NOAEL Studies
Cosmetic Ingredient
Potassium Iodide NOAEL Studies
INCI: POTASSIUM IODIDE
CAS: 7681-11-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 25 | mg/kg bw/day | rat | oral | 98 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 6 | mg/kg bw/day | syrian hamster | oral | 960 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 7.5 | mg/kg bw/day | rabbit | oral | NA | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 41 | mg/kg bw/day | swine | oral | 30 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 42 | mg/kg bw/day | rat | oral | 147 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 3 | mg/kg bw/day | mink | oral | 357 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 26 | mg/kg bw/day | rat | oral | 42 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =0.5 | mg/kg bw/day | American mink | - | - | reproduction toxicity | EFSA - 2013 - OutputID 2359 - reproduction - reproductive - Conclusion on the peer review of the pesticide risk assessment of the active substance potassium iodide. - doi:10.2903/j.efsa.2013.2923 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =0.5 | mg/kg bw/day | American mink | - | - | reproduction toxicity | EFSA - 2013 - OutputID 2359 - reproduction - reproductive - Conclusion on the peer review of the pesticide risk assessment of the active substance potassium iodide. - doi:10.2903/j.efsa.2013.2923 |
ToxValDB_ECHA_IUCLID 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOEL | <2.23 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b44b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15294/7/8?documentUUID=9fc0ea78-8834-461f-84d8-ef1bcaeb4724; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=thyroid gland: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15816093:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02775a10918ad2dc8178e26c3bde3380 |
| ToxValDB_ECHA_IUCLID | NOEL | =20 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1bee31; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15294/7/9/3?documentUUID=9fc0ea78-8834-461f-84d8-ef1bcaeb4724; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15822666:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6966ec22c877e049a77be842ca1297a8 |
ToxValDB_ECOTOX 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =1000 | ppm | Rat | oral | subchronic; 58 days | reproduction developmental | LONG_REF=Food Chem. Toxicol.22(12): 963-970 Vorhees,C.V., R.E. Butcher, and R.L. Brunner Developmental Toxicity and Psychotoxicity of Potassium Iodide in Rats: A Case for the Inclusion of Behaviour in Toxicological Assessment 1984; TITLE=Developmental Toxicity and Psychotoxicity of Potassium Iodide in Rats: A Case for the Inclusion of Behaviour in Toxicological Assessment; AUTHOR=Vorhees,C.V., R.E. Butcher, and R.L. Brunner; DOI=10.1016/0278-6915(84)90145-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=83334; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594191_15594192:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=632569aafc76e6144590e70068cb9d0f |
| ToxValDB_ECOTOX | LOEL | =0.3 | mg | Dog | injection | short-term; 2 days | short-term | LONG_REF=Mol. Cell. Endocrinol.131(2): 195-203 Uyttersprot,N., N. Pelgrims, N. Carrasco, C. Gervy, C. Maenhaut, J.E. Dumont, and F. Miot Moderate Doses of Iodide In Vivo Inhibit Cell Proliferation and the Expression of Thyroperoxidase and Na+/I- Symporter mRNAs in Dog Thyroid 1997; TITLE=Moderate Doses of Iodide In Vivo Inhibit Cell Proliferation and the Expression of Thyroperoxidase and Na+/I- Symporter mRNAs in Dog Thyroid; AUTHOR=Uyttersprot,N., N. Pelgrims, N. Carrasco, C. Gervy, C. Maenhaut, J.E. Dumont, and F. Miot; DOI=10.1016/s0303-7207(97)00108-1; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=83318; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15604074:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=46fabe6ff641c489ece9bd8b91a2e2d0 |
| ToxValDB_ECOTOX | LOEL | =5.6 | mg/kg dry food | Dog | oral | subchronic; 45 days | subchronic | LONG_REF=Vet. J.161(1): 80-84 Castillo,V.A., J.C. Lalia, M. Junco, G. Sartorio, A. Marquez, M.S. Rodriguez, and M.A. Pisarev Changes in Thyroid Function in Puppies Fed a high Iodine Commercial Diet 2001; TITLE=Changes in Thyroid Function in Puppies Fed a high Iodine Commercial Diet; AUTHOR=Castillo,V.A., J.C. Lalia, M. Junco, G. Sartorio, A. Marquez, M.S. Rodriguez, and M.A. Pisarev; DOI=10.1053/tvjl.2000.0523; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=83277; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Biochemistry: General biochemical effect|Hormone(s): Free thyroxine index|Hormone(s): Thyrotropin|Hormone(s): Thyroxine; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15608929:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7fcd180dbc927fde8eeee0c3452376ef |
