NOAEL Studies Cosmetic Ingredient

Sodium Chlorate NOAEL Studies

INCI: SODIUM CHLORATE

CAS: 7775-09-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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INCHEM_WHO_jecfa_jecmono_v59je01 108 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-0.030.03 mg/kg bw/day Rat - two-generation Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=6181315523d6fba8; raw_unit=mg/kg bw; context=For chlorite, the Committee established an ADI of 0-0.03 mg/kg bw on the basis of the NOAEL of 3 mg/kg bw per day for reduced liver weight of F0 females and F1 males and females in a two-generation reproductive study in rats and a safety factor of 100 to allow for inter- and intraspecies variability.
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-0.010.01 mg/kg bw/day Rat - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=d888e9e8950b4106; raw_unit=mg/kg bw; context=The Committee therefore established an ADI of 0-0.01 mg/kg bw for chlorate on the basis of the BMDL10 of 1.1 mg/kg bw per day for non-neoplastic effects on the thyroid of male rats in a recent carcinogenicity study, a safety factor of 10 to allow for intraspecies variability and an additional factor of 10 to allow for t
INCHEM_WHO_jecfa_jecmono_v59je01 ADI =1.9 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ad439e4779a8e7f1; raw_unit=mg/kg bw; context=This ADI was expressed as (anhydrous) CaNa2EDTA and is equivalent to 1.9 mg/kg bw when expressed as EDTA.
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-2.52.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=7f0c741ac4753a3f; raw_unit=mg/kg bw; context=ron EDTA may lead to an intake of EDTA in infants and children up to the age of 13 that is at or exceeds the acceptable level of 1.9 mg/ kg bw for EDTA (i.e. the equivalent of the ADI of 0-2.5 mg/kg bw for calcium disodium EDTA and disodium EDTA).
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-2020 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=72b0906f8778eb86; raw_unit=mg/kg body weight; context=925) and assigned an ADI of 0-20 mg/kg body weight (bw) (Annex 1, reference 7).
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-22 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=e5b9279ef68f41e1; raw_unit=mg/kg bw; context=Steviol glycosides R The temporary ADI of 0-2 mg/kg bw for steviol glycosides, expressed as steviol, was extended until 2008, pending submission of the results of the ongoing studies.
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-0.030.03 mg/kg bw/day Rat - two-generation Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=6181315523d6fba8; raw_unit=mg/kg bw; context=For chlorite, the Committee established an ADI of 0-0.03 mg/kg bw on the basis of the NOAEL of 3 mg/kg bw per day for reduced liver weight of F0 females and F1 males and females in a two-generation reproductive study in rats and a safety factor of 100 to allow for inter- and intraspecies variability.
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-0.010.01 mg/kg bw/day Rat - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=d888e9e8950b4106; raw_unit=mg/kg bw; context=The Committee therefore established an ADI of 0-0.01 mg/kg bw for chlorate on the basis of the BMDL10 of 1.1 mg/kg bw per day for non-neoplastic effects on the thyroid of male rats in a recent carcinogenicity study, a safety factor of 10 to allow for intraspecies variability and an additional factor of 10 to allow for t
INCHEM_WHO_jecfa_jecmono_v59je01 ADI =1.9 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ad439e4779a8e7f1; raw_unit=mg/kg bw; context=This ADI was expressed as (anhydrous) CaNa2EDTA and is equivalent to 1.9 mg/kg bw when expressed as EDTA.
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-2.52.5 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=7f0c741ac4753a3f; raw_unit=mg/kg bw; context=ron EDTA may lead to an intake of EDTA in infants and children up to the age of 13 that is at or exceeds the acceptable level of 1.9 mg/ kg bw for EDTA (i.e. the equivalent of the ADI of 0-2.5 mg/kg bw for calcium disodium EDTA and disodium EDTA).
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-2020 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=72b0906f8778eb86; raw_unit=mg/kg body weight; context=925) and assigned an ADI of 0-20 mg/kg body weight (bw) (Annex 1, reference 7).
INCHEM_WHO_jecfa_jecmono_v59je01 ADI range:0-22 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=e5b9279ef68f41e1; raw_unit=mg/kg bw; context=Steviol glycosides R The temporary ADI of 0-2 mg/kg bw for steviol glycosides, expressed as steviol, was extended until 2008, pending submission of the results of the ongoing studies.
INCHEM_WHO_jecfa_jecmono_v59je01 LOAEL =19 mg/kg bw/day Rat oral 13-week Subchronic toxicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=09410fe4a9bcf8ca; raw_unit=mg/kg bw per day; context=For effects on erythrocytes, the lowest LOAEL of 19 mg/kg bw per day, expressed as chlorite, was derived from a 13-week gavage study in rats in which the NOAEL was 7.4 mg/kg bw per day, expressed as chlorite.
INCHEM_WHO_jecfa_jecmono_v59je01 LOAEL =19 mg/kg bw/day Rat oral 13-week Subchronic toxicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=09410fe4a9bcf8ca; raw_unit=mg/kg bw per day; context=For effects on erythrocytes, the lowest LOAEL of 19 mg/kg bw per day, expressed as chlorite, was derived from a 13-week gavage study in rats in which the NOAEL was 7.4 mg/kg bw per day, expressed as chlorite.
