_Hormone_Dose=0.4; Reference_Hormone_Dose_Units=mg/kg/day; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 453; Reference=US EPA 2015; Not available; https://www.regulations.gov/document/EPA-HQ-OPP-2010-0498-0019|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
NTP_ICE_eye_irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=426; Record_ID=eye_irritation_1053; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID934; Formulation_Name=TC-320; Percent_Active_Ingredient=4.0; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_eye_irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=429; Record_ID=eye_irritation_821; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID660; Formulation_Name=MGK Formula 2980; Percent_Active_Ingredient=27.5; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
NTP_ICE_skin_irritation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=311; Record_ID=skin_irritation_invivo_299; Data_Type=In Vivo; Formulation_ID=MIX332; Formulation_Name=MGK Formula 2980; Percent_Active_Ingredient=27.5; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_skin_irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=313; Record_ID=skin_irritation_invivo_190; Data_Type=In Vivo; Formulation_ID=MIX371; Formulation_Name=Pyranha 1-10 PPC Concentrate; Percent_Active_Ingredient=20; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
| NTP_ICE_skin_irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=318; Record_ID=skin_irritation_invivo_1056; Data_Type=In Vivo; Formulation_ID=MIX378; Formulation_Name=Raid Ant & Roach Killer with Germ Kill CIK; Percent_Active_Ingredient=0.2; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male/Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
NTP_ICE_skin_sensitization 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Guinea pig | Dermal | - | In Vivo; SkinSensitization6pack; Guinea Pig Maximization/Buehler | sheet=Data_invivo; excel_row=997; Record_ID=skin_sensitization_invivo_208; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX253; Formulation_Name=Gordon's Horse & Pony Spray; Percent_Active_Ingredient=0.5; Mixture=Mixture; DTXSID=DTXSID1021166; Assay=Guinea Pig Maximization/Buehler; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Guinea pig; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021166 |
ToxRefDB_ToxRefDB_v3_pod.csv 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =100 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=3748; toxval_study_source_id=studyid3748_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-defecation|in life observation-body weight-body weight gain; dose_level=2; study_year=1986; study_citation=Leng, J. (1986) Teratology Study in Rabbits [Using Piperonyl Butoxide]: Study No. 542-002. Unpublished study prepared by International Research and Development Corp. 61 p.; dsstox_substance_id=DTXSID1021166; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =500 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=3749; toxval_study_source_id=studyid3749_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-clinical signs-wetness|in life observation-clinical signs-hemorrhagic perineal discharge|in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|in life observation-clinical signs-urine staining - perineum; dose_level=2; study_year=1991; study_citation=Chun, J.; Neeper-Bradley, T. (1991) Developmental Toxicity Evaluation of Piperonyl Butoxide Administered by Gavage to CD (Sprague-Dawley) Rats: Lab Project Number: 54-586. Unpublished study prepared by Bushy Run Research Center. 283 p.; dsstox_substance_id=DTXSID1021166; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >1000 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=3749; toxval_study_source_id=studyid3749_Fetal_Fetal_MF_NA; dose_level=3; study_year=1991; study_citation=Chun, J.; Neeper-Bradley, T. (1991) Developmental Toxicity Evaluation of Piperonyl Butoxide Administered by Gavage to CD (Sprague-Dawley) Rats: Lab Project Number: 54-586. Unpublished study prepared by Bushy Run Research Center. 283 p.; dsstox_substance_id=DTXSID1021166; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >469 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 42 days (premating) to 2 generation | MGR | study_id=3750; toxval_study_source_id=studyid3750_Adult_F0_F_NA; dose_level=3; study_year=1986; study_citation=Robinson, K.; Pinsonneault, L.; Procter, B. (1986) A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat. Research Report: Project No. 81689. Unpublished study prepared by Bio-Research Laboratories.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =528 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 42 days (premating) to 2 generation | MGR | study_id=3750; toxval_study_source_id=studyid3750_Juvenile_F2_F_systemic; toxval_effect_list=in life observation-body weight-offspring (pup) weight gain; dose_level=3; study_year=1986; study_citation=Robinson, K.; Pinsonneault, L.; Procter, B. (1986) A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat. Research Report: Project No. 81689. Unpublished study prepared by Bio-Research Laboratories.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =16.3 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 month to 12 month | CHR | study_id=3751; toxval_study_source_id=studyid3751_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-liver-absolute|in life observation-body weight-body weight gain|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|pathology microscopic-liver-hypertrophy; dose_level=2; study_year=1993; study_citation=Goldenthal, E. (1993) Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004. Unpublished study prepared by International Research and Development Corp. 326 p.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =15.5 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 month to 12 month | CHR | study_id=3751; toxval_study_source_id=studyid3751_Adult_F0_M_systemic; toxval_effect_list=in life observation-food consumption-food consumption|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|in life observation-body weight-body weight gain|organ weight-liver-relative to body weight|organ weight-liver-absolute|pathology microscopic-liver-hypertrophy; dose_level=2; study_year=1993; study_citation=Goldenthal, E. (1993) Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004. Unpublished study prepared by International Research and Development Corp. 326 p.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =30 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 24 month | CHR | study_id=3755; toxval_study_source_id=studyid3755_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to brain weight|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|pathology gross-liver-irregular surface|pathology microscopic-liver-mixed cell focus|organ weight-liver-relative to body weight|pathology gross-liver-discolored|pathology microscopic-thyroid gland-hyperplasia|pathology gross-liver-accentuated lobular pattern|clinical chemistry-cholesterol-cholesterol|pathology gross-liver-mass|clinical chemistry-protein-protein|pathology microscopic-liver-hypertrophy|pathology microscopic-thyroid gland-pigmentation|in life observation-body weight-body weight gain; dose_level=2; study_year=1987; study_citation=Graham, C.; Bujold, H. (1987) 24-Month Dietary Toxicity and Carcinogenicity Study of Piperonyl Butoxide in the Albino Rat: Lab. Proj. ID 81690. Unpublished study prepared by Bio-Research Laboratories Ltd. 2576 p.; dsstox_substance_id=DTXSID1021166; admin_method=[Not Specified]; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 107 week | CHR | study_id=7447; toxval_study_source_id=studyid7447_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology gross-full gross necropsy-lymphoma nos; dose_level=1; study_year=1979; study_citation=BIOASSAY OF PIPERONYL BUTOXIDE FOR POSSIBLE CARCINOGENICITY CAS No. 51-03-6. Study No: NCI-CG-TR-120, DHEW Publication No. (NIH) 79-1375. (Rat portion); dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =155.4 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 112 week | CHR | study_id=7448; toxval_study_source_id=studyid7448_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-clinical signs-alopecia; dose_level=1; study_year=1979; study_citation=BIOASSAY OF PIPERONYL BUTOXIDE FOR POSSIBLE CARCINOGENICITY CAS No. 51-03-6. Study No: NCI-CG-TR-120, DHEW Publication No. (NIH) 79-1375. (Mouse portion); dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | >200 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=3748; toxval_study_source_id=studyid3748_Adult_F0_F_NA; dose_level=3; study_year=1986; study_citation=Leng, J. (1986) Teratology Study in Rabbits [Using Piperonyl Butoxide]: Study No. 542-002. Unpublished study prepared by International Research and Development Corp. 61 p.; dsstox_substance_id=DTXSID1021166; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =100 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 24 month | CHR | study_id=3755; toxval_study_source_id=studyid3755_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to brain weight|pathology microscopic-liver-mixed cell focus|organ weight-liver-relative to body weight|clinical chemistry-cholesterol-cholesterol; dose_level=3; study_year=1987; study_citation=Graham, C.; Bujold, H. (1987) 24-Month Dietary Toxicity and Carcinogenicity Study of Piperonyl Butoxide in the Albino Rat: Lab. Proj. ID 81690. Unpublished study prepared by Bio-Research Laboratories Ltd. 2576 p.; dsstox_substance_id=DTXSID1021166; admin_method=[Not Specified]; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =500 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 107 week | CHR | study_id=7447; toxval_study_source_id=studyid7447_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1979; study_citation=BIOASSAY OF PIPERONYL BUTOXIDE FOR POSSIBLE CARCINOGENICITY CAS No. 51-03-6. Study No: NCI-CG-TR-120, DHEW Publication No. (NIH) 79-1375. (Rat portion); dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =50 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=3748; toxval_study_source_id=studyid3748_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-clinical signs-defecation; dose_level=1; study_year=1986; study_citation=Leng, J. (1986) Teratology Study in Rabbits [Using Piperonyl Butoxide]: Study No. 542-002. Unpublished study prepared by International Research and Development Corp. 61 p.; dsstox_substance_id=DTXSID1021166; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =200 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=3749; toxval_study_source_id=studyid3749_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-clinical signs-hemorrhagic perineal discharge|in life observation-clinical signs-wetness|in life observation-clinical signs-urine staining - perineum|in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|in life observation-body weight-body weight gain; dose_level=1; study_year=1991; study_citation=Chun, J.; Neeper-Bradley, T. (1991) Developmental Toxicity Evaluation of Piperonyl Butoxide Administered by Gavage to CD (Sprague-Dawley) Rats: Lab Project Number: 54-586. Unpublished study prepared by Bushy Run Research Center. 