Poor Cosmetic Ingredient NOAEL Data GHS Classified SCCS/CIR Reviewed

Butyl Benzyl Phthalate

INCI: BUTYL BENZYL PHTHALATE

CAS Number
85-68-7
Function
Plasticizer; historically used in nail polish; not a standard cosmetic ingredient
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Prohibited substance; no safe use level established for cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Butyl Benzyl Phthalate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL ca.780 mg/kg bw/day oral mouse oral REACH
NOAEL ca.300 mg/kg bw/day oral rat oral REACH
NOAEL ca.240 mg/kg bw/day oral rat oral REACH
NOAEL 1 other 1991 rat inhalation REACH
NOAEL 0.144 other 1991 rat inhalation REACH
NOAEL ca.151 mg/kg bw/day oral rat oral REACH
NOAEL 550 mg/kg bw/day oral rat oral REACH
NOAEL 0.218 other 1991 rat inhalation REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Long-term Exposure Effects
Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: unknown

Expert Verdict

CRITICAL โ€“ EU/ASEAN/China prohibited; CMR 1B classification; endocrine disruptor and reproductive toxicant. Must not appear in any cosmetic formulation or as a contaminant.

โš ๏ธ
Concern Level: High

Regulatory Flags

endocrine_disruptor prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Butyl Benzyl Phthalate safe in cosmetics?

CRITICAL โ€“ EU/ASEAN/China prohibited; CMR 1B classification; endocrine disruptor and reproductive toxicant. Must not appear in any cosmetic formulation or as a contaminant. The EU classifies Butyl Benzyl Phthalate as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is Butyl Benzyl Phthalate allowed in the EU?

Butyl Benzyl Phthalate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Butyl Benzyl Phthalate do in cosmetics?

Butyl Benzyl Phthalate functions as: Plasticizer; historically used in nail polish; not a standard cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 85-68-7.

What is the Margin of Safety for Butyl Benzyl Phthalate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Butyl Benzyl Phthalate?

The NOAEL (No Observed Adverse Effect Level) for Butyl Benzyl Phthalate is ca.780 mg/kg bw/day based on a oral study via oral route in mouse. A total of 10 study endpoints are available. Source: REACH.

๐Ÿ“ฑ

Is Butyl Benzyl Phthalate in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Butyl Benzyl Phthalate in your formulation.