NOAEL Studies Cosmetic Ingredient

Sodium Acetate NOAEL Studies

INCI: SODIUM ACETATE

CAS: 127-09-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 102 mg/kg bw/day rat oral 135 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 21 mg/kg bw/day rat oral 90 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >30 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1517; Record_ID=acute_inhalation_3067; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2027044; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=30; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027044
NTP_ICE_acute_oral 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2049; row=4210; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium acetate; preferred_name=Sodium acetate; dtxsid=DTXSID2027044; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027044; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3530 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_2051; row=4211; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium acetate; preferred_name=Sodium acetate; dtxsid=DTXSID2027044; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027044; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3160 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_2048; row=4212; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium acetate; preferred_name=Sodium acetate; dtxsid=DTXSID2027044; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027044; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1943 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_2044; row=4213; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium acetate; preferred_name=Sodium acetate; dtxsid=DTXSID2027044; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027044; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2700 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_2046; row=4214; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium acetate; preferred_name=Sodium acetate; dtxsid=DTXSID2027044; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027044; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 <4640 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_2053; row=4215; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium acetate; preferred_name=Sodium acetate; dtxsid=DTXSID2027044; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027044; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=3600 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2c60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15311/7/6/2?documentUUID=d984b6e7-ca5f-47f6-a1c1-10ac83df52d0; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15837072:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f84b1b204e943ed8e5abef508828a7f
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b651b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15311/7/9/2?documentUUID=d984b6e7-ca5f-47f6-a1c1-10ac83df52d0; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860713_15861623:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_21c5a0b003b40446fec278c5c66aeb29
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1057.9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634726:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf094970a0bc9441eb4fdbe44121319f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier NVG71ZZ7P0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H3O2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NVG71ZZ7P0"}
openFDA substances FDA UNII substance identifier NVG71ZZ7P0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H3O2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NVG71ZZ7P0"}
openFDA substances FDA UNII substance identifier NVG71ZZ7P0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H3O2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NVG71ZZ7P0"}
openFDA substances FDA UNII substance identifier NVG71ZZ7P0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H3O2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NVG71ZZ7P0"}