Quercetin Dihydrate

INCI: QUERCETIN

CAS Number
6151-25-3
Function
Antioxidant, skin conditioning, UV absorber, anti-inflammatory
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; quercetin has extensive GRAS history as a food flavonoid. No FDA cosmetic restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

In vitro mutagenicity positive in Ames test but in vivo studies consistently negative; EFSA and WHO/JECFA concluded no genotoxic concern in vivo. Photodegradable and may form pro-oxidant quinone metabolites at very high concentrations. Formulation stability requires attention due to oxidation sensitivity.

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Concern Level: Moderate

Frequently Asked Questions

Is Quercetin Dihydrate safe in cosmetics?

In vitro mutagenicity positive in Ames test but in vivo studies consistently negative; EFSA and WHO/JECFA concluded no genotoxic concern in vivo. Photodegradable and may form pro-oxidant quinone metabolites at very high concentrations. Formulation stability requires attention due to oxidation sensitivity. The EU classifies Quercetin Dihydrate as "permitted". Safety rating: GOOD.

Is Quercetin Dihydrate allowed in the EU?

Quercetin Dihydrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Quercetin Dihydrate do in cosmetics?

Quercetin Dihydrate functions as: Antioxidant, skin conditioning, UV absorber, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 6151-25-3.

What is the Margin of Safety for Quercetin Dihydrate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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