Is Propylene Glycol Dicaproate safe in cosmetics?
Propylene Glycol Dicaproate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
Propylene Glycol Dicaproate
INCI: PROPYLENE GLYCOL DICAPROATE
Propylene Glycol Dicaproate (CAS 50343-36-7) is a cosmetic cosmetic ingredient functioning as Skin-conditioning agent (occlusive); Viscosity increasing agent (nonaqueous). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
View industrial chemical safety profile for CAS 50343-36-7 →
Function
Skin-conditioning agent (occlusive); Viscosity increasing agent (nonaqueous)
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-hexanoyloxypropyl hexanoate
InChIKey
RMZFJNNOMUICLE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR concluded "safe as used" when formulated to be nonirritating (2014); PG mono/diesters permitted as food additives (21 CFR 172.856)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propylene Glycol Dicaproate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1984
Source: WHO/JECFA
JECFA Evaluation
PROPYLENEGLYCOL DIHEXANOATE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/71
Source: WHO/JECFA
Editorial summary
Preliminary editorial summary for Propylene Glycol Dicaproate — not a computed safety verdict. See the sourced toxicological data above.
Chemical Function
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
food_additive
Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2268845
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
PROPYLENEGLYCOL DIHEXANOATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Propylene Glycol Dicaproate allowed in the EU?
Propylene Glycol Dicaproate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Propylene Glycol Dicaproate do in cosmetics?
Propylene Glycol Dicaproate functions as: Skin-conditioning agent (occlusive); Viscosity increasing agent (nonaqueous). It is classified as a cosmetic ingredient in our database. CAS number: 50343-36-7.
Is Propylene Glycol Dicaproate used outside cosmetics?
Propylene Glycol Dicaproate also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Propylene Glycol Dicaproate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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