INCHEM_WHO_jecfa_jecmono_v59je01 LOEL =5 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ab4075f297238104; raw_unit=mg/kg bw per day; context=These three studies indicate a NOEL of 0.5 mg/kg bw per day, or 0.37 mg/kg bw per day expressed as chlorite, and a lowest-observed-effect level (LOEL) of 5 mg/kg bw per day, or 3.7 mg/kg bw per day expressed as chlorite, although the accuracy of these doses is dependent on the assumptions made.
INCHEM_WHO_jecfa_jecmono_v59je01 LOEL =0.00114285714285714 mg/kg bw/day Pig - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=96a2c51c44e8636b; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; converted from weekly dose; context=The Committee established a provisional tolerable weekly intake (PTWI) of 112 ng/kg body weight (bw), on the basis of deterioration of renal function in pigs, for which the lowest-observed-effect level (LOEL) was 8 ug/kg bw per day, and application of a safety factor of 500.
INCHEM_WHO_jecfa_jecmono_v59je01 LOEL =5 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ab4075f297238104; raw_unit=mg/kg bw per day; context=These three studies indicate a NOEL of 0.5 mg/kg bw per day, or 0.37 mg/kg bw per day expressed as chlorite, and a lowest-observed-effect level (LOEL) of 5 mg/kg bw per day, or 3.7 mg/kg bw per day expressed as chlorite, although the accuracy of these doses is dependent on the assumptions made.
INCHEM_WHO_jecfa_jecmono_v59je01 LOEL =0.00114285714285714 mg/kg bw/day Pig - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=96a2c51c44e8636b; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; converted from weekly dose; context=The Committee established a provisional tolerable weekly intake (PTWI) of 112 ng/kg body weight (bw), on the basis of deterioration of renal function in pigs, for which the lowest-observed-effect level (LOEL) was 8 ug/kg bw per day, and application of a safety factor of 500.
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =30 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=961393944f6639e6; raw_unit=mg/kg bw per day; context=A NOAEL of 30 mg/kg bw per day was identified from this study (McCauley et al., 1995).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =360 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=35c97922bb389089; raw_unit=mg/kg bw per day; context=A NOAEL of 360 mg/kg bw per day was identified (282 mg/kg bw per day expressed as chlorate) (Bio/dynamics Inc., 1987a).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =70 mg/L - oral - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=e84ec82f1e7a2aeb; raw_unit=mg/l; context=The authors concluded that the lowest NOAEL for sodium chlorite was 70 mg/l in drinking-water or 8 mg/kg bw per day for males and 10 mg/kg bw per day for females (Gill et al., 2000).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =1000 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=56237157cd3f731a; raw_unit=mg/kg bw per day; context=A NOAEL of 1000 mg/kg bw per day was identified from this study (Bio/dynamics Inc., 1987b).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =7.4 mg/kg bw/day Rat oral 13-week Subchronic toxicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=c92197b645f5b73e; raw_unit=mg/kg bw per day; context=For effects on erythrocytes, the lowest LOAEL of 19 mg/kg bw per day, expressed as chlorite, was derived from a 13-week gavage study in rats in which the NOAEL was 7.4 mg/kg bw per day, expressed as chlorite.
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =3 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=2fee82d7c3139a63; raw_unit=mg/kg bw per day; context=The Committee concluded that the low dose in this study, equivalent to 3 mg/kg bw per day, expressed as chlorite, was the NOAEL.
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =0.003 mg/kg bw/day Rat oral 5 days Carcinogenicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=9b14b1f32ed4ed09; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; converted from weekly dose; context=gavage administration of ochratoxin A to rats at the same doses that gave rise to renal tumour formation in the 2-year rat study (70 and 210 ug/kg bw per day, 5 days/week), with a NOAEL for cell proliferation at the same dose as that where no increase in tumour formation was observed in the 2-year rat study (21 ug/kg bw per day, 5 days/week).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =30 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=961393944f6639e6; raw_unit=mg/kg bw per day; context=A NOAEL of 30 mg/kg bw per day was identified from this study (McCauley et al., 1995).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =360 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=35c97922bb389089; raw_unit=mg/kg bw per day; context=A NOAEL of 360 mg/kg bw per day was identified (282 mg/kg bw per day expressed as chlorate) (Bio/dynamics Inc., 1987a).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =70 mg/L - oral - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=e84ec82f1e7a2aeb; raw_unit=mg/l; context=The authors concluded that the lowest NOAEL for sodium chlorite was 70 mg/l in drinking-water or 8 mg/kg bw per day for males and 10 mg/kg bw per day for females (Gill et al., 2000).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =1000 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=56237157cd3f731a; raw_unit=mg/kg bw per day; context=A NOAEL of 1000 mg/kg bw per day was identified from this study (Bio/dynamics Inc., 1987b).
