NOAEL Studies
Cosmetic Ingredient
Propyl Gallate NOAEL Studies
INCI: PROPYL GALLATE
CAS: 121-79-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 2.925 | mg/kg bw/day | dog | oral | 420 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 4.68 | mg/kg bw/day | guinea pig | oral | 450 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 75 | mg/kg bw/day | mouse | oral | 56 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | hamster | oral | 5 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | rat | oral | 721 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 42 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 585 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 900 | mg/kg bw/day | mouse | oral | 721 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1250 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1500 | mg/kg bw/day | mouse | oral | 630 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1875 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2000 | mg/kg bw/day | rat | oral | 9 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3750 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5000 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =135 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA ANS - 2014 - OutputID 2487 - haematology - hemopoietic - Scientific Opinion on the re-evaluation of propyl gallate (E 310) as a food additive - doi:10.2903/j.efsa.2014.3642 |
| EFSA | NOAEL | =1910 | mg/kg bw/day | Rat | oral: feed | 91 days | subchronic | EFSA FEEDAP - 2020 - OutputID 3567 - clinical chemistry - systemic - Safety and efficacy of propyl gallate for all animal species - doi:10.2903/j.efsa.2020.6069 |
| EFSA | ADI | =0.5 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2014 - OutputID 2487 - Consumers - Scientific Opinion on the re-evaluation of propyl gallate (E 310) as a food additive - doi:10.2903/j.efsa.2014.3642 |
| EFSA | ADI | =0.5 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2014 - OutputID 2487 - Consumers - Scientific Opinion on the re-evaluation of propyl gallate (E 310) as a food additive - doi:10.2903/j.efsa.2014.3642 |
| EFSA | NOAEL | =1910 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=EFSA FEEDAP (2020). Safety and efficacy of propyl gallate for all animal species. doi:10.2903/j.efsa.2020.6069.; TITLE=Safety and efficacy of propyl gallate for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2020.6069; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15622614:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_17ab13348b84907aaa29c7bf55e1b7aa |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 49.7 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1960; Record_ID=adme_parameters_1058; Data_Type=Measured; DTXSID=DTXSID5021201; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=49.7; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE adme parameters | Fu | 0.0258 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1961; Record_ID=adme_parameters_1058; Data_Type=Measured; DTXSID=DTXSID5021201; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0258; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 12000 | ppm | Mouse | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=5643; Record_ID=cancer_6178; Data_Type=In Vivo; Formulation_Name=Propyl gallate; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=12000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Reference=TR-240; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr240/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 30.4262745677929 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9884; RecordID=ERPathway2016_268; DatasetName=ERPathway2016; DTXSID=DTXSID5021201; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=30.4262745677929; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE endocrine | ACC | 18.456602161568 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9885; RecordID=ERPathway2016_268; DatasetName=ERPathway2016; DTXSID=DTXSID5021201; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=18.456602161568; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9880; RecordID=ARPathway2016_692; DatasetName=ARPathway2016; DTXSID=DTXSID5021201; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE endocrine | Model Score | 0.0601 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=9886; RecordID=ERPathway2016_268; DatasetName=ERPathway2016; DTXSID=DTXSID5021201; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0601; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
NTP ICE skin sensitization 35 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 0.69 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3177; Record_ID=skin_sensitization_invitro_737; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=0.69; Reported_Response_Unit=ug/mL; Response=0.69; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD54, EC200 | 10 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3134; Record_ID=skin_sensitization_invitro_729; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=10; Reported_Response_Unit=ug/mL; Response=10; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD54, EC200 | 20.19 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3144; Record_ID=skin_sensitization_invitro_731; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=20.187999999999899; Reported_Response_Unit=ug/mL; Response=20.19; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD54, EC200 | 23.77 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3168; Record_ID=skin_sensitization_invitro_736; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=23.77; Reported_Response_Unit=ug/mL; Response=23.77; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD54, EC200 | 26.369 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3154; Record_ID=skin_sensitization_invitro_733; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=26.369; Reported_Response_Unit=ug/mL; Response=26.369; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD54, EC200 | 29.29 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3162; Record_ID=skin_sensitization_invitro_735; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=29.29; Reported_Response_Unit=ug/mL; Response=29.29; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD54, EC200 | 32.4 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1945; Record_ID=skin_sensitization_invitro_493; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=32.4; Reported_Response_Unit=ug/mL; Response=32.4; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD54, EC200 | 32.5 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3124; Record_ID=skin_sensitization_invitro_727; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=32.5; Reported_Response_Unit=ug/mL; Response=32.5; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD86, EC120 | 1.74 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; mMUSST | sheet=Data_invitro; excel_row=7795; Record_ID=skin_sensitization_invitro_1893; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=mMUSST; Endpoint=CD86, EC120; Reported_Response=8.2; Reported_Response_Unit=uM; Conversion_Factor_Value=212.201; Conversion_Factor_Source=EPA Dashboard; Converted_Response=1.74; Converted_Response_Unit=ug/mL; Response=1.74; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD86, EC150 | 1.889 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8320; Record_ID=skin_sensitization_invitro_2307; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=8.9; Reported_Response_Unit=uM; Conversion_Factor_Value=212.201; Conversion_Factor_Source=EPA Dashboard; Converted_Response=1.889; Converted_Response_Unit=ug/mL; Response=1.889; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CD86, EC150 | 1.97 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8500; Record_ID=skin_sensitization_invitro_2342; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=1.97; Reported_Response_Unit=ug/mL; Response=1.97; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CV70 | 32.75 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8501; Record_ID=skin_sensitization_invitro_2342; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=U-SENS; Endpoint=CV70; Reported_Response=32.75; Reported_Response_Unit=ug/mL; Response=32.75; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CV75 | 14.8 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3135; Record_ID=skin_sensitization_invitro_729; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CV75; Reported_Response=14.8; Reported_Response_Unit=ug/mL; Response=14.8; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | CV75 | 125 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1947; Record_ID=skin_sensitization_invitro_493; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=h-CLAT; Endpoint=CV75; Reported_Response=125; Reported_Response_Unit=ug/mL; Response=125; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Cys | 24.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1018; Record_ID=skin_sensitization_invitro_278; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=24.8; Reported_Response_Unit=%; Response=24.8; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Cys | 59.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1010; Record_ID=skin_sensitization_invitro_276; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=59.2; Reported_Response_Unit=%; Response=59.2; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Cys | 59.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1014; Record_ID=skin_sensitization_invitro_277; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=59.9; Reported_Response_Unit=%; Response=59.9; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Lys | -303 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1017; Record_ID=skin_sensitization_invitro_278; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-303; Reported_Response_Unit=%; Response=-303; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Lys | 26.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1013; Record_ID=skin_sensitization_invitro_277; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=26.6; Reported_Response_Unit=%; Response=26.6; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Lys | 63.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1009; Record_ID=skin_sensitization_invitro_276; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=63.6; Reported_Response_Unit=%; Response=63.6; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 12 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1019; Record_ID=skin_sensitization_invitro_278; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=12; Reported_Response_Unit=%; Response=12; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 43.25 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1015; Record_ID=skin_sensitization_invitro_277; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=43.25; Reported_Response_Unit=%; Response=43.25; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 61.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1011; Record_ID=skin_sensitization_invitro_276; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=61.4; Reported_Response_Unit=%; Response=61.4; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | EC1.5 | 132.8 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4944; Record_ID=skin_sensitization_invitro_1143; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=132.83699999999999; Reported_Response_Unit=uM; Response=132.8; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | EC1.5 | >140 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7611; Record_ID=skin_sensitization_invitro_1853; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=140; Reported_Response_Unit=uM; Response=140; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | EC1.5 | 191 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4946; Record_ID=skin_sensitization_invitro_1145; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=191; Reported_Response_Unit=uM; Response=191; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | EC1.5 | 199.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4948; Record_ID=skin_sensitization_invitro_1144; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=199.8; Reported_Response_Unit=uM; Response=199.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | EC3 | 202.727 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4950; Record_ID=skin_sensitization_invitro_1143; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=202.727; Reported_Response_Unit=uM; Response=202.727; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | IC50 | 605 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4951; Record_ID=skin_sensitization_invitro_1143; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=605; Reported_Response_Unit=uM; Response=605; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | IC50 | 650.3 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4952; Record_ID=skin_sensitization_invitro_1144; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=650.29999999999995; Reported_Response_Unit=uM; Response=650.