Polyurethane-33

INCI: POLYURETHANE-33

CAS Number
Not individually assigned; PubChem has a reference entry (SID505863099) but no discrete CID
Function
Binding agent that ensures cohesion of powdered products; film former
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; reported in VCRP; used at up to 7.5% in skin care (highest leave-on dermal concentration of any PU in this class); also used in spray products and around the eye

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Contains SMDI (saturated MDI analog) monomer with MDA concern addressed (no residual MDA detected in MDI production). Used in spray products with potential inhalation exposure, though 95-99% of spray particles are >10 µm (not respirable). No individual genotoxicity or sensitization data available.

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Polyurethane-33 safe in cosmetics?

Contains SMDI (saturated MDI analog) monomer with MDA concern addressed (no residual MDA detected in MDI production). Used in spray products with potential inhalation exposure, though 95-99% of spray particles are >10 µm (not respirable). No individual genotoxicity or sensitization data available. The EU classifies Polyurethane-33 as "permitted". Safety rating: GOOD.

Is Polyurethane-33 allowed in the EU?

Polyurethane-33 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyurethane-33 do in cosmetics?

Polyurethane-33 functions as: Binding agent that ensures cohesion of powdered products; film former. It is classified as a cosmetic ingredient in our database. CAS number: Not individually assigned; PubChem has a reference entry (SID505863099) but no discrete CID.

What is the Margin of Safety for Polyurethane-33?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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