Good Cosmetic Ingredient

rh-Polypeptide-13

INCI: RH-POLYPEPTIDE-13 (ALSO KNOWN AS CG-NOGGIN; FORMER HUMAN OLIGOPEPTIDE-18 / RH-OLIGOPEPTIDE-18)

CAS Number
928858-36-0
Function
Hair growth stimulator; BMP4 antagonist — stimulates hair placode formation, enhances epidermal thickness, anti-hair loss, anti-depigmentation
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA UNII: 03Z015E4XN — registered but no specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Bioactive BMP4 antagonist — morphogenetic signaling pathway interference; theoretical developmental/proliferative concerns at supraphysiological doses; E. coli fermentation origin requires endotoxin control

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Concern Level: Low

Frequently Asked Questions

Is rh-Polypeptide-13 safe in cosmetics?

Bioactive BMP4 antagonist — morphogenetic signaling pathway interference; theoretical developmental/proliferative concerns at supraphysiological doses; E. coli fermentation origin requires endotoxin control The EU classifies rh-Polypeptide-13 as "permitted". Safety rating: GOOD.

Is rh-Polypeptide-13 allowed in the EU?

rh-Polypeptide-13 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does rh-Polypeptide-13 do in cosmetics?

rh-Polypeptide-13 functions as: Hair growth stimulator; BMP4 antagonist — stimulates hair placode formation, enhances epidermal thickness, anti-hair loss, anti-depigmentation. It is classified as a cosmetic ingredient in our database. CAS number: 928858-36-0.

What is the Margin of Safety for rh-Polypeptide-13?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check rh-Polypeptide-13 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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