| ECHA |
LEL |
~115 |
mg/kg bw/day |
Rabbit |
oral |
- |
reproduction developmental |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823437_15823656:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b5d2d3169ccb93c2283f25922e494a8 |
| ECHA |
LEL |
=150 |
mg/kg bw/day |
Rabbit |
oral |
- |
developmental |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: changes in litter size and weights; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821858_15823521:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_90e3660f53b4a2908fbcdefc20efcd30 |
| ECHA |
LOAEL |
=50 |
mg/kg bw/day |
Rat |
dermal |
short-term; 4 weeks |
short-term |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f4ce4b096bca877d165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826817_15826818_15826819:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_523aacc80a2f537d380b9da5541e2b17 |
| ECHA |
LOAEL |
=250 |
mg/kg bw/day |
Rat |
dermal |
short-term; 4 weeks |
short-term |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f4ce4b096bca877d165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826817_15826818_15826819:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02aaa046a677f3d9c53c1ef5409ed977 |
| ECHA |
NOAEL |
=10 |
mg/kg bw/day |
Rat |
dermal |
- |
reproduction developmental |
QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95ee4b0a7c65d21cb4f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855570_15856368:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1adb3d7db50ab4da3d8425ff24632ac9 |
| ECHA |
NOAEL |
=30 |
mg/kg bw/day |
Rat |
dermal |
- |
reproduction developmental |
QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95ee4b0a7c65d21cb4f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855570_15856368:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fea337577fb52d1f22ff426adaf3a3ef |
| ECHA |
NOAEL |
=50 |
mg/kg bw/day |
Rabbit |
oral |
- |
reproduction developmental |
GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823437_15823656:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b0923999060be7caf744c4da5c09ad5a |
| ECHA |
NOAEL |
=80 |
mg/kg bw/day |
Rat |
dermal |
acute; 6 hours |
acute |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e09e4b096bca877812b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826380_15826381:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d4acec90466281313a5b2cab8f00350 |
| ECHA |
NOAEL |
=100 |
mg/kg bw/day |
Rat |
dermal |
short-term; 4 weeks |
short-term |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f4ce4b096bca877d165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826817_15826818_15826819:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7089d876d4eeff480676f991cba7895d |
| ECHA |
NOAEL |
=115 |
mg/kg bw/day |
Rabbit |
oral |
- |
developmental |
GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821858_15823521:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7b5c4bc62ff2e245290cb341976dec5e |
| ECHA |
NOAEL |
=150 |
mg/kg bw/day |
Rat |
oral |
short-term; 29 days |
short-term |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf51e4b0a7c65d1cd70e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=f613700f-1a0a-4dc1-bfd8-bc780e5738ef; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850926:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_61e3a7726e42132d88b38ffd59fd2182 |
| ECHA |
NOAEL |
>=250 |
mg/kg bw/day |
Rat |
dermal |
acute; 6 hours |
acute |
QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e09e4b096bca877812b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826380_15826381:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d311f2dec9da34624f68f7576d2afa38 |
| ECHA |
NOAEL |
=300 |
mg/kg bw/day |
Rat |
oral |
- |
reproduction developmental |
QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab87e4b0a7c65d1ba987; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=P0: reproductive function (oestrous cycle)|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855148_15855712_15855812_15856564_15863218:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b0b83f8dc44fd8389b804ceac528d05 |
| ECHA |
NOAEL |
=350 |
mg/kg bw/day |
Rat |
oral |
- |
developmental |
GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15825395:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4f7940fbcb58b9c6cf6d7322d44954b5 |
| ECHA |
NOAEL |
=450 |
mg/kg bw/day |
Rat |
oral |
- |
reproduction developmental |
QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab87e4b0a7c65d1ba983; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858421_15858680:-:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18db2abd4670458b429cd22b1fb8819d |
| ECHA |
NOAEL |
=600 |
mg/kg bw/day |
Rat |
oral |
- |
developmental |
QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab87e4b0a7c65d1ba987; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2120?documentUUID=294947b1-3cd2-4518-972f-bf0498139007; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15862312:-:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a3957cea064b9a82a00f01c26fb3cdc2 |