283 p.; dsstox_substance_id=DTXSID1021166; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =102 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 42 days (premating) to 2 generation | MGR | study_id=3750; toxval_study_source_id=studyid3750_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=1986; study_citation=Robinson, K.; Pinsonneault, L.; Procter, B. (1986) A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat. Research Report: Project No. 81689. Unpublished study prepared by Bio-Research Laboratories.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =89 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 42 days (premating) to 2 generation | MGR | study_id=3750; toxval_study_source_id=studyid3750_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=1986; study_citation=Robinson, K.; Pinsonneault, L.; Procter, B. (1986) A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat. Research Report: Project No. 81689. Unpublished study prepared by Bio-Research Laboratories.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =2.7 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 month to 12 month | CHR | study_id=3751; toxval_study_source_id=studyid3751_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|organ weight-liver-relative to body weight|pathology microscopic-liver-hypertrophy|in life observation-body weight-body weight gain; dose_level=1; study_year=1993; study_citation=Goldenthal, E. (1993) Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004. Unpublished study prepared by International Research and Development Corp. 326 p.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =2.9 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 month to 12 month | CHR | study_id=3751; toxval_study_source_id=studyid3751_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology microscopic-liver-hypertrophy|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|organ weight-liver-absolute|organ weight-liver-relative to body weight|in life observation-food consumption-food consumption; dose_level=1; study_year=1993; study_citation=Goldenthal, E. (1993) Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004. Unpublished study prepared by International Research and Development Corp. 326 p.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =30 | mg/kg bw/day | mouse (cd1; CD) | oral | 0 day to 78 week | CHR | study_id=3753; toxval_study_source_id=studyid3753_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|pathology microscopic-liver-adenoma; dose_level=1; study_year=1993; study_citation=Hermansky, S.; Wagner, C. (1993) Chronic Dietary Oncogenicity Study with Piperonyl Butoxide in CD-1 Mice: Lab Project Number: 91N0134. Unpublished study prepared by Bushy Run Research Center. 1550 p.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | mouse (cd1; CD) | oral | 0 day to 78 week | CHR | study_id=3753; toxval_study_source_id=studyid3753_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-carcinoma|organ weight-liver-relative to body weight|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-liver-hemorrhage|pathology microscopic-liver-hypertrophy|pathology microscopic-liver-adenoma; dose_level=0; study_year=1993; study_citation=Hermansky, S.; Wagner, C. (1993) Chronic Dietary Oncogenicity Study with Piperonyl Butoxide in CD-1 Mice: Lab Project Number: 91N0134. Unpublished study prepared by Bushy Run Research Center. 1550 p.; dsstox_substance_id=DTXSID1021166; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =15 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 24 month | CHR | study_id=3755; toxval_study_source_id=studyid3755_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-mixed cell focus|organ weight-liver-relative to body weight|pathology gross-liver-discolored|pathology microscopic-thyroid gland-hyperplasia|pathology gross-liver-accentuated lobular pattern|clinical chemistry-cholesterol-cholesterol|in life observation-body weight-body weight gain|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|pathology microscopic-thyroid gland-pigmentation|pathology gross-liver-irregular surface|clinical chemistry-protein-protein|organ weight-liver-absolute|pathology microscopic-liver-hypertrophy|pathology gross-liver-mass|organ weight-liver-relative to brain weight; dose_level=1; study_year=1987; study_citation=Graham, C.; Bujold, H. (1987) 24-Month Dietary Toxicity and Carcinogenicity Study of Piperonyl Butoxide in the Albino Rat: Lab. Proj. ID 81690. Unpublished study prepared by Bio-Research Laboratories Ltd. 2576 p.; dsstox_substance_id=DTXSID1021166; admin_method=[Not Specified]; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_AU_DWG 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_AU_DWG | NOEL | =16 | mg/kg bw/day | Dog | oral | chronic; 1 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c82db5e4b02565fc7d237c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nhmrc.gov.au; SUBSOURCE_URL=https://www.nhmrc.gov.au/sites/default/files/documents/attachments/publications/Australian_Drinking_Water_Guidelines_ADWG_V3-8_Sep2022.pdf; TOXICOLOGICAL_EFFECT=increased liver weight and associated hepatocellular hypertrophy, increased serum ALP activity, and increased thyroid weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=AU DWG:15951720:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a810cf3ff9521644f2973f4be146317 |
ToxValDB_ECHA_IUCLID 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | >=7.8 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e4a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817342_15818575_15818576_15820462:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e2544f253a4dc4590bc66f6d2d1df065 |
| ToxValDB_ECHA_IUCLID | LOAEL | >=18.5 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818247_15818248_15819412_15819413_15820463:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48271faee4ea958139bf9453dcde286e |
| ToxValDB_ECHA_IUCLID | LOAEL | =390 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819004_15820464:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_55ba104cf2d7b6480c81092570fe8645 |
| ToxValDB_ECHA_IUCLID | LOAEL | >=512 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/3?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829072_15829073:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47034b798c91b2b185fc289e3ad88259 |
| ToxValDB_ECHA_IUCLID | LOAEL | =74 | mg/kg bw/day | Dog | oral | subchronic; 8 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d225740; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830145_15849515:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_005c1fdc188608369364b95d423d43e6 |
| ToxValDB_ECHA_IUCLID | LOAEL | =300 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d225763; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831081_15847306:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2455a6cf5d24cbb6a4fc6644d8ac78bf |
| ToxValDB_ECHA_IUCLID | LOAEL | =250 | mg/kg bw/day | Rat | oral | subchronic; 31 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d225792; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839873_15847443:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_57fdc4ada61422a085cc18caf72e7c7e |
| ToxValDB_ECHA_IUCLID | LOAEL | =40 | mg/kg bw/day | Dog | oral | chronic; 1 years | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d2257b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845165_15847499_15848749:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a6f4d00286c88e069196547966c2843 |
| ToxValDB_ECHA_IUCLID | LOAEL | =576 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d22576c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID:15848813:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dc1ccf6158b04d2c9c8ae7ccc067c9a8 |
| ToxValDB_ECHA_IUCLID | LOAEL | =5000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c904e4b0a7c65d21b161; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/9/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855315_15855813_15856155_15856565:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c2e39e4d61581ccaa769e779cab3f8a |
| ToxValDB_ECHA_IUCLID | LOAEL | =1000 | ppm | Mouse | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c904e4b0a7c65d21b150; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/9/2?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID:15859065:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_599da9662eab1a84416c39434bd609d4 |
| ToxValDB_ECHA_IUCLID | NOAEC | =155 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/3?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID:15827220:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1cf98c258d0049f5700b951482520448 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=300 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818247_15818248_15819412_15819413_15820463:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b2ccac0a84dece60d0b833a70fce0ea1 |
| ToxValDB_ECHA_IUCLID | NOAEL | =30 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817342_15818575_15818576_15820462:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0dca5b6fc25f8cfbb890105cefc17633 |
| ToxValDB_ECHA_IUCLID | NOAEL | =500 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817342_15818575_15818576_15820462:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e07b82abd2f174ab81960dfac790e015 |
