Puerarin

INCI: PUERARIN

CAS Number
3681-99-0
Function
Antioxidant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted by FDA; FDA UNII: Z9W8997416

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHS classifications include H315 (skin irritation) and H319 (serious eye irritation) for the pure substance; these apply at neat/concentrated handling levels, not typical cosmetic dilutions (≤0.5%). Estrogenic activity possible as an isoflavone—endocrine activity should be considered in safety assessment for leave-on products.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Puerarin safe in cosmetics?

GHS classifications include H315 (skin irritation) and H319 (serious eye irritation) for the pure substance; these apply at neat/concentrated handling levels, not typical cosmetic dilutions (≤0.5%). Estrogenic activity possible as an isoflavone—endocrine activity should be considered in safety assessment for leave-on products. The EU classifies Puerarin as "permitted". Safety rating: GOOD.

Is Puerarin allowed in the EU?

Puerarin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Puerarin do in cosmetics?

Puerarin functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 3681-99-0.

What is the Margin of Safety for Puerarin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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