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =7.4 mg/kg bw/day Rat oral 13-week Subchronic toxicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=c92197b645f5b73e; raw_unit=mg/kg bw per day; context=For effects on erythrocytes, the lowest LOAEL of 19 mg/kg bw per day, expressed as chlorite, was derived from a 13-week gavage study in rats in which the NOAEL was 7.4 mg/kg bw per day, expressed as chlorite.
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =3 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=2fee82d7c3139a63; raw_unit=mg/kg bw per day; context=The Committee concluded that the low dose in this study, equivalent to 3 mg/kg bw per day, expressed as chlorite, was the NOAEL.
INCHEM_WHO_jecfa_jecmono_v59je01 NOAEL =0.003 mg/kg bw/day Rat oral 5 days Carcinogenicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=9b14b1f32ed4ed09; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; converted from weekly dose; context=gavage administration of ochratoxin A to rats at the same doses that gave rise to renal tumour formation in the 2-year rat study (70 and 210 ug/kg bw per day, 5 days/week), with a NOAEL for cell proliferation at the same dose as that where no increase in tumour formation was observed in the 2-year rat study (21 ug/kg bw per day, 5 days/week).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =3 mg/kg bw/day Mouse oral - Developmental toxicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=9cb540ad2861b8af; raw_unit=mg/kg bw per day; context=fects on startle amplitude, decreased absolute brain weight in the F1 and F2 generations and altered liver weights in two generations were treatment related and concluded that the NOEL was 3 mg/kg bw per day expressed as chlorite. (ii) Developmental toxicity Groups of 10-12 female A/J mice were given 0 or 100 mg chlorite/l (in the form of sodium chlorite) in their drinking-water throughout pregnancy and lactation.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.5 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=98c62d83ce0a4fdc; raw_unit=mg/kg bw per day; context=These three studies indicate a NOEL of 0.5 mg/kg bw per day, or 0.37 mg/kg bw per day expressed as chlorite, and a lowest-observed-effect level (LOEL) of 5 mg/kg bw per day, or 3.7 mg/kg bw per day expressed as chlorite, although the accuracy of these doses is dependent on the assumptions made.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =250 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=9a0bd9ba618d3d4a; raw_unit=mg/kg bw per day; context=The NOEL of 250 mg/kg bw per day (Butterworth et al., 1975) for the related substance methyl sulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1.4 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=53e69a75bc2976be; raw_unit=mg/kg bw per day; context=The NOEL of 1.4 mg/kg bw per day for the related substance 2- (methylthiomethyl)-3-phenylpropenal (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.3 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=3cf9c3e75fece97b; raw_unit=mg/kg bw per day; context=The NOEL of 0.3 mg/kg bw per day for the related substance 3-methyl-1,2,4- trithiane (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=310f6d45b8377ce2; raw_unit=mg/kg bw per day; context=The NOEL of 0.7 mg/kg bw per day for the related substance 2-mercapto-3- butanol (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1.9 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ebaac3a553c65dbf; raw_unit=mg/kg bw per day; context=The NOEL of 1.9 mg/kg bw per day for the related substance 3-mercapto-2- pentanone (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =6.5 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=bc944ea3bbd98457; raw_unit=mg/kg bw per day; context=The NOEL of 6.5 mg/kg bw per day for the related substance ethyl thioacetate (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =10 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=1aba9cbbcea79604; raw_unit=mg/kg bw per day; context=The NOEL of 10 mg/kg bw per day (Finlay, 2004) is >1 million times the estimated daily intake of (±)-2,8-epithio- cis-p-menthane when used as a flavouring agent.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.56 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=7171c80eb57802be; raw_unit=mg/kg bw per day; context=The NOEL of 0.56 mg/kg bw per day for the related substance cyclopentanethiol (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.43 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=f57d21b91738130b; raw_unit=mg/kg bw per day; context=The NOEL of 0.43 mg/kg bw per day for the related substance 2,6- dimethylthiophenol (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.51 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=04cb8544c7aed719; raw_unit=mg/kg bw per day; context=0.03 The NOEL of 0.51 mg/kg bw per day for the related substance 2- mercaptomethylbenzene (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =7.3 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ac14741f0c02c353; raw_unit=mg/kg bw per day; context=The NOEL of 7.3 mg/kg bw per day for the related substance propyl disulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =4.6 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ed7d123d4cdf86ae; raw_unit=mg/kg bw per day; context=The NOEL of 4.6 mg/kg bw per day for the related substance diallyl trisulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =4.8 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=7f8daccd2fb3d5cc; raw_unit=mg/kg bw per day; context=The NOEL of 4.8 mg/kg bw per day for the related substance dipropyl trisulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =125 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=a77ecfcbf81c164e; raw_unit=mg/kg bw per day; context=1660), the NOEL of 125 mg/kg bw per day for one hydrolysis product, acetaldehyde (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =15 mg/kg bw/day Rat inhalation 2-year Chronic toxicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=7603e18eefc32050; raw_unit=mg/kg bw per day; context=1661), the NOEL of 15 mg/kg bw per day for one hydrolysis product, formaldehyde, from a 2-year study in rats (Til et al., 1989) and the NOEL of 6.5 mg/kg bw per day for the other hydrolysis product, hydrogen sulfide, from a 90-day inhalation study in rats (Chemical Industry Institute of Technology
