Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Quillaja Saponaria Bark. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 25 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2200 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 1180 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1175 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| dose_tested | 25 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Saponin-rich — can cause hemolysis if ingested in large amounts (not a topical concern at cosmetic levels); GRAS status supports general safety profile; widely used as natural surfactant/emulsifier alternative
Regulatory Flags
Frequently Asked Questions
Is Quillaja Saponaria Bark safe in cosmetics?
Saponin-rich — can cause hemolysis if ingested in large amounts (not a topical concern at cosmetic levels); GRAS status supports general safety profile; widely used as natural surfactant/emulsifier alternative The EU classifies Quillaja Saponaria Bark as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is Quillaja Saponaria Bark allowed in the EU?
Quillaja Saponaria Bark EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quillaja Saponaria Bark do in cosmetics?
Quillaja Saponaria Bark functions as: Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 68990-67-0.
What is the Margin of Safety for Quillaja Saponaria Bark?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Quillaja Saponaria Bark?
The NOAEL (No Observed Adverse Effect Level) for Quillaja Saponaria Bark is 25 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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