| ToxValDB_ECHA_IUCLID | NOAEL | =780 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819004_15820464:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_53be27910a679ba3d9720703bb961074 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=2.34 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e4a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817342_15818575_15818576_15820462:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_54a14703f00b95b647d823adb11919a9 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=5.55 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216e50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/8?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818247_15818248_15819412_15819413_15820463:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fd4cfe6d70b5b0446ce99d3666012e7b |
| ToxValDB_ECHA_IUCLID | NOAEL | >1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1dce4b0a7c65d2308d9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/9/3?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821824_15824873:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b865acf748ab503fa944702687c9b7b |
| ToxValDB_ECHA_IUCLID | NOAEL | >200 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1dce4b0a7c65d2308e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/9/3?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID:15823788:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b52a10bd15b3fcc03e140d6573312e94 |
| ToxValDB_ECHA_IUCLID | NOAEL | >4000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1dce4b0a7c65d2308c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/9/3?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821824_15824873:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2bf093f662e6c68db39e879f811ae184 |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Rabbit | dermal | short-term; 3 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f2ae4b096bca877c832; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/4?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826764_15826765:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a34c86e5a8660696a715957df81c4bc5 |
| ToxValDB_ECHA_IUCLID | NOAEL | =155 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/3?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829072_15829073:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_98166c2f7b868dad79c7f4bee973bf3b |
| ToxValDB_ECHA_IUCLID | NOAEL | =125 | mg/kg bw/day | Rat | oral | subchronic; 31 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d225792; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839873_15847443:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b283f37eadb5f270db57fc6a0efc8fd8 |
| ToxValDB_ECHA_IUCLID | NOAEL | =12 | mg/kg bw/day | Dog | oral | chronic; 1 years | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d2257b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845165_15847499_15848749:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_42769e49a70905f579363ad899df938b |
| ToxValDB_ECHA_IUCLID | NOAEL | =37 | mg/kg bw/day | Dog | oral | subchronic; 8 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d225740; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; YEAR=0; ORIGINAL_YEAR=0; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830145_15849515:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_18122e0c6cf3ef12779fa6e48cd64618 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1411.2 | mg/kg bw/day | Rat | oral | subchronic; 7 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb43e4b0a7c65d225783; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/6/2?documentUUID=5b2bba81-7119-40e5-8439-05985415ddf5; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID:15849517:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9e1626dc428f89fe2f03bf4cae0c3959 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c904e4b0a7c65d21b161; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6020/7/9/2?documentUUID=cc9621ee-2e5b-43d7-9af6-43eb41d23d65; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855315_15855813_15856155_15856565:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ed7c75af2d0e384c486830e48ecf1f5 |
ToxValDB_ECOTOX 57 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =0.2 | % | Rat | oral | short-term; 14 days | short-term | LONG_REF=Arch. Toxicol.72(11): 744-750 Okamiya,H., K. Mitsumori, H. Onodera, S. Ito, T. Imazawa, K. Yasuhara, and M. Takahashi Mechanistic Study on Liver Tumor Promoting Effects of Piperonyl Butoxide in Rats 1998; TITLE=Mechanistic Study on Liver Tumor Promoting Effects of Piperonyl Butoxide in Rats; AUTHOR=Okamiya,H., K. Mitsumori, H. Onodera, S. Ito, T. Imazawa, K. Yasuhara, and M. Takahashi; DOI=10.1007/s002040050569; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74865; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594080_15594081_15600785_15610538_15610569:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7a2bc6f336f105955f6b2790c5f772b4 |
| ToxValDB_ECOTOX | LOEL | =1.2 | % | Mouse | oral | chronic; 365 days | chronic | LONG_REF=Toxicol. Pathol.26(2): 301-303 Takahashi,O., S. Oishi, M. Yoneyama, T. Tanaka, and T. Fujitani Mouse Liver Nodules Induced by Piperonyl Butoxide, a Mixed-Function Oxidase Inducer 1998; TITLE=Mouse Liver Nodules Induced by Piperonyl Butoxide, a Mixed-Function Oxidase Inducer; AUTHOR=Takahashi,O., S. Oishi, M. Yoneyama, T. Tanaka, and T. Fujitani; DOI=10.1177/019262339802600219; QUALITY=Control type: Control data is presented but without accompanying methodology; EXTERNAL_SOURCE_ID=75518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Injury: Injury, general; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594252_15594253_15598843:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=36fdc2e325b5ad0a535a6bb2ecfdfd59 |
| ToxValDB_ECOTOX | LOEL | =2.4 | % | Rat | oral | chronic; 91 days | chronic | LONG_REF=Toxicology72(3): 291-298 Fujitani,T., H. Ando, K. Fujitani, T. Ikeda, A. Kojima, Y. Kubo, A. Ogata, S. Oishi, H. Takahashi, O. Takahashi, and M. Sub-Acute Toxicity of Piperonyl Butoxide in F344 Rats 1992; TITLE=Sub-Acute Toxicity of Piperonyl Butoxide in F344 Rats; AUTHOR=Fujitani,T., H. Ando, K. Fujitani, T. Ikeda, A. Kojima, Y. Kubo, A. Ogata, S. Oishi, H. Takahashi, O. Takahashi, and M.; DOI=10.1016/0300-483x(92)90180-m; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119340; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Enzyme(s): gamma-glutamyl transpeptidase|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594334_15594335_15594336_15594337_15605363:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e7536bd1d0082e3354a62673b3edd98 |
| ToxValDB_ECOTOX | LOEL | =2 | % | Rat | oral | subchronic; 49 days | subchronic | LONG_REF=J. Toxicol. Sci.33(2): 197-207 Yasuno,H., J. Nishimura, Y. Dewa, M. Muguruma, M. Takabatake, Y. Murata, M. Shibutani, and K. Mitsumori Modifying Effect of Siraitia grosvenori Extract on Piperonyl Butoxide-Promoted Hepatocarcinogenesis in Rats 2008; TITLE=Modifying Effect of Siraitia grosvenori Extract on Piperonyl Butoxide-Promoted Hepatocarcinogenesis in Rats; AUTHOR=Yasuno,H., J. Nishimura, Y. Dewa, M. Muguruma, M. Takabatake, Y. Murata, M. Shibutani, and K. Mitsumori; DOI=10.2131/jts.33.197; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119620; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Biochemistry: Thiobarbituric acid reactive substances|Enzyme(s): Glutathione S-transferase|Genetics: Glutathione reductase mRNA|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|other; STUDY_GROUP=ECOTOX:15594520:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ea6f3a4cee366939bd39a3fd2b75387d |
| ToxValDB_ECOTOX | LOEL | =5000 | ppm | Rat | oral | short-term; 15 days | short-term | LONG_REF=Trace Subst. Environ. Health:363-371 Wagstaff,D.J. Detoxification of Lead Acetate and Other Trace Substances 1971; TITLE=Detoxification of Lead Acetate and Other Trace Substances; AUTHOR=Wagstaff,D.J.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=118728; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P450 dependent O-demethylase|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594933_15599581:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4d0e0961137a43fb81937c84a7690ce5 |
| ToxValDB_ECOTOX | LOEL | =4 | mmol/kg | Mouse | oral | short-term; 2 days | short-term | LONG_REF=Toxicology94(1-3): 57-67 Mizutani,T., Y. Nakahori, and K.I. Yamamoto p-Dichlorobenzene-Induced Hepatotoxicity in Mice Depleted of Glutathione by Treatment with Buthionine Sulfoximine 1994; TITLE=p-Dichlorobenzene-Induced Hepatotoxicity in Mice Depleted of Glutathione by Treatment with Buthionine Sulfoximine; AUTHOR=Mizutani,T., Y. Nakahori, and K.I. Yamamoto; DOI=10.1016/0300-483x(94)90028-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75110; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595521:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=982563b36bff9901d38883d80000af35 |
| ToxValDB_ECOTOX | LOEL | =2.5 | % diet | Rat | oral | short-term; 14 days | short-term | LONG_REF=Arch. Toxicol.70(12): 809-814 Mitsumori,K., K. Takegawa, T. Shimo, H. Onodera, K. Yasuhara, and M. Takahashi Morphometric and Immunohistochemical Studies on Atrophic Changes in Lympho-Hematopoietic Organs of Rats Treated with Piperonyl Butoxide or Subjected to Dietary Restriction 1996; TITLE=Morphometric and Immunohistochemical Studies on Atrophic Changes in Lympho-Hematopoietic Organs of Rats Treated with Piperonyl Butoxide or Subjected to Dietary Restriction; AUTHOR=Mitsumori,K., K. Takegawa, T. Shimo, H. Onodera, K. Yasuhara, and M. Takahashi; DOI=10.1007/s002040050343; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75786; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Cell(s): Thrombocytes|Feeding behavior: Food consumption|Genetics: PCNA Index|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595734_15604771:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=739c92cc1c870c274c5f4d4645f86e95 |
