Pyridoxamine

INCI: PYRIDOXAMINE

CAS Number
85-87-0
Function
Skin conditioning agent, antioxidant (advanced glycation end-product inhibitor)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use. FDA regulatory action against pyridoxamine applies to unapproved drug forms in supplement form only, not to cosmetic topical use.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Anti-glycation properties provide anti-aging benefits, but limited independent dermal safety data exists compared to pyridoxine HCl; use levels should remain conservative at 0.5% or below pending further data.

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Concern Level: Moderate

Frequently Asked Questions

Is Pyridoxamine safe in cosmetics?

Anti-glycation properties provide anti-aging benefits, but limited independent dermal safety data exists compared to pyridoxine HCl; use levels should remain conservative at 0.5% or below pending further data. The EU classifies Pyridoxamine as "permitted". Safety rating: GOOD.

Is Pyridoxamine allowed in the EU?

Pyridoxamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pyridoxamine do in cosmetics?

Pyridoxamine functions as: Skin conditioning agent, antioxidant (advanced glycation end-product inhibitor). It is classified as a cosmetic ingredient in our database. CAS number: 85-87-0.

What is the Margin of Safety for Pyridoxamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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