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =43 mg/m3 Rat - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=9178a318573918be; raw_unit=mg/m3; context=Based on the results, the authors determined a NOEL of 43 mg/m3 (6.5 mg/kg bw per day) in rats (Chemical Industry Institute of Technology, 1983).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =2500 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=eaa62577d001d5c4; raw_unit=mg/kg bw per day; context=The NOEL of 2500 mg/kg bw per day (Gaunt et al., 1972) for the non- endogenous metabolite propylene glycol (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =290 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ed34a16afba849a6; raw_unit=mg/kg bw per day; context=The NOEL of 290 mg/kg bw per day (Morgareidge & Oser, 1970) for the related substance 2- thienyldisulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.93 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=28db627671c19e19; raw_unit=mg/kg bw per day; context=The NOEL of 0.93 mg/kg bw per day (Posternak et al., 1969) for the related substance 2,4- dimethyl-5-vinylthiazole (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1.8 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=8dc9b28ef630880a; raw_unit=mg/kg bw per day; context=The NOEL of 1.8 mg/kg bw per day (Munday & Kirkby, 1971b) is 18 000 and 30 000 times the estimated daily intake of 2-acetyl-2-thiazoline when used as a flavouring agent in Europe and Japan, respectively.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=b8b2d935fe840e5c; raw_unit=mg/kg bw per day; context=The NOEL of 1.2 mg/kg bw per day (Babish, 1978) for the related substance 2-(2- butyl)-4,5-dimethyl-3- thiazoline (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =11 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=766d7733ccf64540; raw_unit=mg/kg bw per day; context=The NOEL of 11 mg/kg bw per day (Rush, 1989a, 1989b) for the mixture of related substances 2- isobutyl-4,6- dimethyldihydro-1,3,5- dithiazine and 4- isobutyl-2,6- See note 1 No safety concern SULFUR-CONTAINING HETEROCYCLIC COMPOUNDS 257 Table 1 (contd) Flavouring agent No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =2e-7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=65940c2f9ee58a12; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is >1 billion times the estimated intake of 1-(3-hydroxy-5-methyl-2-thienyl)ethanone and 3-(methylthio)methylthiophene from their use as flavouring agents in Europe (0.0002 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.00002 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=66e20dbd1b73be8a; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is >14 million times the estimated intake of 2-hexylthiophene from its use as a flavouring agent in Europe (0.02 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =4e-7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=3766c04163bf6df1; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is >2 million times the estimated intake of 2,5-dimethylthiazole from its use as a flavouring agent in Japan (0.0004 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.000003 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=4c5857b30313d385; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is >3 million times the estimated intake of 5-acetyl-2,3-dihydro-1,4-thiazine from its use as a flavouring agent in the USA (0.003 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.0001 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=2e15ecb767db75c0; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is 12 000 times the estimated intake of 2- acetyl-2-thiazoline from its use as a flavouring agent in Europe (0.1 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =25 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=6bb9ea23e1a41ea6; raw_unit=mg/ kg bw per day; context=The NOEL was 25 mg/ kg bw per day (Nagao, 2006). (c) Genotoxicity (i) Thiophene (structurally related substance) The results of several in vitro tests for genotoxicity conducted with thiophene, a structurally related compound, are described below.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =20 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=182df49010e67c0b; raw_unit=mg/kg bw per day; context=The NOEL of 20 mg/kg bw per day (Kot, 2005a) is 10 million times the estimated daily intake of N-(heptan-4-yl)benzo- [d][1,3]dioxole-5-carboxamide when used as a flavouring agent.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =100 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=06ece79b9a84b0ae; raw_unit=mg/kg bw per day; context=The NOEL of 100 mg/kg bw per day (Kot, 2005b) is >33 million times the estimated daily intake of N1-(2,4- dimethoxybenzyl)-N2-(2- (pyridin-2-yl)ethyl)oxalamide when used as a flavouring agent.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =8 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=eaffad0efae83b8d; raw_unit=mg/kg bw per day; context=The NOEL of 8 mg/kg bw per day for the related substance N-ethyl 2- isopropyl-5-methylcyclo- hexanecarboxamide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =8.36 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=f51cad5485045ff0; raw_unit=mg/kg bw per day; context=The NOEL of 8.36 mg/kg bw per day for the related substance N-nonanoyl-4- hydroxy-3- methoxybenzylamide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =92 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=460274acaf9a6e5b; raw_unit=mg/kg bw per day; context=The NOEL of 92 mg/kg bw per day (Merkel, 2005) is >180 000 times greater than the estimated daily intake of N-3,7- dimethyl-2,6-octadienyl cyclopropylcarboxamide when used as a flavouring agent.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1100 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=bb15dc469a61202b; raw_unit=mg/kg; context=ALIPHATIC AND AROMATIC AMINES AND AMIDES 293 Under the conditions of this study and based on the toxicological end-points evaluated, the NOEL was the highest dose tested-namely, 1100 mg/kg, equivalent to 92 and 97 mg/kg bw per day in the non-recovery group male and female rats, respectively, and 94 and 97 mg/kg bw per day in the recovery group male and female rats, respectively (Everds, 2005;
