NOAEL Studies Cosmetic Ingredient

Sodium Chloride NOAEL Studies

CAS: 7647-14-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 27 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1250 mg/kg bw/day rat oral 574 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2690 mg/kg bw/day rat oral 100 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 17500 mg/kg bw/day rat oral 92 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3500 mg/kg bw/day rat oral 427 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5500 mg/kg bw/day dog oral 1460 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 480 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 368 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3000 mg/kg bw/day rat oral 119 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1500 mg/kg bw/day monkey oral 56 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5600 mg/kg bw/day rat oral 280 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 214 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 196 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 250 mg/kg bw/day swine oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 259 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4000 mg/kg bw/day rat oral 35 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1010 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1900 mg/kg bw/day rat oral 49 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3949 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3085 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 800 mg/kg bw/day rat oral 1 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7000 mg/kg bw/day rat oral 21 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3850 mg/kg bw/day rat oral 126 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 357 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7700 mg/kg bw/day rat oral 28 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day rat oral 56 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7800 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7760 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >42 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1928; Record_ID=acute_inhalation_3280; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021271; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=42; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021271; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021271
ToxValDB_ECOTOX 26 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =4.5 mM/kg Dog injection acute; 0.0139 days acute LONG_REF=J. Clin. Invest.51(4): 831-836 Bottger,I., G.R. Faloona, and R.H. Unger The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut 1972; TITLE=The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut; AUTHOR=Bottger,I., G.R. Faloona, and R.H. Unger; DOI=10.1172/JCI106878; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=88479; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1972; ORIGINAL_YEAR=1972; TOXICOLOGICAL_EFFECT=Biochemistry: Glucagon-Like Peptides; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594207_15596733:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d12a49b1dcfb515d29b9c8615c4c4e21
ToxValDB_ECOTOX LOEL =25 % Rat oral acute; 0.0417 days acute LONG_REF=Acta Physiol. Hung.75(Suppl.): 217-218 Mozsik,G., M. Garamszegi, T. Javor, L. Nagy, M. Nemeth, G. Suto, and A. Vincze Chemical (Alcohol, NaOH, NaCl and HCl)-Induced Changes in the Gastric Mucosal Membrane-Bound ATP-Dependent Energy Systems 1990; TITLE=Chemical (Alcohol, NaOH, NaCl and HCl)-Induced Changes in the Gastric Mucosal Membrane-Bound ATP-Dependent Energy Systems; AUTHOR=Mozsik,G., M. Garamszegi, T. Javor, L. Nagy, M. Nemeth, G. Suto, and A. Vincze; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=103894; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Biochemistry: Adenosine triphosphate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595326:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fe3e2ec5cc20c3134cc7efe1fa8fba6c
ToxValDB_ECOTOX LOEL =1 % Rat oral chronic; 365.28 days chronic LONG_REF=Jpn. J. Cancer Res.83:1267-1272 Watanabe,H., T. Okamoto, T. Takahashi, P.O. Ogundigie, and A. Ito The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia After X-Irradiation of the Rat Glandular Stomach 1992; TITLE=The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia After X-Irradiation of the Rat Glandular Stomach; AUTHOR=Watanabe,H., T. Okamoto, T. Takahashi, P.O. Ogundigie, and A. Ito; DOI=10.1111/j.1349-7006.1992.tb02757.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107468; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Morphology: Height; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597092_15607096_15607097_15610403:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cd62b800b6b5a4c8ef7d316b0c7eb644
ToxValDB_ECOTOX LOEL =10 % Rat oral subchronic; 56 days subchronic LONG_REF=Toxicol. Appl. Pharmacol.99(1): 37-49 Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters 1989; TITLE=Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters; AUTHOR=Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima; DOI=10.1016/0041-008x(89)90109-9; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=106692; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: Potassium content|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598413_15598414_15598415:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d626e7c6d93139e0d637aeab46d5013f