| ToxValDB_ECOTOX | LOEL | =100 | mg/kg bw/day | Mouse | oral | short-term; 5 days | short-term | LONG_REF=J. Immunotoxicol.11(4): 359-366 Nishino,R., T. Fukuyama, T. Kosaka, K. Hayashi, Y. Watanabe, Y. Kurosawa, H. Ueda, and T. Harada Effects of Short-Term Oral Combined Exposure to Environmental Immunotoxic Chemicals in Mice 2014; TITLE=Effects of Short-Term Oral Combined Exposure to Environmental Immunotoxic Chemicals in Mice; AUTHOR=Nishino,R., T. Fukuyama, T. Kosaka, K. Hayashi, Y. Watanabe, Y. Kurosawa, H. Ueda, and T. Harada; DOI=10.3109/1547691X.2013.851747; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=170300; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=Cell(s): B-cell|Immunological: Plaque forming cell response|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595838:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a80ff99d6de53844068dc96d6e2ab678 |
| ToxValDB_ECOTOX | LOEL | =0.15 | % | Mouse | oral | chronic (developmental) | reproduction developmental | LONG_REF=Toxicol. Lett.60(1): 83-90 Tanaka,T. Effects of Piperonyl Butoxide on F1 Generation Mice 1992; TITLE=Effects of Piperonyl Butoxide on F1 Generation Mice; AUTHOR=Tanaka,T.; DOI=10.1016/0378-4274(92)90050-t; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74888; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596353_15596727_15600570_15600571_15603002_15603003:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5dc07296305fc43ecfef9c3f1749c6b6 |
| ToxValDB_ECOTOX | LOEL | =0.1 | % | Mouse | oral | chronic; 136 days | chronic | LONG_REF=Food Chem. Toxicol.30(12): 1015-1019 Tanaka,T., O. Takahashi, and S. Oishi Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice 1992; TITLE=Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice; AUTHOR=Tanaka,T., O. Takahashi, and S. Oishi; DOI=10.1016/0278-6915(92)90112-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Behavior: Righting response; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15596509:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4921d66e5b25f3bd0bf6464f1587b6e2 |
| ToxValDB_ECOTOX | LOEL | =0.5 | % diet | Rat | oral | chronic; 770 days | chronic | LONG_REF=Food Chem. Toxicol.23(7): 675-682 Maekawa,A., H. Onodera, K. Furuta, H. Tanigawa, T. Ogiu, and Y. Hayashi Lack of Evidence of Carcinogenicity of Technical-Grade Piperonyl Butoxide in F344 Rats: Selective Induction of Ileocaecal Ulcers 1985; TITLE=Lack of Evidence of Carcinogenicity of Technical-Grade Piperonyl Butoxide in F344 Rats: Selective Induction of Ileocaecal Ulcers; AUTHOR=Maekawa,A., H. Onodera, K. Furuta, H. Tanigawa, T. Ogiu, and Y. Hayashi; DOI=10.1016/0278-6915(85)90156-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75491; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Histology: Hyperplasia|Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15596694:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=014150ff5493de44aaf8a621b3591bfe |
| ToxValDB_ECOTOX | LOEL | =0.6 | % | Mouse | oral | subchronic; 56 days | subchronic | LONG_REF=Toxicol. Pathol.37(6): 761-769 Kawai,M., Y. Saegusa, M. Jin, Y. Dewa, J. Nishimura, T. Harada, M. Shibutani, and K. Mitsumori Mechanistic Study on Hepatocarcinogenesis of Piperonyl Butoxide in Mice 2009; TITLE=Mechanistic Study on Hepatocarcinogenesis of Piperonyl Butoxide in Mice; AUTHOR=Kawai,M., Y. Saegusa, M. Jin, Y. Dewa, J. Nishimura, T. Harada, M. Shibutani, and K. Mitsumori; DOI=10.1177/0192623309344087; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119664; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Biochemistry: Reactive oxygen species|Cell(s): Gamma-glutamyl transpeptidase foci|Enzyme(s): gamma-glutamyl transpeptidase|Genetics: Gene expression|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598439_15608041:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=657f9b769a9359ee377659396186b579 |
| ToxValDB_ECOTOX | LOEL | =9000 | ppm | Mouse | oral | acute; 1 days | acute | LONG_REF=Toxicology83(1-3): 93-100 Fujitani,T., T. Tanaka, Y. Hashimoto, and M. Yoneyama Subacute Toxicity of Piperonyl Butoxide in ICR Mice 1993; TITLE=Subacute Toxicity of Piperonyl Butoxide in ICR Mice; AUTHOR=Fujitani,T., T. Tanaka, Y. Hashimoto, and M. Yoneyama; DOI=10.1016/0300-483x(93)90094-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598936_15598937:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2f9b99425531726c8193a6772326967e |
| ToxValDB_ECOTOX | LOEL | =0.8 | % | Mouse | oral | subchronic; 47 days | subchronic | LONG_REF=Food Chem. Toxicol.30(12): 1015-1019 Tanaka,T., O. Takahashi, and S. Oishi Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice 1992; TITLE=Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice; AUTHOR=Tanaka,T., O. Takahashi, and S. Oishi; DOI=10.1016/0278-6915(92)90112-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599827_15599828:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d9d3b3b9081589e1337601b31a695b3a |
| ToxValDB_ECOTOX | LOEL | =0.25 | % diet | Rat | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.23(7): 675-682 Maekawa,A., H. Onodera, K. Furuta, H. Tanigawa, T. Ogiu, and Y. Hayashi Lack of Evidence of Carcinogenicity of Technical-Grade Piperonyl Butoxide in F344 Rats: Selective Induction of Ileocaecal Ulcers 1985; TITLE=Lack of Evidence of Carcinogenicity of Technical-Grade Piperonyl Butoxide in F344 Rats: Selective Induction of Ileocaecal Ulcers; AUTHOR=Maekawa,A., H. Onodera, K. Furuta, H. Tanigawa, T. Ogiu, and Y. Hayashi; DOI=10.1016/0278-6915(85)90156-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75491; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX:15600260:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fd98e4294bf0ffb8c2d8f4332daf4698 |
| ToxValDB_ECOTOX | LOEL | =2.4 | % diet | Rat | oral | short-term; 7 days | short-term | LONG_REF=Toxicology84(1-3): 171-183 Fujitani,T., Y. Tada, and M. Yoneyama Hepatotoxicity of Piperonyl Butoxide in Male F344 Rats 1993; TITLE=Hepatotoxicity of Piperonyl Butoxide in Male F344 Rats; AUTHOR=Fujitani,T., Y. Tada, and M. Yoneyama; DOI=10.1016/0300-483x(93)90115-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75192; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Enzyme(s): gamma-glutamyl transpeptidase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600383_15600384_15602803_15602804_15603574:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=370a813fe9d98422e82a4af433456f80 |
| ToxValDB_ECOTOX | LOEL | =0.3 | % | Mouse | oral | chronic (developmental) | reproduction developmental | LONG_REF=Toxicol. Lett.60(1): 83-90 Tanaka,T. Effects of Piperonyl Butoxide on F1 Generation Mice 1992; TITLE=Effects of Piperonyl Butoxide on F1 Generation Mice; AUTHOR=Tanaka,T.; DOI=10.1016/0378-4274(92)90050-t; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74888; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Behavior: Orientation; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596353_15596727_15600570_15600571_15603002_15603003:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f5b40675b66e3f825f84aaea43d19ba3 |
| ToxValDB_ECOTOX | LOEL | =3000 | ppm | Mouse | oral | short-term; 20 days | short-term | LONG_REF=Toxicology83(1-3): 93-100 Fujitani,T., T. Tanaka, Y. Hashimoto, and M. Yoneyama Subacute Toxicity of Piperonyl Butoxide in ICR Mice 1993; TITLE=Subacute Toxicity of Piperonyl Butoxide in ICR Mice; AUTHOR=Fujitani,T., T. Tanaka, Y. Hashimoto, and M. Yoneyama; DOI=10.1016/0300-483x(93)90094-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601215_15601216_15608359_15608360:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6d34404764873e785e130b8dd8c8f7b2 |
| ToxValDB_ECOTOX | LOEL | =0.4 | % | Mouse | oral | chronic; 133 days | chronic | LONG_REF=Food Chem. Toxicol.30(12): 1015-1019 Tanaka,T., O. Takahashi, and S. Oishi Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice 1992; TITLE=Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice; AUTHOR=Tanaka,T., O. Takahashi, and S. Oishi; DOI=10.1016/0278-6915(92)90112-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601539_15601540_15602584:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b896fa26a0820b0e6df4907fff5aaa43 |
| ToxValDB_ECOTOX | LOEL | =1 | % diet | Rat | oral | chronic; 770 days | chronic | LONG_REF=Food Chem. Toxicol.23(7): 675-682 Maekawa,A., H. Onodera, K. Furuta, H. Tanigawa, T. Ogiu, and Y. Hayashi Lack of Evidence of Carcinogenicity of Technical-Grade Piperonyl Butoxide in F344 Rats: Selective Induction of Ileocaecal Ulcers 1985; TITLE=Lack of Evidence of Carcinogenicity of Technical-Grade Piperonyl Butoxide in F344 Rats: Selective Induction of Ileocaecal Ulcers; AUTHOR=Maekawa,A., H. Onodera, K. Furuta, H. Tanigawa, T. Ogiu, and Y. Hayashi; DOI=10.1016/0278-6915(85)90156-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75491; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Histology: Hemorrhage|Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602454_15602455:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=65be6ac7cc855a5492666de13101029b |
| ToxValDB_ECOTOX | LOEL | =3 | mg/kg bw/day | Mouse | oral | short-term; 5 days | short-term | LONG_REF=J. Immunotoxicol.10(2): 150-159 Fukuyama,T., T. Kosaka, K. Hayashi, L. Miyashita, Y. Tajima, K. Wada, R. Nishino, H. Ueda, and T. Harada Immunotoxicity in Mice Induced by Short-Term Exposure to Methoxychlor, Parathion, or Piperonyl Butoxide 2013; TITLE=Immunotoxicity in Mice Induced by Short-Term Exposure to Methoxychlor, Parathion, or Piperonyl Butoxide; AUTHOR=Fukuyama,T., T. Kosaka, K. Hayashi, L. Miyashita, Y. Tajima, K. Wada, R. Nishino, H. Ueda, and T. Harada; DOI=10.3109/1547691X.2012.703252; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=170327; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Cell(s): B-cell; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603097_15603098:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bc8ad8008d00df8f7443b2172cefce82 |
| ToxValDB_ECOTOX | LOEL | =52 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Chem.-Biol. Interact.86(3): 255-274 Adams,N.H., P.E. Levi, and E. Hodgson Regulation of Cytochrome P-450 Isozymes by Methylenedioxyphenyl Compounds 1993; TITLE=Regulation of Cytochrome P-450 Isozymes by Methylenedioxyphenyl Compounds; AUTHOR=Adams,N.H., P.E. Levi, and E. Hodgson; DOI=10.1016/0009-2797(93)90101-4; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=74903; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Enzyme(s): 7-Ethoxyresorufin O-deethylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15604459:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9be0d0349c01975c85b885a26c47ab37 |