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL range:120-180180 mg/kg bw/day Rat oral 98-day Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=246a895222fb7afd; raw_unit=mg/kg bw per day; context=In a 98-day rat drinking-water study, cis-3- hexen-1-ol exhibited a NOEL of 120-180 mg/kg bw per day (Gaunt et al., 1969).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =3 mg/kg bw/day Mouse oral - Developmental toxicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=9cb540ad2861b8af; raw_unit=mg/kg bw per day; context=fects on startle amplitude, decreased absolute brain weight in the F1 and F2 generations and altered liver weights in two generations were treatment related and concluded that the NOEL was 3 mg/kg bw per day expressed as chlorite. (ii) Developmental toxicity Groups of 10-12 female A/J mice were given 0 or 100 mg chlorite/l (in the form of sodium chlorite) in their drinking-water throughout pregnancy and lactation.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.5 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=98c62d83ce0a4fdc; raw_unit=mg/kg bw per day; context=These three studies indicate a NOEL of 0.5 mg/kg bw per day, or 0.37 mg/kg bw per day expressed as chlorite, and a lowest-observed-effect level (LOEL) of 5 mg/kg bw per day, or 3.7 mg/kg bw per day expressed as chlorite, although the accuracy of these doses is dependent on the assumptions made.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =250 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=9a0bd9ba618d3d4a; raw_unit=mg/kg bw per day; context=The NOEL of 250 mg/kg bw per day (Butterworth et al., 1975) for the related substance methyl sulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1.4 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=53e69a75bc2976be; raw_unit=mg/kg bw per day; context=The NOEL of 1.4 mg/kg bw per day for the related substance 2- (methylthiomethyl)-3-phenylpropenal (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.3 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=3cf9c3e75fece97b; raw_unit=mg/kg bw per day; context=The NOEL of 0.3 mg/kg bw per day for the related substance 3-methyl-1,2,4- trithiane (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=310f6d45b8377ce2; raw_unit=mg/kg bw per day; context=The NOEL of 0.7 mg/kg bw per day for the related substance 2-mercapto-3- butanol (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1.9 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ebaac3a553c65dbf; raw_unit=mg/kg bw per day; context=The NOEL of 1.9 mg/kg bw per day for the related substance 3-mercapto-2- pentanone (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =6.5 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=bc944ea3bbd98457; raw_unit=mg/kg bw per day; context=The NOEL of 6.5 mg/kg bw per day for the related substance ethyl thioacetate (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =10 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=1aba9cbbcea79604; raw_unit=mg/kg bw per day; context=The NOEL of 10 mg/kg bw per day (Finlay, 2004) is >1 million times the estimated daily intake of (±)-2,8-epithio- cis-p-menthane when used as a flavouring agent.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.56 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=7171c80eb57802be; raw_unit=mg/kg bw per day; context=The NOEL of 0.56 mg/kg bw per day for the related substance cyclopentanethiol (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.43 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=f57d21b91738130b; raw_unit=mg/kg bw per day; context=The NOEL of 0.43 mg/kg bw per day for the related substance 2,6- dimethylthiophenol (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.51 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=04cb8544c7aed719; raw_unit=mg/kg bw per day; context=0.03 The NOEL of 0.51 mg/kg bw per day for the related substance 2- mercaptomethylbenzene (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =7.3 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ac14741f0c02c353; raw_unit=mg/kg bw per day; context=The NOEL of 7.3 mg/kg bw per day for the related substance propyl disulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =4.6 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ed7d123d4cdf86ae; raw_unit=mg/kg bw per day; context=The NOEL of 4.6 mg/kg bw per day for the related substance diallyl trisulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =4.8 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=7f8daccd2fb3d5cc; raw_unit=mg/kg bw per day; context=The NOEL of 4.8 mg/kg bw per day for the related substance dipropyl trisulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =125 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=a77ecfcbf81c164e; raw_unit=mg/kg bw per day; context=1660), the NOEL of 125 mg/kg bw per day for one hydrolysis product, acetaldehyde (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =15 mg/kg bw/day Rat inhalation 2-year Chronic toxicity document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=7603e18eefc32050; raw_unit=mg/kg bw per day; context=1661), the NOEL of 15 mg/kg bw per day for one hydrolysis product, formaldehyde, from a 2-year study in rats (Til et al., 1989) and the NOEL of 6.5 mg/kg bw per day for the other hydrolysis product, hydrogen sulfide, from a 90-day inhalation study in rats (Chemical Industry Institute of Technology