ToxValDB_ECOTOX LOEL =2 % Rat oral subchronic; 35 days subchronic LONG_REF=Carcinogenesis12(12): 2201-2204 Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl 1991; TITLE=Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl; AUTHOR=Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi; DOI=10.1093/carcin/12.12.2201; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106693; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598434_15598435_15598436_15605077_15608040:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1e363bf775dde0d940a2ff270ca23f5b
ToxValDB_ECOTOX LOEL =2600 mM Rat oral short-term; 2 days short-term LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15600541:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=41eafbd53c70e5d454cdf961702652d1
ToxValDB_ECOTOX LOEL =8 % Rat oral chronic; 91 days chronic LONG_REF=Clin. Exp. Hypertens. Part A Theory Pract.11(7): 1217-1234 Wauquier,I., and M.A. Devynck Body Fluid Variations and Endogenous Digitalis-Like Compounds During Chronic NaCl Loading in Wistar Rats 1989; TITLE=Body Fluid Variations and Endogenous Digitalis-Like Compounds During Chronic NaCl Loading in Wistar Rats; AUTHOR=Wauquier,I., and M.A. Devynck; DOI=10.3109/10641968909038166; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=111912; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: Hematocrit (anemia)|Enzyme(s): Sodium potassium ATPase|Growth: Weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|gross pathology|hematology; STUDY_GROUP=ECOTOX:15603365:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=56c98ceab30f30644cc938d0f813727c
ToxValDB_ECOTOX LOEL =0.25 % Rat oral subchronic; 35 days subchronic LONG_REF=Carcinogenesis12(12): 2201-2204 Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl 1991; TITLE=Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl; AUTHOR=Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi; DOI=10.1093/carcin/12.12.2201; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106693; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598434_15598435_15598436_15605077_15608040:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=288751b69159add69bc1ecc7293e1d3c
ToxValDB_ECOTOX LOEL =2.02 % diet Rat oral subchronic; 70 days subchronic LONG_REF=Carcinogenesis16(2): 343-348 Cohen,S.M., M. Cano, E.M. Garland, M. St.John, and L.L. Arnold Urinary and Urothelial Effects of Sodium Salts in Male Rats 1995; TITLE=Urinary and Urothelial Effects of Sodium Salts in Male Rats; AUTHOR=Cohen,S.M., M. Cano, E.M. Garland, M. St.John, and L.L. Arnold; DOI=10.1093/carcin/16.2.343; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=111191; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: Creatinine|Morphology: Weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606352_15606353:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9d7f56fdc6914f469ed722fe09c0a21f
ToxValDB_ECOTOX LOEL =500 mg/kg bw/day Rat oral acute; 0.0556 days acute LONG_REF=Mutat. Res.287(2): 307-319 Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui Ability of N-Methyl-N\'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in 1993; TITLE=Ability of N-Methyl-N'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in; AUTHOR=Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui; DOI=10.1016/0027-5107(93)90023-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107920; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606356_15606357:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7fdc75053935b4eacfa1915f2a8406a9
ToxValDB_ECOTOX LOEL =3.12 % Rat oral subchronic; 63 days subchronic LONG_REF=Regulatory Pept.140(1/2): 5-11 Carillo,B.A., A. Beutel, D.A. Mirandola, A.F.,Jr. Vidonho, L.N.S. Furukawa, D. Casarini, R.R. Campos, M.S. Dolnikoff, J Differential Sympathetic and Angiotensinergic Responses in Rats Submitted to Low- or High-Salt Diet 2007; TITLE=Differential Sympathetic and Angiotensinergic Responses in Rats Submitted to Low- or High-Salt Diet; AUTHOR=Carillo,B.A., A. Beutel, D.A. Mirandola, A.F.,Jr. Vidonho, L.N.S. Furukawa, D. Casarini, R.R. Campos, M.S. Dolnikoff, J; DOI=10.1016/j.regpep.2006.11.007; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106168; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Enzyme(s): Renin|Genetics: Actin mRNA|Growth: Weight|Morphology: Organ weight in relationship to body weight|Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|organ weight|other|urinalysis; STUDY_GROUP=ECOTOX:15606962:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bac527b86004b4ea0843377d4c6b34c0
ToxValDB_ECOTOX LOEL =1000 mg/kg bw/day Rat oral acute; 0.6667 days acute LONG_REF=Mutat. Res.287(2): 307-319 Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui Ability of N-Methyl-N\'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in 1993; TITLE=Ability of N-Methyl-N'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in; AUTHOR=Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui; DOI=10.1016/0027-5107(93)90023-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107920; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15607975:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1f82484110352e51338312e2af2a4646
