Is Puerarin safe in cosmetics?
Puerarin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Puerarin
Also known as: Kakonein
INCI: PUERARIN
Puerarin (CAS 3681-99-0) is a cosmetic cosmetic ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3681-99-0 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
InChIKey
HKEAFJYKMMKDOR-VPRICQMDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA; FDA UNII: Z9W8997416
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Puerarin.
Calculate MoS for your specific formulation with the MoS Calculator.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ
LOEC: 1 nM
EU status: allowed
agonist
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Puerarin.
Known Synonyms
Kakonein
Chemical Function
Antioxidant
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PUERARIN
ChEMBL ID
CHEMBL486386
Max Phase
2
Frequently Asked Questions
Is Puerarin allowed in the EU?
Puerarin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Puerarin do in cosmetics?
Puerarin functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 3681-99-0.
Is Puerarin used outside cosmetics?
Puerarin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Puerarin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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