Good Cosmetic Ingredient NOAEL Data

Polyglyceryl-10 Polyricinoleate

INCI: POLYGLYCERYL-10 POLYRICINOLEATE

CAS Number
29894-35-7
Function
Surfactant – emulsifying; viscosity controlling
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA permitted in cosmetics; polyglyceryl esters also permitted as direct food additive (21 CFR 172.854)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

6 study endpoints found for Polyglyceryl-10 Polyricinoleate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 845 mg/kg bw/day oral rat oral REACH
NOAEL 167 2105 1992 rat inhalation REACH
NOAEL >=8000 mg/kg bw/day oral rat oral REACH
NOEL 50000 ppm oral rat oral REACH
LOAEL 5 other oral rat oral REACH
NOAEL 10000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Must be formulated to be non-irritating; also used as food additive E 476 with ADI 0–7.5 mg/kg bw

⚠️
Concern Level: Low

Frequently Asked Questions

Is Polyglyceryl-10 Polyricinoleate safe in cosmetics?

Must be formulated to be non-irritating; also used as food additive E 476 with ADI 0–7.5 mg/kg bw The EU classifies Polyglyceryl-10 Polyricinoleate as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.

Is Polyglyceryl-10 Polyricinoleate allowed in the EU?

Polyglyceryl-10 Polyricinoleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyglyceryl-10 Polyricinoleate do in cosmetics?

Polyglyceryl-10 Polyricinoleate functions as: Surfactant – emulsifying; viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 29894-35-7.

What is the Margin of Safety for Polyglyceryl-10 Polyricinoleate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Polyglyceryl-10 Polyricinoleate?

The NOAEL (No Observed Adverse Effect Level) for Polyglyceryl-10 Polyricinoleate is 845 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.

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