NOAEL Studies Cosmetic Ingredient

Quillaja Saponaria Bark NOAEL Studies

INCI: QUILLAJA SAPONARIA BARK

CAS: 68990-67-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 25 mg/kg bw/day rat oral 84 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1175 mg/kg bw/day rat oral 756 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1180 mg/kg bw/day rat oral 94 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2200 mg/kg bw/day mouse oral 588 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1500 mg/kg bw/day Rat oral: feed 730 days chronic/long term toxicity EFSA FAF - 2019 - OutputID 3221 - no adverse effect observed at single/highest dose - Re-evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use - doi:10.2903/j.efsa.2019.5622
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =3 mg/kg bw/day Consumers - - ADI EFSA FAF - 2019 - OutputID 3221 - Consumers - Re-evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use - doi:10.2903/j.efsa.2019.5622
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =3 mg/kg bw/day Consumers - - ADI EFSA FAF - 2019 - OutputID 3221 - Consumers - Re-evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use - doi:10.2903/j.efsa.2019.5622
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =1500 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=EFSA FAF (2019). Re-evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use. doi:10.2903/j.efsa.2019.5622.; TITLE=Re-evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use; AUTHOR=EFSA FAF; DOI=doi:10.2903/j.efsa.2019.5622; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2019; ORIGINAL_YEAR=2019; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625464:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_639a7b2dac6ac7ddda763a1d4a8ceec3
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}