Is Pyridoxamine safe in cosmetics?
Pyridoxamine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Pyridoxamine
Also known as: EINECS 201-640-5, UNII-6466NM3W93, 2-Methyl-4-aminomethyl-5-hydroxymethyl-3-Pyridinol, 4-(Aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol, 4-(Aminomethyl)-5-hydroxy-6-methyl-3-Pyridinemethanol (+2 more)
INCI: PYRIDOXAMINE
Pyridoxamine (CAS 85-87-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent, antioxidant (advanced glycation end-product inhibitor). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 85-87-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent, antioxidant (advanced glycation end-product inhibitor)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol
InChIKey
NHZMQXZHNVQTQA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use. FDA regulatory action against pyridoxamine applies to unapproved drug forms in supplement form only, not to cosmetic topical use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pyridoxamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Pyridoxamine.
Known Synonyms
EINECS 201-640-5
UNII-6466NM3W93
2-Methyl-4-aminomethyl-5-hydroxymethyl-3-Pyridinol
4-(Aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol
4-(Aminomethyl)-5-hydroxy-6-methyl-3-Pyridinemethanol
4-(aminomethyl)-2-methyl-5-methylol-pyridin-3-ol
4-(aminomethyl)-5-(hydroxymethyl)-2-methyl-pyridin-3-ol
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PYRIDOXAMINE
ChEMBL ID
CHEMBL593019
Max Phase
2
Frequently Asked Questions
Is Pyridoxamine allowed in the EU?
Pyridoxamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pyridoxamine do in cosmetics?
Pyridoxamine functions as: Skin conditioning agent, antioxidant (advanced glycation end-product inhibitor). It is classified as a cosmetic ingredient in our database. CAS number: 85-87-0.
Is Pyridoxamine used outside cosmetics?
Pyridoxamine also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pyridoxamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ARCTIUM LAPPA/CARROT/COLOCASIA ESCULENTA/DIOSCOREA BATATAS/GARLIC/GINGER/IPOMOEA BATATAS/NELUMBO NUCIFERA/ONION/POTATO BULBS)/(CHESTNUT/CITRUS UNSHIU/EGGPLANT/FIG/GRAPE/KIWI/LYCOPERSICON ESCULENTUM/MALUS PUMILA/MUME/PEACH/PLUM/PUMPKIN/PYRUS SEROTINA/RADISH/ZIZIPHUS JUJUBA FRUIT)/(ALLIUM TUBEROSUM/ALOE BARBADENSIS/ANGELICA UTILIS/BRASSICA OLERACEA ACEPHALA/CABBAGE/CELERY/SACCHARINA JAPONICA/UNDARIA PINNATIFIDA LEAF)/(ALLIUM FISTULOSUM/ENTEROMORPHA COMPRESSA/OENANTHE JAVANICA STALK)/LENTINULA EDODES/SUCROSE FERMENT FILTRATE
Good
Similar safety
Humectant, Skin Conditioning - Humect...
(ASPERGILLUS/SACCHAROMYCES)/RICE FERMENT/BARLEY GRAIN MEAL/NELUMBO NUCIFERA FLOWER EXTRACT FERMENT EXTRACT FILTRATE
Good
Similar safety
Bleaching
(ASTRAGALUS MEMBRANACEUS/GLYCYRRHIZA URALENSIS (LICORICE)/PANAX GINSENG) ROOT/AMOMUM XANTHIOIDES SEED/HORDEUM VULGARE SPROUT/ARALIA CORDATA/ACHYRANTHES JAPONICA EXTRACT
Good
Similar safety
Skin Conditioning - Miscellaneous
Benzophenone-7
Moderate
Chemical family
UV absorber
Butyl Benzyl Phthalate
Poor
Chemical family
Plasticizer; historically used in nai...
Butyl Benzyl Phthalate (BBP)
Poor
Chemical family
Plasticizer, solvent (historically us...
Is Pyridoxamine in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Pyridoxamine in your formulation.