Poor Cosmetic Ingredient

Cinnamoylhydroxamic Acid

INCI: CINNAMOYLHYDROXAMIC ACID

CAS Number
6282-23-7 (trans-cinnamoylhydroxamic acid)
Function
Chelating agent; preservative booster (hydroxamic acid class)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not reviewed by CIR directly. Caprylhydroxamic Acid (related) was assessed and found safe with caution against use on damaged skin. Read-across possible but not guaranteed.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Dual structural alerts: cinnamoyl group (Michael acceptor) and hydroxamic acid (metal chelator, potential sensitizer on compromised skin). Must not be used with penetration enhancers per Caprylhydroxamic Acid CIR precedent. Full toxicological dossier required. Not CPSR-ready.

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Concern Level: High

Regulatory Flags

potential-allergen preservative

Frequently Asked Questions

Is Cinnamoylhydroxamic Acid safe in cosmetics?

Dual structural alerts: cinnamoyl group (Michael acceptor) and hydroxamic acid (metal chelator, potential sensitizer on compromised skin). Must not be used with penetration enhancers per Caprylhydroxamic Acid CIR precedent. Full toxicological dossier required. Not CPSR-ready. The EU classifies Cinnamoylhydroxamic Acid as "permitted". Safety rating: POOR.

Is Cinnamoylhydroxamic Acid allowed in the EU?

Cinnamoylhydroxamic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cinnamoylhydroxamic Acid do in cosmetics?

Cinnamoylhydroxamic Acid functions as: Chelating agent; preservative booster (hydroxamic acid class). It is classified as a cosmetic ingredient in our database. CAS number: 6282-23-7 (trans-cinnamoylhydroxamic acid).

What is the Margin of Safety for Cinnamoylhydroxamic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Cinnamoylhydroxamic Acid compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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