Regulatory Status
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Safety Data
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Expert Verdict
This is a Leu-Enkephalin mimetic — an endogenous opioid peptide. While cosmetic concentrations are extremely low and dermal absorption minimal, the biological identity should be documented in safety dossiers. Anti-dandruff claims (anti-seborrheic) may also trigger regulatory attention in some jurisdictions
Frequently Asked Questions
Is sh-Octapeptide-4 safe in cosmetics?
This is a Leu-Enkephalin mimetic — an endogenous opioid peptide. While cosmetic concentrations are extremely low and dermal absorption minimal, the biological identity should be documented in safety dossiers. Anti-dandruff claims (anti-seborrheic) may also trigger regulatory attention in some jurisdictions The EU classifies sh-Octapeptide-4 as "permitted". Safety rating: MODERATE.
Is sh-Octapeptide-4 allowed in the EU?
sh-Octapeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does sh-Octapeptide-4 do in cosmetics?
sh-Octapeptide-4 functions as: Anti-seborrheic, Antioxidant, Chelating, Reducing, Skin Protecting — synthetic Leu-Enkephalin analogue (neuropeptide). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned; CosIng Ref No. 87459.
What is the Margin of Safety for sh-Octapeptide-4?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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