| ToxValDB_ECOTOX | LOEL | =2 | % diet | Rat | oral | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.23(7): 675-682 Maekawa,A., H. Onodera, K. Furuta, H. Tanigawa, T. Ogiu, and Y. Hayashi Lack of Evidence of Carcinogenicity of Technical-Grade Piperonyl Butoxide in F344 Rats: Selective Induction of Ileocaecal Ulcers 1985; TITLE=Lack of Evidence of Carcinogenicity of Technical-Grade Piperonyl Butoxide in F344 Rats: Selective Induction of Ileocaecal Ulcers; AUTHOR=Maekawa,A., H. Onodera, K. Furuta, H. Tanigawa, T. Ogiu, and Y. Hayashi; DOI=10.1016/0278-6915(85)90156-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75491; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601687_15605757_15605758:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=46ff9d22019944e3b72c00d862e4977a |
| ToxValDB_ECOTOX | LOEL | =1 | % | Rat | oral | subchronic; 42 days | subchronic | LONG_REF=Toxicology236(1-2): 61-75 Muguruma,M., A. Unami, M. Kanki, Y. Kuroiwa, J. Nishimura, Y. Dewa, T. Umemura, Y. Oishi, and K. Mitsumori Possible Involvement of Oxidative Stress in Piperonyl Butoxide Induced Hepatocarcinogenesis in Rats 2007; TITLE=Possible Involvement of Oxidative Stress in Piperonyl Butoxide Induced Hepatocarcinogenesis in Rats; AUTHOR=Muguruma,M., A. Unami, M. Kanki, Y. Kuroiwa, J. Nishimura, Y. Dewa, T. Umemura, Y. Oishi, and K. Mitsumori; DOI=10.1016/j.tox.2007.03.025; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119669; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Biochemistry: Reactive oxygen species|Enzyme(s): Glutathione S-transferase|Genetics: Cyp1A1 mRNA|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|other; STUDY_GROUP=ECOTOX:15606993:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=776a3f9cd928249d9f2cf6a619a04aff |
| ToxValDB_ECOTOX | LOEL | =338 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Pestic. Biochem. Physiol.46(1): 15-26 Adams,N.H., P.E. Levi, and E. Hodgson Differences in Induction of Three P450 Isozymes by Piperonyl Butoxide, Sesamex, Safrole, and Isosafrole 1993; TITLE=Differences in Induction of Three P450 Isozymes by Piperonyl Butoxide, Sesamex, Safrole, and Isosafrole; AUTHOR=Adams,N.H., P.E. Levi, and E. Hodgson; DOI=10.1006/pest.1993.1032; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=74902; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Enzyme(s): 7-Ethoxyresorufin O-deethylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15608885:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f23a2208aa545ae9e917c0644719bfb3 |
| ToxValDB_ECOTOX | LOEL | =537 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=- | Fundam. Appl. Toxicol.22(2): 293-303 Takahashi,O., S. Oishi, T. Fujitani, T. Tanaka, and M. Yoneyama Chronic Toxicity Studies of Piperonyl Butoxide in F344 Rats: Induction of Hepatocellular carcinoma 1994; TITLE=Chronic Toxicity Studies of Piperonyl Butoxide in F344 Rats: Induction of Hepatocellular carcinoma; AUTHOR=Takahashi,O., S. Oishi, T. Fujitani, T. Tanaka, and M. Yoneyama; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74868; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Essential thrombocythemia, Cecum englargement, Kidneys black-colored, relative and absolute liver weight, hemagological parameters, plasma biochemical parameters; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=ECOTOX:15612944:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=93041a75927d60ae7fcabd8a8bfcccfc |
| ToxValDB_ECOTOX | LOEL | =1.97 | mg/kg bw/day | Mouse | oral | subchronic; 42 days | subchronic | LONG_REF=- | Fundam. Appl. Toxicol.38(1): 64-74 Phillips,J.C., R.J. Price, M.E. Cunninghame, T.G. Osimitz, A. Cockburn, K.L. Gabriel, F.J. Preiss, W.H. Butler, and B.G Effect of Piperonyl Butoxide on Cell Replication and Xenobiotic Metabolism in the Livers of CD-1 Mice and F344 Rats 1997; TITLE=Effect of Piperonyl Butoxide on Cell Replication and Xenobiotic Metabolism in the Livers of CD-1 Mice and F344 Rats; AUTHOR=Phillips,J.C., R.J. Price, M.E. Cunninghame, T.G. Osimitz, A. Cockburn, K.L. Gabriel, F.J. Preiss, W.H. Butler, and B.G; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74869; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Enzyme(s): 7-Ethoxyresorufin O-deethylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15613087:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=0ca56f578b6aac1e238ea8b8e1f7d6f9 |
| ToxValDB_ECOTOX | LOEL | =1182 | mg/kg bw/day | Mouse | oral | subchronic; 8 weeks | subchronic | LONG_REF=- | Toxicology228(2-3): 178-187 Muguruma,M., J. Nishimura, M. Jin, Y. Kashida, M. Moto, M. Takahashi, Y. Yokouchi, and K. Mitsumori Molecular Pathological Analysis for Determining the Possible Mechanism of Piperonyl Butoxide-Induced Hepatocarcinogenesis in Mice 2006; TITLE=Molecular Pathological Analysis for Determining the Possible Mechanism of Piperonyl Butoxide-Induced Hepatocarcinogenesis in Mice; AUTHOR=Muguruma,M., J. Nishimura, M. Jin, Y. Kashida, M. Moto, M. Takahashi, Y. Yokouchi, and K. Mitsumori; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119668; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Body weight and weight gain | Liver weight: absolute and relative | Abnormal histopathology| mRNA expression of genes related to oxidative and metabolic stress, proliferation, carcinogenesis, DNA damage and repair; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight|other; STUDY_GROUP=ECOTOX:15613156:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=85efa0cb2484e02859bb3bcf9c196fc2 |
| ToxValDB_ECOTOX | LOEL | =1560 | mg/kg bw/day | Rat | oral | chronic; 91 days | chronic | LONG_REF=- | J. Toxicol. Sci.36(5): 507-514 Nemoto,K., T. Tanaka, A. Ikeda, S. Ito, M. Mizukami, T. Hikida, T. Gamou, W. Habano, S. Ozawa, K. Inoue, M. Yoshida, A. Super-Induced Gene Expression of the N-Methyl-D-Aspartate Receptor 2C Subunit in Chemical-Induced Hypertrophic Liver in Rats 2011; TITLE=Super-Induced Gene Expression of the N-Methyl-D-Aspartate Receptor 2C Subunit in Chemical-Induced Hypertrophic Liver in Rats; AUTHOR=Nemoto,K., T. Tanaka, A. Ikeda, S. Ito, M. Mizukami, T. Hikida, T. Gamou, W. Habano, S. Ozawa, K. Inoue, M. Yoshida, A.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=170324; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Genetics: Glutamate receptor, ionotropic, N-methyl D-aspartate 2C mRNA|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|other; STUDY_GROUP=ECOTOX:15613160:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=ea58497e23b1c480ec2f72e58e42768b |
| ToxValDB_ECOTOX | LOEL | =20000 | ppm | Rat | oral | short-term; 28 days | short-term | LONG_REF=- | J. Toxicol. Sci.38(6): 891-902 Hayashi,S., Y. Taketa, K. Inoue, M. Takahashi, S. Matsuo, K. Irie, G. Watanabe, and M. Yoshida Effects of Pyperonyl Butoxide on the Female Reproductive Tract in Rats 2013; TITLE=Effects of Pyperonyl Butoxide on the Female Reproductive Tract in Rats; AUTHOR=Hayashi,S., Y. Taketa, K. Inoue, M. Takahashi, S. Matsuo, K. Irie, G. Watanabe, and M. Yoshida; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=170283; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15613168:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=c7e899b9c93c8c5e14e915f2a14e525f |
| ToxValDB_ECOTOX | LOEL | =9.6 | mg/kg bw/day | Rat | oral | subchronic; 42 days | subchronic | LONG_REF=- | Fundam. Appl. Toxicol.38(1): 64-74 Phillips,J.C., R.J. Price, M.E. Cunninghame, T.G. Osimitz, A. Cockburn, K.L. Gabriel, F.J. Preiss, W.H. Butler, and B.G Effect of Piperonyl Butoxide on Cell Replication and Xenobiotic Metabolism in the Livers of CD-1 Mice and F344 Rats 1997; TITLE=Effect of Piperonyl Butoxide on Cell Replication and Xenobiotic Metabolism in the Livers of CD-1 Mice and F344 Rats; AUTHOR=Phillips,J.C., R.J. Price, M.E. Cunninghame, T.G. Osimitz, A. Cockburn, K.L. Gabriel, F.J. Preiss, W.H. Butler, and B.G; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74869; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Morphology: liver weight in relationship to body weight| Enzyme activity; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight|urinalysis; STUDY_GROUP=ECOTOX:15613265:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=9ffd5a5f2ce8e11ba2bba596437c971c |
| ToxValDB_ECOTOX | LOEL | =547 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=- | Fundam. Appl. Toxicol.22(2): 293-303 Takahashi,O., S. Oishi, T. Fujitani, T. Tanaka, and M. Yoneyama Chronic Toxicity Studies of Piperonyl Butoxide in F344 Rats: Induction of Hepatocellular carcinoma 1994; TITLE=Chronic Toxicity Studies of Piperonyl Butoxide in F344 Rats: Induction of Hepatocellular carcinoma; AUTHOR=Takahashi,O., S. Oishi, T. Fujitani, T. Tanaka, and M. Yoneyama; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74868; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=hyperplastic and neoplastic nodular lesions in livers, essential thrombocythemia, cecum englargement and edema, cecum hemorrhages, hematological parameters, plasma biochemical parameters; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15613409:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=06043bb3a4bb59e7815544ab44df87ee |
| ToxValDB_ECOTOX | LOEL | =1065 | mg/kg bw/day | Mouse | oral | short-term; 10 days | reproduction developmental | LONG_REF=- | Toxicol. Lett.71(2): 123-129 Tanaka,T., T. Fujitani, O. Takahashi, and S. Oishi Developmental Toxicity Evaluation of Piperonyl Butoxide in CD-1 Mice 1994; TITLE=Developmental Toxicity Evaluation of Piperonyl Butoxide in CD-1 Mice; AUTHOR=Tanaka,T., T. Fujitani, O. Takahashi, and S. Oishi; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=74889; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Reproduction: female fetus body weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15613507:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=bed1694b8cfc05f5141ada5549495add |
