Is cis-3-Hexenyl Acetate safe in cosmetics?
cis-3-Hexenyl Acetate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
cis-3-Hexenyl Acetate
Also known as: z3HAC, 3-02-00-00287, BRN 1721854, EINECS 222-960-1, FEMA No. 3171 (+6 more)
INCI: CIS-3-HEXENYL ACETATE
cis-3-Hexenyl Acetate (CAS 3681-71-8) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with green, fresh-cut grass note. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3681-71-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with green, fresh-cut grass note
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[(Z)-hex-3-enyl] acetate
InChIKey
NPFVOOAXDOBMCE-PLNGDYQASA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR-reviewed and assessed as safe; FEMA GRAS; FDA-listed food substance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for cis-3-Hexenyl Acetate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6480 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
134
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
cis-3-HEXENYL ACETATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl Acetate.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
z3HAC
3-02-00-00287
BRN 1721854
EINECS 222-960-1
FEMA No. 3171
3-Hexenyl acetate, (Z)-
UNII-6INA6GC5I6
(3Z)-hex-3-en-1-yl acetate
(Z)-3-hexenol acetate
cis-3-hexen-1-yl acetate
cis-3-hexenyl ethanoate
Chemical Function
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
SCIL (9/2019)
air; detected; emissions; Personal care
inert_ingredient; non_food_use; Pesticides
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
(Z)-hex-3-en-1-yl acetate
ChEMBL ID
CHEMBL2251454
Frequently Asked Questions
Is cis-3-Hexenyl Acetate allowed in the EU?
cis-3-Hexenyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl Acetate do in cosmetics?
cis-3-Hexenyl Acetate functions as: Fragrance ingredient with green, fresh-cut grass note. It is classified as a cosmetic ingredient in our database. CAS number: 3681-71-8.
Is cis-3-Hexenyl Acetate used outside cosmetics?
cis-3-Hexenyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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3-Hexenyl Acetate
Moderate
Chemical family
Fragrance/Perfuming
Hexenyl Acetate
Good
Chemical family
Fragrance ingredient with green, frui...
Puerarin
Good
Chemical family
Antioxidant
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