| ToxValDB_ECOTOX | NOEL | =500 | ppm | Rat | oral | subchronic; 58 days | reproduction developmental | LONG_REF=Food Chem. Toxicol.22(12): 963-970 Vorhees,C.V., R.E. Butcher, and R.L. Brunner Developmental Toxicity and Psychotoxicity of Potassium Iodide in Rats: A Case for the Inclusion of Behaviour in Toxicological Assessment 1984; TITLE=Developmental Toxicity and Psychotoxicity of Potassium Iodide in Rats: A Case for the Inclusion of Behaviour in Toxicological Assessment; AUTHOR=Vorhees,C.V., R.E. Butcher, and R.L. Brunner; DOI=10.1016/0278-6915(84)90145-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=83334; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594191_15594192:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a277fe6eccd2f70dbb98d9f76f63ae8f |
| ToxValDB_ECOTOX | NOEL | =250 | ppm | Rat | oral | subchronic; 50 days | reproduction developmental | LONG_REF=Food Chem. Toxicol.22(12): 963-970 Vorhees,C.V., R.E. Butcher, and R.L. Brunner Developmental Toxicity and Psychotoxicity of Potassium Iodide in Rats: A Case for the Inclusion of Behaviour in Toxicological Assessment 1984; TITLE=Developmental Toxicity and Psychotoxicity of Potassium Iodide in Rats: A Case for the Inclusion of Behaviour in Toxicological Assessment; AUTHOR=Vorhees,C.V., R.E. Butcher, and R.L. Brunner; DOI=10.1016/0278-6915(84)90145-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=83334; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Behavior: Startle; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594663_15594664:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=21be3e34488128dbdd173dc9e7ebaabb |
ToxValDB_EFSA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | LEL | =5 | mg/kg bw/day | Chicken | oral | - | repeat dose other | LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of iodine compounds (E2) as feed additives for all species: calcium iodate anhydrous and potassium iodide, based on a dossier submitted by HELM AG. doi:10.2903/j.efsa.2013.3101.; TITLE=Scientific Opinion on the safety and efficacy of iodine compounds (E2) as feed additives for all species: calcium iodate anhydrous and potassium iodide, based on a dossier submitted by HELM AG; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3101; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15620838_15620841:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b243cf7b097a537d37a7609fd62e35bb |
| ToxValDB_EFSA | LEL | =8 | mg/kg bw/day | Pig | oral | - | repeat dose other | LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of iodine compounds (E2) as feed additives for all species: calcium iodate anhydrous and potassium iodide, based on a dossier submitted by HELM AG. doi:10.2903/j.efsa.2013.3101.; TITLE=Scientific Opinion on the safety and efficacy of iodine compounds (E2) as feed additives for all species: calcium iodate anhydrous and potassium iodide, based on a dossier submitted by HELM AG; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3101; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15620839_15620840:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64b3bd18a253ed4df8fa1f302741ce46 |
| ToxValDB_EFSA | NOAEL | =0.5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA (2013). Conclusion on the peer review of the pesticide risk assessment of the active substance potassium iodide. doi:10.2903/j.efsa.2013.2923.; TITLE=Conclusion on the peer review of the pesticide risk assessment of the active substance potassium iodide.; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2013.2923; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA:15620844:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e7411057f008cdbabde2f242f9ce4cb8 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.07 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634270_15634271:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc3c7d619f486832b410b3fa53cd9f3f |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.493 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634270_15634271:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_56fefa24240443d327a0564ce6377afb |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 1C4QK22F9J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"I.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1C4QK22F9J"} |
| openFDA substances | FDA UNII substance identifier | 1C4QK22F9J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"I.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1C4QK22F9J"} |
| openFDA substances | FDA UNII substance identifier | 1C4QK22F9J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"I.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1C4QK22F9J"} |
| openFDA substances | FDA UNII substance identifier | 1C4QK22F9J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"I.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1C4QK22F9J"} |