Excellent Cosmetic Ingredient NOAEL Data

cis-3-Hexenyl Acetate

INCI: CIS-3-HEXENYL ACETATE

CAS Number
3681-71-8
Function
Fragrance ingredient with green, fresh-cut grass note
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR-reviewed and assessed as safe; FEMA GRAS; FDA-listed food substance

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for cis-3-Hexenyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Safe fragrance ingredient with low sensitization potential; IFRA sets maximum use levels by product category (0.077% in lip products, 0.46% in face/body leave-on products).

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Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is cis-3-Hexenyl Acetate safe in cosmetics?

Safe fragrance ingredient with low sensitization potential; IFRA sets maximum use levels by product category (0.077% in lip products, 0.46% in face/body leave-on products). The EU classifies cis-3-Hexenyl Acetate as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.

Is cis-3-Hexenyl Acetate allowed in the EU?

cis-3-Hexenyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does cis-3-Hexenyl Acetate do in cosmetics?

cis-3-Hexenyl Acetate functions as: Fragrance ingredient with green, fresh-cut grass note. It is classified as a cosmetic ingredient in our database. CAS number: 3681-71-8.

What is the Margin of Safety for cis-3-Hexenyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for cis-3-Hexenyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for cis-3-Hexenyl Acetate is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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