r-Clostridium Histolyticum Collagenase H sh-Oligopeptide-60

INCI: R-CLOSTRIDIUM HISTOLYTICUM COLLAGENASE H SH-OLIGOPEPTIDE-60

CAS Number
Not assigned
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted; falls under general cosmetic ingredient provisions (no pre-market approval required)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Contains collagenase enzyme domain โ€” potential for ECM degradation if biologically active at use levels; No published maximum use concentration; Bacterial recombinant origin requires endotoxin control in manufacturing

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Concern Level: Moderate

Frequently Asked Questions

Is r-Clostridium Histolyticum Collagenase H sh-Oligopeptide-60 safe in cosmetics?

Contains collagenase enzyme domain โ€” potential for ECM degradation if biologically active at use levels; No published maximum use concentration; Bacterial recombinant origin requires endotoxin control in manufacturing The EU classifies r-Clostridium Histolyticum Collagenase H sh-Oligopeptide-60 as "permitted". Safety rating: MODERATE.

Is r-Clostridium Histolyticum Collagenase H sh-Oligopeptide-60 allowed in the EU?

r-Clostridium Histolyticum Collagenase H sh-Oligopeptide-60 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does r-Clostridium Histolyticum Collagenase H sh-Oligopeptide-60 do in cosmetics?

r-Clostridium Histolyticum Collagenase H sh-Oligopeptide-60 functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for r-Clostridium Histolyticum Collagenase H sh-Oligopeptide-60?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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