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =43 mg/m3 Rat - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=9178a318573918be; raw_unit=mg/m3; context=Based on the results, the authors determined a NOEL of 43 mg/m3 (6.5 mg/kg bw per day) in rats (Chemical Industry Institute of Technology, 1983).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =2500 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=eaa62577d001d5c4; raw_unit=mg/kg bw per day; context=The NOEL of 2500 mg/kg bw per day (Gaunt et al., 1972) for the non- endogenous metabolite propylene glycol (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =290 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=ed34a16afba849a6; raw_unit=mg/kg bw per day; context=The NOEL of 290 mg/kg bw per day (Morgareidge & Oser, 1970) for the related substance 2- thienyldisulfide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.93 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=28db627671c19e19; raw_unit=mg/kg bw per day; context=The NOEL of 0.93 mg/kg bw per day (Posternak et al., 1969) for the related substance 2,4- dimethyl-5-vinylthiazole (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1.8 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=8dc9b28ef630880a; raw_unit=mg/kg bw per day; context=The NOEL of 1.8 mg/kg bw per day (Munday & Kirkby, 1971b) is 18 000 and 30 000 times the estimated daily intake of 2-acetyl-2-thiazoline when used as a flavouring agent in Europe and Japan, respectively.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=b8b2d935fe840e5c; raw_unit=mg/kg bw per day; context=The NOEL of 1.2 mg/kg bw per day (Babish, 1978) for the related substance 2-(2- butyl)-4,5-dimethyl-3- thiazoline (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =11 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=766d7733ccf64540; raw_unit=mg/kg bw per day; context=The NOEL of 11 mg/kg bw per day (Rush, 1989a, 1989b) for the mixture of related substances 2- isobutyl-4,6- dimethyldihydro-1,3,5- dithiazine and 4- isobutyl-2,6- See note 1 No safety concern SULFUR-CONTAINING HETEROCYCLIC COMPOUNDS 257 Table 1 (contd) Flavouring agent No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =2e-7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=65940c2f9ee58a12; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is >1 billion times the estimated intake of 1-(3-hydroxy-5-methyl-2-thienyl)ethanone and 3-(methylthio)methylthiophene from their use as flavouring agents in Europe (0.0002 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.00002 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=66e20dbd1b73be8a; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is >14 million times the estimated intake of 2-hexylthiophene from its use as a flavouring agent in Europe (0.02 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =4e-7 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=3766c04163bf6df1; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is >2 million times the estimated intake of 2,5-dimethylthiazole from its use as a flavouring agent in Japan (0.0004 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.000003 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=4c5857b30313d385; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is >3 million times the estimated intake of 5-acetyl-2,3-dihydro-1,4-thiazine from its use as a flavouring agent in the USA (0.003 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =0.0001 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=2e15ecb767db75c0; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The NOEL is 12 000 times the estimated intake of 2- acetyl-2-thiazoline from its use as a flavouring agent in Europe (0.1 ug/kg bw per day).
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =25 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=6bb9ea23e1a41ea6; raw_unit=mg/ kg bw per day; context=The NOEL was 25 mg/ kg bw per day (Nagao, 2006). (c) Genotoxicity (i) Thiophene (structurally related substance) The results of several in vitro tests for genotoxicity conducted with thiophene, a structurally related compound, are described below.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =20 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=182df49010e67c0b; raw_unit=mg/kg bw per day; context=The NOEL of 20 mg/kg bw per day (Kot, 2005a) is 10 million times the estimated daily intake of N-(heptan-4-yl)benzo- [d][1,3]dioxole-5-carboxamide when used as a flavouring agent.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =100 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=06ece79b9a84b0ae; raw_unit=mg/kg bw per day; context=The NOEL of 100 mg/kg bw per day (Kot, 2005b) is >33 million times the estimated daily intake of N1-(2,4- dimethoxybenzyl)-N2-(2- (pyridin-2-yl)ethyl)oxalamide when used as a flavouring agent.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =8 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=eaffad0efae83b8d; raw_unit=mg/kg bw per day; context=The NOEL of 8 mg/kg bw per day for the related substance N-ethyl 2- isopropyl-5-methylcyclo- hexanecarboxamide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =8.36 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=f51cad5485045ff0; raw_unit=mg/kg bw per day; context=The NOEL of 8.36 mg/kg bw per day for the related substance N-nonanoyl-4- hydroxy-3- methoxybenzylamide (No.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =92 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=460274acaf9a6e5b; raw_unit=mg/kg bw per day; context=The NOEL of 92 mg/kg bw per day (Merkel, 2005) is >180 000 times greater than the estimated daily intake of N-3,7- dimethyl-2,6-octadienyl cyclopropylcarboxamide when used as a flavouring agent.
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL =1100 mg/kg bw/day Rat - - Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=bb15dc469a61202b; raw_unit=mg/kg; context=ALIPHATIC AND AROMATIC AMINES AND AMIDES 293 Under the conditions of this study and based on the toxicological end-points evaluated, the NOEL was the highest dose tested-namely, 1100 mg/kg, equivalent to 92 and 97 mg/kg bw per day in the non-recovery group male and female rats, respectively, and 94 and 97 mg/kg bw per day in the recovery group male and female rats, respectively (Everds, 2005;
INCHEM_WHO_jecfa_jecmono_v59je01 NOEL range:120-180180 mg/kg bw/day Rat oral 98-day Toxicology study document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=246a895222fb7afd; raw_unit=mg/kg bw per day; context=In a 98-day rat drinking-water study, cis-3- hexen-1-ol exhibited a NOEL of 120-180 mg/kg bw per day (Gaunt et al., 1969).
