Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Poloxamer 217. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 25000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 30000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 480 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 40 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
Expert Verdict
Residual EO/PO/1,4-dioxane impurities may warrant monitoring in sensitive formulations.
Regulatory Flags
Frequently Asked Questions
Is Poloxamer 217 safe in cosmetics?
Residual EO/PO/1,4-dioxane impurities may warrant monitoring in sensitive formulations. The EU classifies Poloxamer 217 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Poloxamer 217 allowed in the EU?
Poloxamer 217 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Poloxamer 217 do in cosmetics?
Poloxamer 217 functions as: Surfactant, emulsifying agent, cleansing agent, solubilizing agent. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6.
What is the Margin of Safety for Poloxamer 217?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Poloxamer 217?
The NOAEL (No Observed Adverse Effect Level) for Poloxamer 217 is 25000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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