ToxValDB_ECOTOX LOEL =12 % Rat oral subchronic; 84 days subchronic LONG_REF=Environ. Toxicol. Pharmacol.20(1): 57-64 Vences-Mejia,A., H. Caballero-Ortega, V. Dorado-Gonzalez, A. Gamboa-Dominguez, C. Gomez-Ruiz, R. Camacho-Carranza, and Cytochrome P450 Expression in Rat Gastric Epithelium with Intestinal Metaplasia Induced by High Dietary NaCl Levels 2005; TITLE=Cytochrome P450 Expression in Rat Gastric Epithelium with Intestinal Metaplasia Induced by High Dietary NaCl Levels; AUTHOR=Vences-Mejia,A., H. Caballero-Ortega, V. Dorado-Gonzalez, A. Gamboa-Dominguez, C. Gomez-Ruiz, R. Camacho-Carranza, and; DOI=10.1016/j.etap.2004.10.010; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106211; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Enzyme(s): 7-Ethoxyresorufin O-deethylase|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608280_15608281_15608282:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1eab75b4bb4e77c9ad43fdabaf59dd66
ToxValDB_ECOTOX LOEL =6 % Rat oral subchronic; 84 days subchronic LONG_REF=Environ. Toxicol. Pharmacol.20(1): 57-64 Vences-Mejia,A., H. Caballero-Ortega, V. Dorado-Gonzalez, A. Gamboa-Dominguez, C. Gomez-Ruiz, R. Camacho-Carranza, and Cytochrome P450 Expression in Rat Gastric Epithelium with Intestinal Metaplasia Induced by High Dietary NaCl Levels 2005; TITLE=Cytochrome P450 Expression in Rat Gastric Epithelium with Intestinal Metaplasia Induced by High Dietary NaCl Levels; AUTHOR=Vences-Mejia,A., H. Caballero-Ortega, V. Dorado-Gonzalez, A. Gamboa-Dominguez, C. Gomez-Ruiz, R. Camacho-Carranza, and; DOI=10.1016/j.etap.2004.10.010; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106211; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608280_15608281_15608282:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=414911693654a216bb14e22400b1cfaf
ToxValDB_ECOTOX LOEL =1300 mM Rat oral acute; 0.7083 days acute LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608921_15608922:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0c6dd257f3df9f5249089d285242cb88
ToxValDB_ECOTOX LOEL =50 mmol/kg diet Rat oral short-term; 15 days short-term LONG_REF=J. Med. Res. Inst.16(1): 34-46 Zaki,K., S.M. Elwa, M.M. Mossaad, F.I. Nasr, and S.M. El Kholy Changes of Some Electrolytes and Trace Elements in Serum and Atrial Tissue of Rat Under Different Doses of Sodium Chloride Intake 1995; TITLE=Changes of Some Electrolytes and Trace Elements in Serum and Atrial Tissue of Rat Under Different Doses of Sodium Chloride Intake; AUTHOR=Zaki,K., S.M. Elwa, M.M. Mossaad, F.I. Nasr, and S.M. El Kholy; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78870; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Potassium content; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15609206:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1ce7cde9bd7483c816f069a936ee5981
ToxValDB_ECOTOX LOEL =400 mg/kg bw/day Rat oral acute; 0.7083 days acute LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609488_15610022:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f87c9e38e640d3724dcf506406ec2b3a
ToxValDB_ECOTOX LOEL =460 mg/kg bw/day Rat oral acute; 0.7083 days acute LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609488_15610022:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c4460ca28aa000a34a6caca80f2b7a05
ToxValDB_ECOTOX NOEL =50 uL Rat injection short-term; 5 days short-term LONG_REF=Regulatory Pept.119(3): 155-161 Deng,P.Y., F. Ye, W.J. Cai, H.W. Deng, and Y.J. Li Role of Calcitonin Gene-Related Peptide in the Phenol-Induced Neurogenic Hypertension in Rats 2004; TITLE=Role of Calcitonin Gene-Related Peptide in the Phenol-Induced Neurogenic Hypertension in Rats; AUTHOR=Deng,P.Y., F. Ye, W.J. Cai, H.W. Deng, and Y.J. Li; DOI=10.1016/j.regpep.2004.01.011; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=107000; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15595251:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=eb6fec55d19d5c1566ff5e7fbc041de0
ToxValDB_ECOTOX NOEL =9 mM/kg Dog injection acute; 0.125 days acute LONG_REF=J. Clin. Invest.51(4): 831-836 Bottger,I., G.R. Faloona, and R.H. Unger The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut 1972; TITLE=The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut; AUTHOR=Bottger,I., G.R. Faloona, and R.H. Unger; DOI=10.1172/JCI106878; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=88479; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1972; ORIGINAL_YEAR=1972; TOXICOLOGICAL_EFFECT=Hormone(s): Insulin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15596360:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fa6091c97069e12fb1c3027a1a3dedce
ToxValDB_ECOTOX NOEL =1 % Rat oral subchronic; 56 days subchronic LONG_REF=Cancer Lett.63(1): 1-5 Asamoto,M., K. Imaida, R. Hasegawa, K. Hotta, and S. Fukushima Change of Membrane Potential in Rat Urinary Bladder Epithelium Treated with Sodium L-Ascorbate 1992; TITLE=Change of Membrane Potential in Rat Urinary Bladder Epithelium Treated with Sodium L-Ascorbate; AUTHOR=Asamoto,M., K. Imaida, R. Hasegawa, K. Hotta, and S. Fukushima; DOI=10.1016/0304-3835(92)90082-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=110233; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Physiology: Membrane Potential; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX:15597923:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ef48bdbeed1b89b7cc9183af07529a0f
