Moderate Cosmetic Ingredient NOAEL Data Sensitization Data

PROPYLIDENE PHTHALIDE

CAS Number
17369-59-4
Function
Perfuming
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Restricted
EU Max Conc. III/175
๐Ÿ‡บ๐Ÿ‡ธ US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

2 study endpoints found for PROPYLIDENE PHTHALIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 6.55 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 6.55 mg/kg bw/day oral rat Subchronic COSMOS_DB

Sensitization Profile

Contact sensitization data for PROPYLIDENE PHTHALIDE based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS/1459/11

Expert Verdict

PROPYLIDENE PHTHALIDE is listed in the EU CosIng database with functions: Perfuming It is restricted under EU Cosmetics Regulation. Restriction: III/175.

โš ๏ธ
Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted fragrance needs-enrichment ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is PROPYLIDENE PHTHALIDE safe in cosmetics?

PROPYLIDENE PHTHALIDE is listed in the EU CosIng database with functions: Perfuming It is restricted under EU Cosmetics Regulation. Restriction: III/175. The EU classifies PROPYLIDENE PHTHALIDE as "Restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is PROPYLIDENE PHTHALIDE allowed in the EU?

PROPYLIDENE PHTHALIDE EU regulatory status: Restricted. Maximum allowed concentration: III/175. This is based on EU Regulation 1223/2009 and its amendments.

What does PROPYLIDENE PHTHALIDE do in cosmetics?

PROPYLIDENE PHTHALIDE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 17369-59-4.

What is the NOAEL for PROPYLIDENE PHTHALIDE?

The NOAEL (No Observed Adverse Effect Level) for PROPYLIDENE PHTHALIDE is 6.55 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

๐Ÿ“ฑ

Is PROPYLIDENE PHTHALIDE in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for PROPYLIDENE PHTHALIDE in your formulation.