Is Protocatechuicaldehyde safe in cosmetics?
Protocatechuicaldehyde has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Protocatechuicaldehyde
Also known as: Benzaldehyde, 3,4-dihydroxy-, EINECS 205-377-7, UNII-4PVP2HCH4T, protocatechuic aldehyde
INCI: PROTOCATECHUICALDEHYDE
Protocatechuicaldehyde (CAS 139-85-5) is a cosmetic cosmetic ingredient functioning as Bleaching, antioxidant, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 139-85-5 →
Auto-generated CPSR Part A draft with source citations
Function
Bleaching, antioxidant, skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3,4-dihydroxybenzaldehyde
InChIKey
IBGBGRVKPALMCQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted; FDA UNII: 4PVP2HCH4T
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Protocatechuicaldehyde.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Bleaching agent
Flavouring and nutrient
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Protocatechuicaldehyde.
Regulatory Flags
potential-allergen
Known Synonyms
Benzaldehyde, 3,4-dihydroxy-
EINECS 205-377-7
UNII-4PVP2HCH4T
protocatechuic aldehyde
Chemical Function
Antioxidant
Softener and conditioner
Bleaching agent
Flavouring and nutrient
Regulatory Lists
Raw materials
Europe
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PROTOCATECHUALDEHYDE
ChEMBL ID
CHEMBL222021
Frequently Asked Questions
Is Protocatechuicaldehyde allowed in the EU?
Protocatechuicaldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Protocatechuicaldehyde do in cosmetics?
Protocatechuicaldehyde functions as: Bleaching, antioxidant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 139-85-5.
Is Protocatechuicaldehyde used outside cosmetics?
Protocatechuicaldehyde also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Protocatechuicaldehyde compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
Calcium Cyclamate
Poor
Chemical family
Flavouring (oral care sweetener)
Citronellyl Phenylacetate
Excellent
Chemical family
Fragrance / Perfuming agent
Disodium EDTA
Excellent
Chemical family
Chelating agent; metal ion sequestran...
Is Protocatechuicaldehyde in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Protocatechuicaldehyde in your formulation.