ToxValDB_ECOTOX NOEL =100000 ppm Rat oral short-term; 21 days short-term LONG_REF=J. Am. Coll. Nutr.12(6): 714-719 Wapnir,R.A., and S.Y. Lee Dietary Regulation of Copper Absorption and Storage in Rats: Effects of Sodium, Zinc and Histidine-Zinc 1993; TITLE=Dietary Regulation of Copper Absorption and Storage in Rats: Effects of Sodium, Zinc and Histidine-Zinc; AUTHOR=Wapnir,R.A., and S.Y. Lee; DOI=10.1080/07315724.1993.10718364; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86642; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Copper (Cu) content|Biochemistry: Metallothionein|Biochemistry: Zinc content|Growth: Weight|Physiology: Copper uptake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15598295:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c895ae026eeda2bd130c1a6f6387c85c
ToxValDB_ECOTOX NOEL =4 % Rat oral subchronic; 35 days subchronic LONG_REF=Carcinogenesis12(12): 2201-2204 Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl 1991; TITLE=Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl; AUTHOR=Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi; DOI=10.1093/carcin/12.12.2201; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106693; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598434_15598435_15598436_15605077_15608040:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9339ed53b2c08f23f09ae3fcb3023466
ToxValDB_ECOTOX NOEL =1.7 % Rat oral subchronic; 56 days subchronic LONG_REF=Jpn. J. Cancer Res.83(8): 821-829 Shibata,M.A., S. Tamano, T. Shirai, M. Kawabe, and S. Fukushima Inorganic Alkalizers and Acidifiers Under Conditions of High Urinary Na+ or K+ on Cell Proliferation and Two-Stage Carcinogenesis in the Rat Bladder 1992; TITLE=Inorganic Alkalizers and Acidifiers Under Conditions of High Urinary Na+ or K+ on Cell Proliferation and Two-Stage Carcinogenesis in the Rat Bladder; AUTHOR=Shibata,M.A., S. Tamano, T. Shirai, M. Kawabe, and S. Fukushima; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107672; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate|Histology: Hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599211_15606747:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=912b4d2b4901b1b2bf630b91fe643766
ToxValDB_ECOTOX NOEL =250 mg/kg bw/day Rat oral acute; 0.0556 days acute LONG_REF=Mutat. Res.287(2): 307-319 Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui Ability of N-Methyl-N\'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in 1993; TITLE=Ability of N-Methyl-N'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in; AUTHOR=Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui; DOI=10.1016/0027-5107(93)90023-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107920; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606356_15606357:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a6466573b3225d7cd809f45345e7128
ToxValDB_ECOTOX NOEL =650 mM Rat oral acute; 0.7083 days acute LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608921_15608922:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=47aa7e0ef990d4d3d9db2d657f13c14f
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =2068.62 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634761:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f6a36e03f27cbed8bd62733a25006241
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=5 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afa11e4b0d99f5a878f1c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/166; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=WHO JECFA ADI:15715328:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_683e01ecd48e041b4303f50fedd4e0a0
openFDA substances 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 451W47IQ8X UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"451W47IQ8X"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier VR5Y7PDT5W UNII - - - specifiedSubstanceG1 {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"specifiedSubstanceG1","unii_code":"VR5Y7PDT5W"}
openFDA substances FDA UNII substance identifier L8527B28XP UNII - - - chemical {"approval_status":null,"molecular_formula":"C32H68N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L8527B28XP"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier 451W47IQ8X UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"451W47IQ8X"}
openFDA substances FDA UNII substance identifier 451W47IQ8X UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"451W47IQ8X"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier VR5Y7PDT5W UNII - - - specifiedSubstanceG1 {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"specifiedSubstanceG1","unii_code":"VR5Y7PDT5W"}
openFDA substances FDA UNII substance identifier VR5Y7PDT5W UNII - - - specifiedSubstanceG1 {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"specifiedSubstanceG1","unii_code":"VR5Y7PDT5W"}
openFDA substances FDA UNII substance identifier 451W47IQ8X UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"451W47IQ8X"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier L8527B28XP UNII - - - chemical {"approval_status":null,"molecular_formula":"C32H68N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L8527B28XP"}
openFDA substances FDA UNII substance identifier L8527B28XP UNII - - - chemical {"approval_status":null,"molecular_formula":"C32H68N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L8527B28XP"}
openFDA substances FDA UNII substance identifier VR5Y7PDT5W UNII - - - specifiedSubstanceG1 {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"specifiedSubstanceG1","unii_code":"VR5Y7PDT5W"}
openFDA substances FDA UNII substance identifier L8527B28XP UNII - - - chemical {"approval_status":null,"molecular_formula":"C32H68N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L8527B28XP"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}