Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Quaternium-81. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
None identified; standard quat class considerations apply
Frequently Asked Questions
Is Quaternium-81 safe in cosmetics?
None identified; standard quat class considerations apply The EU classifies Quaternium-81 as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Quaternium-81 allowed in the EU?
Quaternium-81 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quaternium-81 do in cosmetics?
Quaternium-81 functions as: Antistatic, Hair Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 97953-16-7.
What is the Margin of Safety for Quaternium-81?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Quaternium-81?
The NOAEL (No Observed Adverse Effect Level) for Quaternium-81 is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
Check Quaternium-81 compliance across multiple jurisdictions:
Related Ingredients
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