Polyquaternium-1

INCI: POLYQUATERNIUM-1

CAS Number
75345-27-6
Function
Antimicrobial, hair conditioning, film forming, antistatic
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific cosmetic restriction; widely used in ophthalmic solutions (Polyquad).

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

EU regulatory caution: Has inherent antimicrobial activity but is not on Annex V. If used in EU, must be claimed and justified for a function other than preservation (conditioning, film forming). If it contributes to preservation, document carefully to avoid regulatory challenge.

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Concern Level: Low

Regulatory Flags

preservative

Frequently Asked Questions

Is Polyquaternium-1 safe in cosmetics?

EU regulatory caution: Has inherent antimicrobial activity but is not on Annex V. If used in EU, must be claimed and justified for a function other than preservation (conditioning, film forming). If it contributes to preservation, document carefully to avoid regulatory challenge. The EU classifies Polyquaternium-1 as "permitted". Safety rating: GOOD.

Is Polyquaternium-1 allowed in the EU?

Polyquaternium-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyquaternium-1 do in cosmetics?

Polyquaternium-1 functions as: Antimicrobial, hair conditioning, film forming, antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 75345-27-6.

What is the Margin of Safety for Polyquaternium-1?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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