NOAEL Studies Cosmetic Ingredient

Ricinus Communis Seed Oil NOAEL Studies

INCI: RICINUS COMMUNIS SEED OIL

CAS: 8001-79-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 3045 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7823 mg/kg bw/day mouse oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 12840 mg/kg bw/day rat oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 11329 mg/kg bw/day rat oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =5780 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf23e4b0a7c65d1cca2f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10783/7/6/2?documentUUID=8c8efa4a-2a2a-4430-9ddc-99059c204309; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15838578:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f8a9362d69c6d255b4b330a5d6330e9
ToxValDB_ECHA_IUCLID NOAEL =10000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8e39; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/14599?documentUUID=2f224799-939b-417d-a8f9-2e06b72fbc96; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: haematology|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: histopathology: non-neoplastic|P0: reproductive function (oestrous cycle)|P0: reproductive function (sperm measures); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15860849:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a23cb3ac63d0101a8fa31700e9dd9547
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=0.7 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb94e4b0d99f5a87b432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/96; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=WHO JECFA ADI:15715365:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_928a1cee071ed12937b7fe9036a620c8
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier D5340Y2I9G UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"D5340Y2I9G"}
openFDA substances FDA UNII substance identifier D5340Y2I9G UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"D5340Y2I9G"}
openFDA substances FDA UNII substance identifier D5340Y2I9G UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"D5340Y2I9G"}
openFDA substances FDA UNII substance identifier D5340Y2I9G UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"D5340Y2I9G"}