Good Cosmetic Ingredient

Polygonum Cuspidatum Root Extract

INCI: POLYGONUM CUSPIDATUM ROOT EXTRACT

CAS Number
Not assigned
Function
Antioxidant, skin conditioning, anti-inflammatory, melanogenesis inhibition, photoprotection, anti-aging
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes On 2024 CIR Final Priority List (245 formulations). CIR report not yet published - formal safety conclusion pending. No FDA-mandated concentration limit or OTC restriction. MoCRA standard product listing obligations apply. When CIR report publishes, any concentration limits may apply retroactively.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Permitted in EU (EC 1223/2009, no Annex II/III listing); on 2024 CIR Priority List in US with safety assessment pending; limited dermal absorption with resveratrol concentrating in stratum corneum; non-sensitizing based on animal and clinical data.

⚠️
Concern Level: Low

Regulatory Flags

cir-review-pending no-sccs-opinion no-mos-calculated absorption-data-gap extract-standardization-variable clastogenic-in-vitro-negative-in-vivo

Frequently Asked Questions

Is Polygonum Cuspidatum Root Extract safe in cosmetics?

Permitted in EU (EC 1223/2009, no Annex II/III listing); on 2024 CIR Priority List in US with safety assessment pending; limited dermal absorption with resveratrol concentrating in stratum corneum; non-sensitizing based on animal and clinical data. The EU classifies Polygonum Cuspidatum Root Extract as "permitted". Safety rating: GOOD.

Is Polygonum Cuspidatum Root Extract allowed in the EU?

Polygonum Cuspidatum Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polygonum Cuspidatum Root Extract do in cosmetics?

Polygonum Cuspidatum Root Extract functions as: Antioxidant, skin conditioning, anti-inflammatory, melanogenesis inhibition, photoprotection, anti-aging. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Polygonum Cuspidatum Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Polygonum Cuspidatum Root Extract compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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