Propylene Glycol Dicaproate

INCI: PROPYLENE GLYCOL DICAPROATE

CAS Number
50343-36-7
Function
Skin-conditioning agent (occlusive); Viscosity increasing agent (nonaqueous)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR concluded "safe as used" when formulated to be nonirritating (2014); PG mono/diesters permitted as food additives (21 CFR 172.856)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

⚠ Limited direct tox data — safety is inferred from group read-across, not direct testing. ⚠ If formulating, penetration enhancement potential applies to all PG diesters. ⚠ cGMP batch purity controls recommended

⚠️
Concern Level: Low

Frequently Asked Questions

Is Propylene Glycol Dicaproate safe in cosmetics?

⚠ Limited direct tox data — safety is inferred from group read-across, not direct testing. ⚠ If formulating, penetration enhancement potential applies to all PG diesters. ⚠ cGMP batch purity controls recommended The EU classifies Propylene Glycol Dicaproate as "permitted". Safety rating: GOOD.

Is Propylene Glycol Dicaproate allowed in the EU?

Propylene Glycol Dicaproate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propylene Glycol Dicaproate do in cosmetics?

Propylene Glycol Dicaproate functions as: Skin-conditioning agent (occlusive); Viscosity increasing agent (nonaqueous). It is classified as a cosmetic ingredient in our database. CAS number: 50343-36-7.

What is the Margin of Safety for Propylene Glycol Dicaproate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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