NOAEL Studies Humectant

Propanediol NOAEL Studies

INCI: PROPANEDIOL

CAS: 504-63-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =15 mg/kg/day rat oral 28 days repeated dose toxicity 20; 5; 15, 150, p.26
CIR Safety Assessment NOAEL =23 mg/kg/day rat inhalation 4-month inhalation toxicity 20; 150; 15, p.30
CIR Safety Assessment NOAEL =50 mg/kg/day rat oral 28 days oral toxicity (5; 5; 12, p.25
CIR Safety Assessment NOAEL =100 mg/kg/day rat oral - developmental toxicity 414; 6; 15, p.31
CIR Safety Assessment NOAEL =150 mg/kg/day rat oral 90 days repeated dose toxicity 10; 15, 150; 90, p.27
CIR Safety Assessment NOAEL =200 mg/kg/day - oral 42 days repeated dose toxicity 13; 200, 400, 800; 42, p.25
CIR Safety Assessment NOAEL =400 mg/kg/day rat oral 92 days repeated dose toxicity 15; 10; 100, 400, p.26
CIR Safety Assessment NOAEL =500 mg/kg/day rat oral 28 days oral toxicity 2; (5; 5, p.25
CIR Safety Assessment NOAEL =600 mg/kg/day rat oral 14 days repeated dose toxicity 5; 0, 300, 600; 14, p.26
CIR Safety Assessment NOAEL =1000 mg/kg/day rat oral Subchronic repeated dose toxicity 9; 5; 0, 100, 250, 500, p.25
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =15000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_6800; row=14376; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Propanediol; preferred_name=1,3-Propanediol; dtxsid=DTXSID8041246; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8041246; source_file=acute_oral.xlsx
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =12 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634328:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c0b1dca90511a2ab893cccef225b769
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5965N8W85T UNII - - - chemical -