| ToxValDB_ECOTOX | LOEL | =0.03 | % | Mouse | oral | - | reproduction developmental | LONG_REF=- | Food Addit. Contam.20(3): 207-214 Tanaka,T. Reproductive and Neurobehavioural Effects of Piperonyl Butoxide Administered to Mice in the Diet 2003; TITLE=Reproductive and Neurobehavioural Effects of Piperonyl Butoxide Administered to Mice in the Diet; AUTHOR=Tanaka,T.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119699; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=behavioral development: surface righting, olfactory orientation| movement activity of exploratory behavior: total distance; STUDY_GROUP=ECOTOX:15613608:M:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=d8618429a8801015927aa85ae06fc21e |
| ToxValDB_ECOTOX | LOEL | =93.2 | mg/kg bw/day | Mouse | oral | chronic; 140 days | reproduction developmental | LONG_REF=- | Toxicol. Ind. Health25(7): 489-497 Tanaka,T., O. Takahashi, S. Oishi, and A. Ogata Effects of Piperonyl Butoxide on Spontaneous Behavior in F1-Generation Mice 2009; TITLE=Effects of Piperonyl Butoxide on Spontaneous Behavior in F1-Generation Mice; AUTHOR=Tanaka,T., O. Takahashi, S. Oishi, and A. Ogata; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119622; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Body weight at PND 0, decreased; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15613632:M:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=4edaad7e8593d4dc765135100fb1aba7 |
| ToxValDB_ECOTOX | LOEL | =0.01 | % | Mouse | oral | - | reproduction developmental | LONG_REF=- | Food Addit. Contam.20(3): 207-214 Tanaka,T. Reproductive and Neurobehavioural Effects of Piperonyl Butoxide Administered to Mice in the Diet 2003; TITLE=Reproductive and Neurobehavioural Effects of Piperonyl Butoxide Administered to Mice in the Diet; AUTHOR=Tanaka,T.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119699; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=behavioral development: olfactory orientation; STUDY_GROUP=ECOTOX:15613634:F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=84630c26a7dbc8c038acd7b0d51e8a41 |
| ToxValDB_ECOTOX | NOEL | =0.05 | % | Rat | oral | short-term; 14 days | short-term | LONG_REF=Arch. Toxicol.72(11): 744-750 Okamiya,H., K. Mitsumori, H. Onodera, S. Ito, T. Imazawa, K. Yasuhara, and M. Takahashi Mechanistic Study on Liver Tumor Promoting Effects of Piperonyl Butoxide in Rats 1998; TITLE=Mechanistic Study on Liver Tumor Promoting Effects of Piperonyl Butoxide in Rats; AUTHOR=Okamiya,H., K. Mitsumori, H. Onodera, S. Ito, T. Imazawa, K. Yasuhara, and M. Takahashi; DOI=10.1007/s002040050569; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74865; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594080_15594081_15600785_15610538_15610569:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=98ffbeadb958d3627eb9a91853f96bfb |
| ToxValDB_ECOTOX | NOEL | =2 | % | Rat | oral | short-term; 2 days | short-term | LONG_REF=Arch. Toxicol.72(11): 744-750 Okamiya,H., K. Mitsumori, H. Onodera, S. Ito, T. Imazawa, K. Yasuhara, and M. Takahashi Mechanistic Study on Liver Tumor Promoting Effects of Piperonyl Butoxide in Rats 1998; TITLE=Mechanistic Study on Liver Tumor Promoting Effects of Piperonyl Butoxide in Rats; AUTHOR=Okamiya,H., K. Mitsumori, H. Onodera, S. Ito, T. Imazawa, K. Yasuhara, and M. Takahashi; DOI=10.1007/s002040050569; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74865; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Cell(s): Cell changes|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECOTOX:15594082:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2dbefd144426777afa81d1d42e857e60 |
| ToxValDB_ECOTOX | NOEL | =0.6 | % | Mouse | oral | chronic; 365 days | chronic | LONG_REF=Toxicol. Pathol.26(2): 301-303 Takahashi,O., S. Oishi, M. Yoneyama, T. Tanaka, and T. Fujitani Mouse Liver Nodules Induced by Piperonyl Butoxide, a Mixed-Function Oxidase Inducer 1998; TITLE=Mouse Liver Nodules Induced by Piperonyl Butoxide, a Mixed-Function Oxidase Inducer; AUTHOR=Takahashi,O., S. Oishi, M. Yoneyama, T. Tanaka, and T. Fujitani; DOI=10.1177/019262339802600219; QUALITY=Control type: Control data is presented but without accompanying methodology; EXTERNAL_SOURCE_ID=75518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Injury: Injury, general; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594252_15594253_15598843:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6818bddc175d10b7bf652bbe74409620 |
| ToxValDB_ECOTOX | NOEL | =1.2 | % | Rat | oral | chronic; 91 days | chronic | LONG_REF=Toxicology72(3): 291-298 Fujitani,T., H. Ando, K. Fujitani, T. Ikeda, A. Kojima, Y. Kubo, A. Ogata, S. Oishi, H. Takahashi, O. Takahashi, and M. Sub-Acute Toxicity of Piperonyl Butoxide in F344 Rats 1992; TITLE=Sub-Acute Toxicity of Piperonyl Butoxide in F344 Rats; AUTHOR=Fujitani,T., H. Ando, K. Fujitani, T. Ikeda, A. Kojima, Y. Kubo, A. Ogata, S. Oishi, H. Takahashi, O. Takahashi, and M.; DOI=10.1016/0300-483x(92)90180-m; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119340; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Enzyme(s): gamma-glutamyl transpeptidase|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594334_15594335_15594336_15594337_15605363:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ae15e7d3ba592540e063b7aebe908337 |
| ToxValDB_ECOTOX | NOEL | =100 | mg/kg bw/day | Mouse | injection | short-term; 3 days | short-term | LONG_REF=Gen. Pharmacol.11(5): 429-435 Fabacher,D.L., A.P. Kulkarni, and E. Hodgson Pesticides as Inducers of Hepatic Drug-Metabolizing Enzymes - I. Mixed Function Oxidase Activity 1980; TITLE=Pesticides as Inducers of Hepatic Drug-Metabolizing Enzymes - I. Mixed Function Oxidase Activity; AUTHOR=Fabacher,D.L., A.P. Kulkarni, and E. Hodgson; DOI=10.1016/0306-3623(80)90028-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=92612; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P-450|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594417_15596938:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=452135692c81108ccef705fa60e71a91 |
| ToxValDB_ECOTOX | NOEL | =400 | mg/kg bw/day | Rat | injection | short-term; 4 days | short-term | LONG_REF=Toxicol. Sci.46(1): 185-196 Ratra,G.S., S. Cottrell, and C.J. Powell Effects of Induction and Inhibition of Cytochromes P450 on the Hepatotoxicity of Methapyrilene 1998; TITLE=Effects of Induction and Inhibition of Cytochromes P450 on the Hepatotoxicity of Methapyrilene; AUTHOR=Ratra,G.S., S. Cottrell, and C.J. Powell; DOI=10.1006/toxs.1998.2513; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=74906; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECOTOX:15594971:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=80b50a0ce46c8f661fd17b6182f77fed |
| ToxValDB_ECOTOX | NOEL | =500 | mg/kg bw/day | Rat | oral | acute; 0.5417 days | acute | LONG_REF=Psychopharmacology89(3): 278-283 Herr,D.W., J.S. Hong, P. Chen, H.A. Tilson, and G.J. Harry Pharmacological Modification of DDT-Induced Tremor and Hyperthermia in Rats: Distributional Factors 1986; TITLE=Pharmacological Modification of DDT-Induced Tremor and Hyperthermia in Rats: Distributional Factors; AUTHOR=Herr,D.W., J.S. Hong, P. Chen, H.A. Tilson, and G.J. Harry; DOI=10.1007/bf00174359; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=99912; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Intoxication: Convulsions|Physiology: Body temperature; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595983_15609130:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a314c73e4038a17ab1c2c4526a6043a2 |
| ToxValDB_ECOTOX | NOEL | =200 | mg/kg bw/day | Rat | injection | acute; 0.5 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.103(3): 420-429 Chambers,J.E., and H.W. Chambers Time Course of Inhibition of Acetylcholinesterase and Aliesterases Following Parathion and Paraoxon Exposures in Rats 1990; TITLE=Time Course of Inhibition of Acetylcholinesterase and Aliesterases Following Parathion and Paraoxon Exposures in Rats; AUTHOR=Chambers,J.E., and H.W. Chambers; DOI=10.1016/0041-008x(90)90315-l; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=74887; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Enzyme(s): Cytochrome P-450|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight|urinalysis; STUDY_GROUP=ECOTOX:15598265:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0a1b4b1276922e7124f56a148ab1f20d |
| ToxValDB_ECOTOX | NOEL | =3000 | ppm | Mouse | oral | acute; 1 days | acute | LONG_REF=Toxicology83(1-3): 93-100 Fujitani,T., T. Tanaka, Y. Hashimoto, and M. Yoneyama Subacute Toxicity of Piperonyl Butoxide in ICR Mice 1993; TITLE=Subacute Toxicity of Piperonyl Butoxide in ICR Mice; AUTHOR=Fujitani,T., T. Tanaka, Y. Hashimoto, and M. Yoneyama; DOI=10.1016/0300-483x(93)90094-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598936_15598937:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=67a3c6374729b2e51adfd0a96601be47 |
| ToxValDB_ECOTOX | NOEL | =0.4 | % | Mouse | oral | subchronic; 47 days | subchronic | LONG_REF=Food Chem. Toxicol.30(12): 1015-1019 Tanaka,T., O. Takahashi, and S. Oishi Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice 1992; TITLE=Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice; AUTHOR=Tanaka,T., O. Takahashi, and S. Oishi; DOI=10.1016/0278-6915(92)90112-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599827_15599828:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6a9400233273e43ed663262f8351d745 |
| ToxValDB_ECOTOX | NOEL | =1.2 | % diet | Rat | oral | short-term; 7 days | short-term | LONG_REF=Toxicology84(1-3): 171-183 Fujitani,T., Y. Tada, and M. Yoneyama Hepatotoxicity of Piperonyl Butoxide in Male F344 Rats 1993; TITLE=Hepatotoxicity of Piperonyl Butoxide in Male F344 Rats; AUTHOR=Fujitani,T., Y. Tada, and M. Yoneyama; DOI=10.1016/0300-483x(93)90115-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75192; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Enzyme(s): gamma-glutamyl transpeptidase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600383_15600384_15602803_15602804_15603574:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f84b87e0bb2a6ca30a7c5d806463760c |