INCHEM_WHO_jecfa_jecmono_v59je01 TDI =0.8 mg/kg bw/day - oral - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=d3317712b490abca; raw_unit=mg/ kg bw; context=For iron, the Committee at its twenty-seventh meeting (Annex 1, reference 62) had allocated a provisional maximum tolerable daily intake (PMTDI) of 0.8 mg/ kg bw to iron from all sources, except for iron oxides and hydrated iron oxides used as food colouring agents and iron supplements taken during pregnancy and lactation or for specific clinical requirements.
INCHEM_WHO_jecfa_jecmono_v59je01 TDI =0.8 mg/kg bw/day - oral - Health guidance value document_id=jecfa_jecmono_v59je01; title=Who Food Additives Series 59 Safety Evaluation Of Certain Food Additives And Contaminants; path=mirror/documents/jecfa/jecmono/v59je01.pdf; row_hash=d3317712b490abca; raw_unit=mg/ kg bw; context=For iron, the Committee at its twenty-seventh meeting (Annex 1, reference 62) had allocated a provisional maximum tolerable daily intake (PMTDI) of 0.8 mg/ kg bw to iron from all sources, except for iron oxides and hydrated iron oxides used as food colouring agents and iron supplements taken during pregnancy and lactation or for specific clinical requirements.
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >28 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=3983; Record_ID=acute_inhalation_3290; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7026025; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=28; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026025; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026025
NTP_ICE_cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer POLY-3 lowest dose 2000 mg/L Rat Dosed drinking water - In Vivo; Two year cancer bioassay sheet=Data; excel_row=8292; Record_ID=cancer_88; Data_Type=In Vivo; Formulation_Name=Water disinfection byproducts (Sodium chlorate); Mixture=Chemical; DTXSID=DTXSID7026025; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=2000; Response_Unit=mg/L; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed drinking water; Level_of_Evidence=Some evidence; Tissue=Thyroid gland; Location=Follicular cell; Lesion=Carcinoma or adenoma; Reference=TR-517; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr517/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026025; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026025
NTP_ICE_cancer Top dose 2000 mg/L Mouse Dosed drinking water - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=8290; Record_ID=cancer_83; Data_Type=In Vivo; Formulation_Name=Water Disinfection Byproducts (Sodium Chlorate); Mixture=Chemical; DTXSID=DTXSID7026025; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=mg/L; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed drinking water; Reference=TR-517; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr517/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026025; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026025
ToxRefDB_ToxRefDB_v3_pod.csv 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxRefDB_ToxRefDB_v3_pod.csv LEL =1000 mg/kg bw/day rat oral 0 day to 90 day SUB study_id=5059; toxval_study_source_id=studyid5059_Adult_F0_F_systemic; toxval_effect_list=hematology-reticulocyte-reticulocyte|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-adrenal gland-nos|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct); dose_level=3; study_year=1987; study_citation=Barrett, DS. 1987. A subchronic (3 month) oral toxicity study of sodium chlorate in the rat via gavage. Biodynamics Inc., Study no. 86-3112. MRID 40444801.; dsstox_substance_id=DTXSID7026025; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =70 mg/kg bw/day rat (sprague dawley; Crl CD(SD) IGS BR) oral 10 weeks (premating) to 2 generation MGR study_id=5065; toxval_study_source_id=studyid5065_Adult_F0_F_systemic; toxval_effect_list=hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-thyroid gland-hyperplasia|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|pathology microscopic-thyroid gland-[other]; dose_level=2; study_year=2004; study_citation=Gaoua, W. 2004. Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats. CIT (France). Lab study no. 22824 RSR, Aug 19, 2004. MRID 46524001.; dsstox_substance_id=DTXSID7026025; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LOAEL =500 mg/kg bw/day rat (sprague dawley; Crl CD(SD) IGS BR) oral 10 weeks (premating) to 2 generation MGR study_id=5065; toxval_study_source_id=studyid5065_Adult_F0_F_systemic; toxval_effect_list=hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-thyroid gland-hyperplasia|pathology microscopic-thyroid gland-[other]; dose_level=3; study_year=2004; study_citation=Gaoua, W. 2004. Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats. CIT (France). Lab study no. 22824 RSR, Aug 19, 2004. MRID 46524001.; dsstox_substance_id=DTXSID7026025; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =100 mg/kg bw/day rat oral 0 day to 90 day SUB study_id=5059; toxval_study_source_id=studyid5059_Adult_F0_F_systemic; toxval_effect_list=organ weight-adrenal gland-nos|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-reticulocyte-reticulocyte|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb); dose_level=2; study_year=1987; study_citation=Barrett, DS. 1987. A subchronic (3 month) oral toxicity study of sodium chlorate in the rat via gavage. Biodynamics Inc., Study no. 86-3112. MRID 40444801.; dsstox_substance_id=DTXSID7026025; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =10 mg/kg bw/day rat (sprague dawley; Crl CD(SD) IGS BR) oral 10 weeks (premating) to 2 generation MGR study_id=5065; toxval_study_source_id=studyid5065_Adult_F0_F_systemic; toxval_effect_list=hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|pathology microscopic-thyroid gland-[other]|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-thyroid gland-hyperplasia; dose_level=1; study_year=2004; study_citation=Gaoua, W. 2004. Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats. CIT (France). Lab study no. 22824 RSR, Aug 19, 2004. MRID 46524001.; dsstox_substance_id=DTXSID7026025; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB_EPA_OPP 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_OPP PAD (RfD) =0.03 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP:15790114:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cfe8e862a092573e9596e84aff459b93
