Is sh-Octapeptide-4 safe in cosmetics?
sh-Octapeptide-4 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
sh-Octapeptide-4
INCI: SH-OCTAPEPTIDE-4
sh-Octapeptide-4 (CAS Not publicly assigned; CosIng Ref No. 87459) is a cosmetic cosmetic ingredient functioning as Anti-seborrheic, Antioxidant, Chelating, Reducing, Skin Protecting — synthetic. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS Not publicly assigned; CosIng Ref No. 87459 →
Function
Anti-seborrheic, Antioxidant, Chelating, Reducing, Skin Protecting — synthetic Leu-Enkephalin analogue (neuropeptide)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; enkephalin-mimetic nature could draw scrutiny if opioid receptor claims are made
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for sh-Octapeptide-4.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for sh-Octapeptide-4 — not a computed safety verdict. See the sourced toxicological data above.
Frequently Asked Questions
Is sh-Octapeptide-4 allowed in the EU?
sh-Octapeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does sh-Octapeptide-4 do in cosmetics?
sh-Octapeptide-4 functions as: Anti-seborrheic, Antioxidant, Chelating, Reducing, Skin Protecting — synthetic Leu-Enkephalin analogue (neuropeptide). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned; CosIng Ref No. 87459.
Compliance Tools
Check sh-Octapeptide-4 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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