| ToxValDB_ECOTOX | NOEL | =1000 | ppm | Mouse | oral | short-term; 20 days | short-term | LONG_REF=Toxicology83(1-3): 93-100 Fujitani,T., T. Tanaka, Y. Hashimoto, and M. Yoneyama Subacute Toxicity of Piperonyl Butoxide in ICR Mice 1993; TITLE=Subacute Toxicity of Piperonyl Butoxide in ICR Mice; AUTHOR=Fujitani,T., T. Tanaka, Y. Hashimoto, and M. Yoneyama; DOI=10.1016/0300-483x(93)90094-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601215_15601216_15608359_15608360:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c86c5c835a56106bd9ab68c4e10eb223 |
| ToxValDB_ECOTOX | NOEL | =0.2 | % | Mouse | oral | chronic; 133 days | chronic | LONG_REF=Food Chem. Toxicol.30(12): 1015-1019 Tanaka,T., O. Takahashi, and S. Oishi Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice 1992; TITLE=Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice; AUTHOR=Tanaka,T., O. Takahashi, and S. Oishi; DOI=10.1016/0278-6915(92)90112-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601539_15601540_15602584:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bf30f520dbd08651ea232f96c6ded3ad |
| ToxValDB_ECOTOX | NOEL | =1360 | mg/kg bw/day | Rat | injection | short-term; 2 days | short-term | LONG_REF=J. Toxicol. Environ. Health Part A64(3): 241-256 Hong,S.K., D.K. Anestis, M.A. Valentovic, J.G. Ball, P.I. Brown, and G.O. Rankin Gender Differences in the Potentiation of N-(3,5-Dichlorophenyl)Succinimide Metabolite Nephrotoxicity by Phenobarbital 2001; TITLE=Gender Differences in the Potentiation of N-(3,5-Dichlorophenyl)Succinimide Metabolite Nephrotoxicity by Phenobarbital; AUTHOR=Hong,S.K., D.K. Anestis, M.A. Valentovic, J.G. Ball, P.I. Brown, and G.O. Rankin; DOI=10.1080/15287390152543717; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=74922; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Biochemistry: Blood urea nitrogen|Physiology: Excretion rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15601662:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b919ead429225ea281d91487b2faf3db |
| ToxValDB_ECOTOX | NOEL | =0.8 | % | Mouse | oral | chronic; 133 days | chronic | LONG_REF=Food Chem. Toxicol.30(12): 1015-1019 Tanaka,T., O. Takahashi, and S. Oishi Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice 1992; TITLE=Reproductive and Neurobehavioural Effects in Three-Generation Toxicity Study of Piperonyl Butoxide Administered to Mice; AUTHOR=Tanaka,T., O. Takahashi, and S. Oishi; DOI=10.1016/0278-6915(92)90112-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Population: Sex ratio; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601539_15601540_15602584:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dbe9e875c990356884842fcea6fa3384 |
| ToxValDB_ECOTOX | NOEL | =0.6 | % diet | Rat | oral | short-term; 7 days | short-term | LONG_REF=Toxicology84(1-3): 171-183 Fujitani,T., Y. Tada, and M. Yoneyama Hepatotoxicity of Piperonyl Butoxide in Male F344 Rats 1993; TITLE=Hepatotoxicity of Piperonyl Butoxide in Male F344 Rats; AUTHOR=Fujitani,T., Y. Tada, and M. Yoneyama; DOI=10.1016/0300-483x(93)90115-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75192; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600383_15600384_15602803_15602804_15603574:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=810610dee2b2413c92354f4d40ddabf4 |
| ToxValDB_ECOTOX | NOEL | =300 | mg/kg bw/day | Mouse | oral | short-term; 5 days | short-term | LONG_REF=J. Immunotoxicol.10(2): 150-159 Fukuyama,T., T. Kosaka, K. Hayashi, L. Miyashita, Y. Tajima, K. Wada, R. Nishino, H. Ueda, and T. Harada Immunotoxicity in Mice Induced by Short-Term Exposure to Methoxychlor, Parathion, or Piperonyl Butoxide 2013; TITLE=Immunotoxicity in Mice Induced by Short-Term Exposure to Methoxychlor, Parathion, or Piperonyl Butoxide; AUTHOR=Fukuyama,T., T. Kosaka, K. Hayashi, L. Miyashita, Y. Tajima, K. Wada, R. Nishino, H. Ueda, and T. Harada; DOI=10.3109/1547691X.2012.703252; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=170327; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Immunological: Immunoglobulin M; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603097_15603098:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=051980c82e3ba62e23ff429c30659004 |
| ToxValDB_ECOTOX | NOEL | =630 | mg/kg bw/day | Rat | oral | short-term; 2 days | developmental | LONG_REF=- | Toxicol. Ind. Health11(2): 175-184 Tanaka,T., T. Fujitani, O. Takahashi, S. Oishi, and M. Yoneyama Developmental Toxicity Study of Piperonyl Butoxide in CD Rats 1995; TITLE=Developmental Toxicity Study of Piperonyl Butoxide in CD Rats; AUTHOR=Tanaka,T., T. Fujitani, O. Takahashi, S. Oishi, and M. Yoneyama; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119368; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight|Growth: Weight gain|Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|reproduction; STUDY_GROUP=ECOTOX:15613381:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=d7cca1831d1e92a39ad72b30fffa84bc |
| ToxValDB_ECOTOX | NOEL | =274.2 | mg/kg bw/day | Mouse | oral | subchronic; 77 days | reproduction developmental | LONG_REF=- | Toxicol. Ind. Health25(7): 489-497 Tanaka,T., O. Takahashi, S. Oishi, and A. Ogata Effects of Piperonyl Butoxide on Spontaneous Behavior in F1-Generation Mice 2009; TITLE=Effects of Piperonyl Butoxide on Spontaneous Behavior in F1-Generation Mice; AUTHOR=Tanaka,T., O. Takahashi, S. Oishi, and A. Ogata; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119622; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15613605:M:P0-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=3d62181e935fcb0d89fbaaab229d66c8 |
| ToxValDB_ECOTOX | NOEL | =313.2 | mg/kg bw/day | Mouse | oral | subchronic; 77 days | reproduction developmental | LONG_REF=- | Toxicol. Ind. Health25(7): 489-497 Tanaka,T., O. Takahashi, S. Oishi, and A. Ogata Effects of Piperonyl Butoxide on Spontaneous Behavior in F1-Generation Mice 2009; TITLE=Effects of Piperonyl Butoxide on Spontaneous Behavior in F1-Generation Mice; AUTHOR=Tanaka,T., O. Takahashi, S. Oishi, and A. Ogata; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119622; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Reproduction: Pregnant, litter size, litter weight, sex ratio | Movement activity; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior|reproduction; STUDY_GROUP=ECOTOX:15613617:F:P0-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=9ba74cd9df022e1360d4eba96f01c230 |
| ToxValDB_ECOTOX | NOEL | =0.09 | % | Mouse | oral | short-term; 4 weeks | reproduction developmental | LONG_REF=- | Food Addit. Contam.20(3): 207-214 Tanaka,T. Reproductive and Neurobehavioural Effects of Piperonyl Butoxide Administered to Mice in the Diet 2003; TITLE=Reproductive and Neurobehavioural Effects of Piperonyl Butoxide Administered to Mice in the Diet; AUTHOR=Tanaka,T.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=119699; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15613631:M:F0-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=693e9aee665aa95e41e8599acb88ef3c |
ToxValDB_EPA_OPP 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_OPP | PAD (RfD) | =5 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15789954_15789956:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f50e0bddaeea7303af189bdb885f4125 |
| ToxValDB_EPA_OPP | PAD (RfD) | =0.16 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15789954_15789956:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fda86bdad8f7ad18ea67d7a4899eb55e |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =3.875 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634203_15634204_15634205:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed539411fcfa6a086bb60619b102c247 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634203_15634204_15634205:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4a0d52fa19b927a59fa0c1e734b1abf9 |
ToxValDB_ToxRefDB 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =100 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Leng, J. (1986) Teratology Study in Rabbits [Using Piperonyl Butoxide]: Study No. 542-002. Unpublished study prepared by International Research and Development Corp. 61 p.; TITLE=Teratology Study in Rabbits [Using Piperonyl Butoxide]; AUTHOR=Leng, J; EXTERNAL_SOURCE_ID=3748; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-defecation|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15704056_15704057_15704058_15704059:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f91057978109e2f03a32417971adb54f |
| ToxValDB_ToxRefDB | LEL | =500 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Chun, J.; Neeper-Bradley, T. (1991) Developmental Toxicity Evaluation of Piperonyl Butoxide Administered by Gavage to CD (Sprague-Dawley) Rats: Lab Project Number: 54-586. Unpublished study prepared by Bushy Run Research Center. 283 p.; TITLE=Developmental Toxicity Evaluation of Piperonyl Butoxide Administered by Gavage to CD (Sprague-Dawley) Rats: Lab Project Number: 54-586; AUTHOR=Chun, J.; Neeper-Bradley, T; EXTERNAL_SOURCE_ID=3749; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-red or crusty deposits around eyes, ears, nose, or mouth|systemic: in life observation-clinical signs-urine staining - perineum|systemic: in life observation-clinical signs-wetness|systemic: in life observation-clinical signs-hemorrhagic perineal discharge; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15704064_15704065_15704066_15704067:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03c387bf4924c6b66adf95a18085410d |
| ToxValDB_ToxRefDB | LEL | >469 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robinson, K.; Pinsonneault, L.; Procter, B. (1986) A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat. Research Report: Project No. 81689. Unpublished study prepared by Bio-Research Laboratories.; TITLE=A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat; AUTHOR=Robinson, K.; Pinsonneault, L.; Procter, B; EXTERNAL_SOURCE_ID=3750; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ToxRefDB_dup_-_15704072_15704073_15704074_15704075:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87c72f0c7e8e1a26f18eb11aad59cc91 |
| ToxValDB_ToxRefDB | LEL | =528 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robinson, K.; Pinsonneault, L.; Procter, B. (1986) A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat. Research Report: Project No. 81689. Unpublished study prepared by Bio-Research Laboratories.; TITLE=A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat; AUTHOR=Robinson, K.; Pinsonneault, L.; Procter, B; EXTERNAL_SOURCE_ID=3750; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-offspring (pup) weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15704096_15704097_15704098_15704099:F:F2juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf487204b6f5d73bd799c7aca6d55841 |