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | IC50 | 731.5 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4954; Record_ID=skin_sensitization_invitro_1145; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=731.5; Reported_Response_Unit=uM; Response=731.5; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Imax | 0.8886 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7730; Record_ID=skin_sensitization_invitro_1853; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=LuSens; Endpoint=Imax; Reported_Response=0.888575576; Reported_Response_Unit=Unitless; Response=0.8886; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Imax | 8.2 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4956; Record_ID=skin_sensitization_invitro_1144; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=8.1999999999999993; Reported_Response_Unit=Unitless; Response=8.2; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Imax | 8.68 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4958; Record_ID=skin_sensitization_invitro_1145; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=8.68; Reported_Response_Unit=Unitless; Response=8.68; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
| NTP ICE skin sensitization | Imax | 9.24 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4959; Record_ID=skin_sensitization_invitro_1143; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021201; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.24; Reported_Response_Unit=Unitless; Response=9.24; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021201; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021201 |
EPA ToxRefDB v3 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =300 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=5627; toxval_study_source_id=studyid5627_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-eye-cataract|pathology microscopic-eye-retinopathy|pathology microscopic-kidney-nephropathy|in life observation-body weight-body weight; dose_level=1; study_year=1982; study_citation=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Chronic_Rats; dsstox_substance_id=DTXSID5021201; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =900 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5628; toxval_study_source_id=studyid5628_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1982; study_citation=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Chronic_Mice; dsstox_substance_id=DTXSID5021201; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5620; toxval_study_source_id=studyid5620_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-ulcer|in life observation-clinical signs-skin discoloration|pathology gross-intestine small-discolored|pathology microscopic-stomach-inflammation|pathology gross-stomach-thickened|pathology microscopic-stomach-necrosis|in life observation-body weight-body weight gain; dose_level=5; study_year=1982; study_citation=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; dsstox_substance_id=DTXSID5021201; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=5627; toxval_study_source_id=studyid5627_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-eye-cataract|pathology microscopic-eye-retinopathy|pathology microscopic-kidney-nephropathy|in life observation-body weight-body weight; dose_level=0; study_year=1982; study_citation=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Chronic_Rats; dsstox_substance_id=DTXSID5021201; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =300 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5620; toxval_study_source_id=studyid5620_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-ulcer|in life observation-clinical signs-skin discoloration|pathology microscopic-stomach-necrosis|pathology gross-intestine small-discolored|pathology gross-stomach-thickened; dose_level=3; study_year=1982; study_citation=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; dsstox_substance_id=DTXSID5021201; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =625 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5620; toxval_study_source_id=studyid5620_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-inflammation|pathology gross-intestine small-discolored|in life observation-clinical signs-skin discoloration|pathology microscopic-stomach-ulcer|in life observation-body weight-body weight gain|pathology microscopic-stomach-necrosis|pathology gross-stomach-thickened; dose_level=4; study_year=1982; study_citation=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; dsstox_substance_id=DTXSID5021201; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ECHA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =1152 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c2438; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=clinical signs|gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|gross pathology; STUDY_GROUP=ECHA IUCLID:15850548:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3096575d0f2bd5baa1dbe02c893863b1 |
| ECHA | LEL | =2462.5 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21d7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850542:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e9ad66edda36a5d7e047e2a9d7399e24 |
| ECHA | LEL | =12500 | ppm | Mouse | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca41e4b0a7c65d220fdb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID:15846191:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9aaa4ad783b2094f22db001c1131c869 |
| ECHA | LEL | =25000 | ppm | Rat | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca41e4b0a7c65d220fbe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID:15831253:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_492903acb4399ca3fe2e2666e00943ab |
| ECHA | LOAEL | =298 | mg/kg bw/day | Rat | oral | chronic; 721 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c2435; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15850546:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6a9033b54f68fd390cbd6e9bba9f1d37 |
| ECHA | LOAEL | =332 | mg/kg bw/day | Rat | oral | chronic; 721 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c2435; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15850547:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ab6802bcad7bb20c33ae39484fc84c44 |
| ECHA | LOAEL | =468 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162f6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/8?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID:15816316:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8921f15627a54d7247db42a30f47213e |
