Saturated Methylene Diphenyl Diisocyanate

INCI: SATURATED METHYLENE DIPHENYL DIISOCYANATE

CAS Number
5124-30-1 (hydrogenated/saturated MDI)
Function
Polymerization agent (film-forming, binding in nail/hair products)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically addressed for cosmetics; EPA flags MDI-related compounds for respiratory/dermal sensitization [^1_11]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

H315 (skin irritation), H317 (skin sensitization), H334 (respiratory sensitization), H351 (suspected carcinogen); causes asthma, lung damage, potentially fatal reactions in severe cases [^1_12][^1_11]

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Saturated Methylene Diphenyl Diisocyanate safe in cosmetics?

H315 (skin irritation), H317 (skin sensitization), H334 (respiratory sensitization), H351 (suspected carcinogen); causes asthma, lung damage, potentially fatal reactions in severe cases [^1_12][^1_11] The EU classifies Saturated Methylene Diphenyl Diisocyanate as "permitted". Safety rating: POOR.

Is Saturated Methylene Diphenyl Diisocyanate allowed in the EU?

Saturated Methylene Diphenyl Diisocyanate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Saturated Methylene Diphenyl Diisocyanate do in cosmetics?

Saturated Methylene Diphenyl Diisocyanate functions as: Polymerization agent (film-forming, binding in nail/hair products). It is classified as a cosmetic ingredient in our database. CAS number: 5124-30-1 (hydrogenated/saturated MDI).

What is the Margin of Safety for Saturated Methylene Diphenyl Diisocyanate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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