ToxValDB_GESTIS_DNEL 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634758_15634759_15634760:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6d3811021b039278c12af494230d0914
ToxValDB_GESTIS_DNEL DNEL systemic =2.468 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634758_15634759_15634760:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8b67e7944cb4e484b8024cefc99670f4
ToxValDB_GESTIS_DNEL DNEL systemic =5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634758_15634759_15634760:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f787170e9900f0b2a65491281df57aa
ToxValDB_ToxRefDB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ToxRefDB LEL =1000 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=Barrett, DS. 1987. A subchronic (3 month) oral toxicity study of sodium chlorate in the rat via gavage. Biodynamics Inc., Study no. 86-3112. MRID 40444801.; TITLE=A subchronic (3 month) oral toxicity study of sodium chlorate in the rat via gavage; AUTHOR=Barrett, DS; EXTERNAL_SOURCE_ID=5059; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-adrenal gland-nos|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc); TOXICOLOGICAL_EFFECT_CATEGORY=hematology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708362_15708363_15708364_15708365:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d98b58356279a2dfaaa02d03f170fce5
ToxValDB_ToxRefDB LEL =70 mg/kg bw/day Rat oral chronic (developmental) reproduction developmental LONG_REF=Gaoua, W. 2004. Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats. CIT (France). Lab study no. 22824 RSR, Aug 19, 2004. MRID 46524001.; TITLE=Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats; AUTHOR=Gaoua, W; EXTERNAL_SOURCE_ID=5065; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: pathology microscopic-thyroid gland-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708382_15708383_15708384_15708385:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11b2cc61243f35da1cc6f96bfe574ec5
ToxValDB_ToxRefDB LOAEL =500 mg/kg bw/day Rat oral chronic (developmental) reproduction developmental LONG_REF=Gaoua, W. 2004. Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats. CIT (France). Lab study no. 22824 RSR, Aug 19, 2004. MRID 46524001.; TITLE=Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats; AUTHOR=Gaoua, W; EXTERNAL_SOURCE_ID=5065; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: pathology microscopic-thyroid gland-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708382_15708383_15708384_15708385:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1923e8c91d97562b01a56b646ae16aa6
ToxValDB_ToxRefDB NEL =100 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=Barrett, DS. 1987. A subchronic (3 month) oral toxicity study of sodium chlorate in the rat via gavage. Biodynamics Inc., Study no. 86-3112. MRID 40444801.; TITLE=A subchronic (3 month) oral toxicity study of sodium chlorate in the rat via gavage; AUTHOR=Barrett, DS; EXTERNAL_SOURCE_ID=5059; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-adrenal gland-nos|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb); TOXICOLOGICAL_EFFECT_CATEGORY=hematology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708362_15708363_15708364_15708365:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a0e16863a05e2dbbbed150d47ab8eb8
ToxValDB_ToxRefDB NEL =10 mg/kg bw/day Rat oral chronic (developmental) reproduction developmental LONG_REF=Gaoua, W. 2004. Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats. CIT (France). Lab study no. 22824 RSR, Aug 19, 2004. MRID 46524001.; TITLE=Two-generation study (reproduction and fertility effects) by oral route (gavage) in rats; AUTHOR=Gaoua, W; EXTERNAL_SOURCE_ID=5065; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: pathology microscopic-thyroid gland-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708382_15708383_15708384_15708385:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb8d7c94f7903d4174a4b816b974f5ed
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier T95DR77GMR UNII - - - chemical {"approval_status":null,"molecular_formula":"ClO3.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T95DR77GMR"}
openFDA substances FDA UNII substance identifier T95DR77GMR UNII - - - chemical {"approval_status":null,"molecular_formula":"ClO3.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T95DR77GMR"}
openFDA substances FDA UNII substance identifier T95DR77GMR UNII - - - chemical {"approval_status":null,"molecular_formula":"ClO3.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T95DR77GMR"}
openFDA substances FDA UNII substance identifier T95DR77GMR UNII - - - chemical {"approval_status":null,"molecular_formula":"ClO3.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T95DR77GMR"}