| ECHA | LOAEL | =1141 | mg/kg bw/day | Mouse | oral | chronic; 721 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c2430; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15850543:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_52e7b78d68c0fa24a903c5ca5abcbb69 |
| ECHA | LOAEL | =1591 | mg/kg bw/day | Mouse | oral | chronic; 721 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c2430; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15850544:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6cea96a80d15e827ec63bfa06c367153 |
| ECHA | LOAEL | =2220 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d216300; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/8?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID:15818427:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ffde3e2708ab63a1f969b40aff1e342 |
| ECHA | NOAEL | =135 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c2432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/6/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=blood: haematology; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID:15850545:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bbdc7ebbf3721eeb1b82e1abdcc3250f |
| ECHA | NOAEL | =250 | mg/kg bw/day | Hamster | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f44c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/9/3?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15821916:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1545fba00b227b620558fa9c1f906f94 |
| ECHA | NOAEL | =260 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5e46; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/9/2?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15862587:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_658952a23ecb321a3b9c87b0538fff81 |
| ECHA | NOAEL | =880 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbbba; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24203/7/9/3?documentUUID=8e00c401-75a8-4d55-8e9a-1e207d5fdfec; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15824123:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5099709e1e5f18ddb513ca5da056e78d |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =2000 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15596960:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d6407bbaf8f6e38cc92e4dc3f6949400 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =6.66 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634408:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_725a296a3ea1a8f93ba8b06ceaef3885 |
ToxValDB ToxRefDB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =300 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Chronic_Rats; TITLE=Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5627; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-eye-cataract|systemic: pathology microscopic-eye-retinopathy|systemic: pathology microscopic-kidney-nephropathy|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709726_15709727:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_75176ea9ed831b3555bd2beb92e5e02b |
| ToxValDB ToxRefDB | LEL | =900 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Chronic_Mice; TITLE=Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5628; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15709730_15709731:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0db26d611405948ad8b52368d260709c |
| ToxValDB ToxRefDB | LEL | =1250 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; TITLE=Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5620; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: pathology gross-intestine small-discolored|systemic: pathology gross-stomach-thickened|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-stomach-necrosis|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-stomach-inflammation|systemic: in life observation-clinical signs-skin discoloration; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709702_15709703:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3738fcd0e9c1fe46f32e2603849b286 |
| ToxValDB ToxRefDB | NEL | =300 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; TITLE=Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5620; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-skin discoloration|systemic: pathology gross-intestine small-discolored|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-stomach-thickened|systemic: pathology microscopic-stomach-necrosis|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709704_15709705_15709706_15709707:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0fd65f02f1fabf356d9ab9550814f4b |
| ToxValDB ToxRefDB | NEL | =625 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1982_Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; TITLE=Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5620; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-skin discoloration|systemic: pathology microscopic-stomach-inflammation|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-stomach-necrosis|systemic: pathology microscopic-stomach-ulcer|systemic: pathology gross-stomach-thickened|systemic: pathology gross-intestine small-discolored; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709702_15709703:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ae1d4806a42b94182bb36d17dc70203 |
WHO/JECFA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | <=1.4 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0374e4b0d99f5a887e40; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1272; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=WHO JECFA ADI:15715691:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c406c455e9edb5586d390f7ae69b6d38 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8D4SNN7V92 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H12O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8D4SNN7V92"} |
| openFDA substances | FDA UNII substance identifier | 8D4SNN7V92 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H12O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8D4SNN7V92"} |
| openFDA substances | FDA UNII substance identifier | 8D4SNN7V92 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H12O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8D4SNN7V92"} |
| openFDA substances | FDA UNII substance identifier | 8D4SNN7V92 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H12O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8D4SNN7V92"} |