| ToxValDB_ToxRefDB | LEL | =16.3 | mg/kg bw/day | Dog | oral | chronic; 12 months | chronic | LONG_REF=Goldenthal, E. (1993) Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004. Unpublished study prepared by International Research and Development Corp. 326 p.; TITLE=Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=3751; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15704104_15704105_15704106_15704107:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6046b35e54ecdad3a37d3aba3eb9a06a |
| ToxValDB_ToxRefDB | LEL | =15.5 | mg/kg bw/day | Dog | oral | chronic; 12 months | chronic | LONG_REF=Goldenthal, E. (1993) Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004. Unpublished study prepared by International Research and Development Corp. 326 p.; TITLE=Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=3751; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: in life observation-food consumption-food consumption|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hypertrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15704108_15704109_15704110_15704111:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec258a5b0b35519b56b19c8a1604f7fb |
| ToxValDB_ToxRefDB | LEL | =250 | mg/kg bw/day | Rat | oral | chronic; 107 weeks | chronic | LONG_REF=BIOASSAY OF PIPERONYL BUTOXIDE FOR POSSIBLE CARCINOGENICITY CAS No. 51-03-6. Study No: NCI-CG-TR-120, DHEW Publication No. (NIH) 79-1375. (Rat portion); TITLE=BIOASSAY OF PIPERONYL BUTOXIDE FOR POSSIBLE CARCINOGENICITY CAS No. 51-03-6; AUTHOR=NCI; EXTERNAL_SOURCE_ID=7447; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology gross-full gross necropsy-lymphoma nos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer; STUDY_GROUP=ToxRefDB_dup_-_15712651_15712652_15712653:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4085a0baabff870c05f400bfb9bc765b |
| ToxValDB_ToxRefDB | LEL | =155.4 | mg/kg bw/day | Mouse | oral | chronic; 112 weeks | chronic | LONG_REF=BIOASSAY OF PIPERONYL BUTOXIDE FOR POSSIBLE CARCINOGENICITY CAS No. 51-03-6. Study No: NCI-CG-TR-120, DHEW Publication No. (NIH) 79-1375. (Mouse portion); TITLE=BIOASSAY OF PIPERONYL BUTOXIDE FOR POSSIBLE CARCINOGENICITY CAS No. 51-03-6; AUTHOR=NCI; EXTERNAL_SOURCE_ID=7448; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-alopecia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15712657_15712658:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b782019906fdce66c86f540b0bcbf89c |
| ToxValDB_ToxRefDB | LOAEL | >200 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Leng, J. (1986) Teratology Study in Rabbits [Using Piperonyl Butoxide]: Study No. 542-002. Unpublished study prepared by International Research and Development Corp. 61 p.; TITLE=Teratology Study in Rabbits [Using Piperonyl Butoxide]; AUTHOR=Leng, J; EXTERNAL_SOURCE_ID=3748; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ToxRefDB_dup_-_15704056_15704057_15704058_15704059:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b89dc0910183a217cef3ce10d5855c93 |
| ToxValDB_ToxRefDB | LOAEL | =100 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Graham, C.; Bujold, H. (1987) 24-Month Dietary Toxicity and Carcinogenicity Study of Piperonyl Butoxide in the Albino Rat: Lab. Proj. ID 81690. Unpublished study prepared by Bio-Research Laboratories Ltd. 2576 p.; TITLE=24-Month Dietary Toxicity and Carcinogenicity Study of Piperonyl Butoxide in the Albino Rat; AUTHOR=Graham, C.; Bujold, H; EXTERNAL_SOURCE_ID=3755; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: clinical chemistry-cholesterol-cholesterol|systemic: pathology microscopic-liver-mixed cell focus|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-relative to brain weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15704119_15704120_15704121_15704122:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c2ba03621c7769959022a946900d129 |
| ToxValDB_ToxRefDB | NEL | =50 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Leng, J. (1986) Teratology Study in Rabbits [Using Piperonyl Butoxide]: Study No. 542-002. Unpublished study prepared by International Research and Development Corp. 61 p.; TITLE=Teratology Study in Rabbits [Using Piperonyl Butoxide]; AUTHOR=Leng, J; EXTERNAL_SOURCE_ID=3748; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-defecation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15704056_15704057_15704058_15704059:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fef7bf96bca96443fcb958f3764a8cb8 |
| ToxValDB_ToxRefDB | NEL | =102 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robinson, K.; Pinsonneault, L.; Procter, B. (1986) A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat. Research Report: Project No. 81689. Unpublished study prepared by Bio-Research Laboratories.; TITLE=A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat; AUTHOR=Robinson, K.; Pinsonneault, L.; Procter, B; EXTERNAL_SOURCE_ID=3750; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15704072_15704073_15704074_15704075:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_61cffb68e743c7c20d56f62a95420ec3 |
| ToxValDB_ToxRefDB | NEL | =89 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robinson, K.; Pinsonneault, L.; Procter, B. (1986) A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat. Research Report: Project No. 81689. Unpublished study prepared by Bio-Research Laboratories.; TITLE=A Two-generation (Two-litter) Reproduction Study of Piperonyl Butoxide Admin- istered in the Diet to the Rat; AUTHOR=Robinson, K.; Pinsonneault, L.; Procter, B; EXTERNAL_SOURCE_ID=3750; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15704076_15704077_15704078_15704079:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d81c7620d21e766115e73248d4405774 |
| ToxValDB_ToxRefDB | NEL | =2.7 | mg/kg bw/day | Dog | oral | chronic; 12 months | chronic | LONG_REF=Goldenthal, E. (1993) Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004. Unpublished study prepared by International Research and Development Corp. 326 p.; TITLE=Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=3751; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15704104_15704105_15704106_15704107:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b3f99b0c52593b685ca449fce6332e6 |
| ToxValDB_ToxRefDB | NEL | =2.9 | mg/kg bw/day | Dog | oral | chronic; 12 months | chronic | LONG_REF=Goldenthal, E. (1993) Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004. Unpublished study prepared by International Research and Development Corp. 326 p.; TITLE=Evaluation of Piperonyl Butoxide in an Eight Week Toxicity Study in Dogs: Lab Project Number: 542-004; AUTHOR=Goldenthal, E; EXTERNAL_SOURCE_ID=3751; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: pathology microscopic-liver-hypertrophy|systemic: organ weight-liver-relative to body weight|systemic: in life observation-food consumption-food consumption|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15704108_15704109_15704110_15704111:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f8f2314759a3f674aec8c5770633b71 |
| ToxValDB_ToxRefDB | NEL | =15 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Graham, C.; Bujold, H. (1987) 24-Month Dietary Toxicity and Carcinogenicity Study of Piperonyl Butoxide in the Albino Rat: Lab. Proj. ID 81690. Unpublished study prepared by Bio-Research Laboratories Ltd. 2576 p.; TITLE=24-Month Dietary Toxicity and Carcinogenicity Study of Piperonyl Butoxide in the Albino Rat; AUTHOR=Graham, C.; Bujold, H; EXTERNAL_SOURCE_ID=3755; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-protein-protein|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-hypertrophy|systemic: clinical chemistry-cholesterol-cholesterol|systemic: pathology microscopic-liver-mixed cell focus|systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|systemic: pathology gross-liver-mass|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-liver-discolored|systemic: organ weight-liver-relative to brain weight|systemic: pathology microscopic-thyroid gland-pigmentation|systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: pathology gross-liver-accentuated lobular pattern|systemic: pathology gross-liver-irregular surface; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15704119_15704120_15704121_15704122:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c22b5e714ef3a7d913385bdfb816f5a2 |
ToxValDB_Uterotrophic_Hershberger_DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Uterotrophic_Hershberger_DB | NOEL | =500 | mg/kg bw/day | Rat | oral | short-term; 10 days | Hershberger | LONG_REF=Piperonyl butoxide: Data Evaluation Records (DERs) for EDSP Tier 1 Assays Docket Number: EPA-HQ-OPP-2010-0498. Available at: http://www.regulations.gov/contentStreamer?documentId=EPA-HQ-OPP-2010-0498-0019&disposition=attachment&contentType=pdf; TITLE=Piperonyl butoxide: Data Evaluation Records (DERs) for EDSP Tier 1 Assays Docket Number: EPA-HQ-OPP-2010-0498; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=inactive|Negative|Negative|anti-androgenic|see note; STUDY_GROUP=Uterotrophic Hershberger DB:15714284:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a4375fd860f3773193be1d052ca88bd7 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | LWK91TU9AH | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C19H30O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LWK91TU9AH"} |
| openFDA substances | FDA UNII substance identifier | LWK91TU9AH | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C19H30O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LWK91TU9AH"} |
| openFDA substances | FDA UNII substance identifier | LWK91TU9AH | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C19H30O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LWK91TU9AH"} |
| openFDA substances | FDA UNII substance identifier | LWK91TU9AH | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C19H30O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LWK91TU9AH"} |