NOAEL Studies Cosmetic Ingredient

Sodium Chloride NOAEL Studies

CAS: 7647-14-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 27 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 250 mg/kg bw/day swine oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 368 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 480 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 259 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 800 mg/kg bw/day rat oral 1 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 214 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1010 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1250 mg/kg bw/day rat oral 574 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1500 mg/kg bw/day monkey oral 56 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1900 mg/kg bw/day rat oral 49 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2000 mg/kg bw/day rat oral 56 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2500 mg/kg bw/day rat oral 357 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2690 mg/kg bw/day rat oral 100 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3000 mg/kg bw/day rat oral 119 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3085 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3500 mg/kg bw/day rat oral 427 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3850 mg/kg bw/day rat oral 126 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3949 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 4000 mg/kg bw/day rat oral 35 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5000 mg/kg bw/day rat oral 196 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5500 mg/kg bw/day dog oral 1460 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5600 mg/kg bw/day rat oral 280 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 7000 mg/kg bw/day rat oral 21 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 7700 mg/kg bw/day rat oral 28 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 7760 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 7800 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 17500 mg/kg bw/day rat oral 92 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >42 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1928; Record_ID=acute_inhalation_3280; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021271; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=42; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021271; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021271
ToxValDB ECOTOX 26 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =0.25 % Rat oral subchronic; 35 days subchronic LONG_REF=Carcinogenesis12(12): 2201-2204 Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl 1991; TITLE=Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl; AUTHOR=Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi; DOI=10.1093/carcin/12.12.2201; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106693; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598434_15598435_15598436_15605077_15608040:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=288751b69159add69bc1ecc7293e1d3c
ToxValDB ECOTOX LOEL =1 % Rat oral chronic; 365.28 days chronic LONG_REF=Jpn. J. Cancer Res.83:1267-1272 Watanabe,H., T. Okamoto, T. Takahashi, P.O. Ogundigie, and A. Ito The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia After X-Irradiation of the Rat Glandular Stomach 1992; TITLE=The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia After X-Irradiation of the Rat Glandular Stomach; AUTHOR=Watanabe,H., T. Okamoto, T. Takahashi, P.O. Ogundigie, and A. Ito; DOI=10.1111/j.1349-7006.1992.tb02757.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107468; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Morphology: Height; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597092_15607096_15607097_15610403:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cd62b800b6b5a4c8ef7d316b0c7eb644
ToxValDB ECOTOX LOEL =2 % Rat oral subchronic; 35 days subchronic LONG_REF=Carcinogenesis12(12): 2201-2204 Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl 1991; TITLE=Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl; AUTHOR=Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi; DOI=10.1093/carcin/12.12.2201; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106693; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598434_15598435_15598436_15605077_15608040:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1e363bf775dde0d940a2ff270ca23f5b
ToxValDB ECOTOX LOEL =2.02 % diet Rat oral subchronic; 70 days subchronic LONG_REF=Carcinogenesis16(2): 343-348 Cohen,S.M., M. Cano, E.M. Garland, M. St.John, and L.L. Arnold Urinary and Urothelial Effects of Sodium Salts in Male Rats 1995; TITLE=Urinary and Urothelial Effects of Sodium Salts in Male Rats; AUTHOR=Cohen,S.M., M. Cano, E.M. Garland, M. St.John, and L.L. Arnold; DOI=10.1093/carcin/16.2.343; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=111191; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: Creatinine|Morphology: Weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606352_15606353:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9d7f56fdc6914f469ed722fe09c0a21f
ToxValDB ECOTOX LOEL =3.12 % Rat oral subchronic; 63 days subchronic LONG_REF=Regulatory Pept.140(1/2): 5-11 Carillo,B.A., A. Beutel, D.A. Mirandola, A.F.,Jr. Vidonho, L.N.S. Furukawa, D. Casarini, R.R. Campos, M.S. Dolnikoff, J Differential Sympathetic and Angiotensinergic Responses in Rats Submitted to Low- or High-Salt Diet 2007; TITLE=Differential Sympathetic and Angiotensinergic Responses in Rats Submitted to Low- or High-Salt Diet; AUTHOR=Carillo,B.A., A. Beutel, D.A. Mirandola, A.F.,Jr. Vidonho, L.N.S. Furukawa, D. Casarini, R.R. Campos, M.S. Dolnikoff, J; DOI=10.1016/j.regpep.2006.11.007; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106168; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Enzyme(s): Renin|Genetics: Actin mRNA|Growth: Weight|Morphology: Organ weight in relationship to body weight|Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|organ weight|other|urinalysis; STUDY_GROUP=ECOTOX:15606962:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bac527b86004b4ea0843377d4c6b34c0
ToxValDB ECOTOX LOEL =4.5 mM/kg Dog injection acute; 0.0139 days acute LONG_REF=J. Clin. Invest.51(4): 831-836 Bottger,I., G.R. Faloona, and R.H. Unger The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut 1972; TITLE=The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut; AUTHOR=Bottger,I., G.R. Faloona, and R.H. Unger; DOI=10.1172/JCI106878; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=88479; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1972; ORIGINAL_YEAR=1972; TOXICOLOGICAL_EFFECT=Biochemistry: Glucagon-Like Peptides; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594207_15596733:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d12a49b1dcfb515d29b9c8615c4c4e21
ToxValDB ECOTOX LOEL =6 % Rat oral subchronic; 84 days subchronic LONG_REF=Environ. Toxicol. Pharmacol.20(1): 57-64 Vences-Mejia,A., H. Caballero-Ortega, V. Dorado-Gonzalez, A. Gamboa-Dominguez, C. Gomez-Ruiz, R. Camacho-Carranza, and Cytochrome P450 Expression in Rat Gastric Epithelium with Intestinal Metaplasia Induced by High Dietary NaCl Levels 2005; TITLE=Cytochrome P450 Expression in Rat Gastric Epithelium with Intestinal Metaplasia Induced by High Dietary NaCl Levels; AUTHOR=Vences-Mejia,A., H. Caballero-Ortega, V. Dorado-Gonzalez, A. Gamboa-Dominguez, C. Gomez-Ruiz, R. Camacho-Carranza, and; DOI=10.1016/j.etap.2004.10.010; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106211; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608280_15608281_15608282:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=414911693654a216bb14e22400b1cfaf
ToxValDB ECOTOX LOEL =8 % Rat oral chronic; 91 days chronic LONG_REF=Clin. Exp. Hypertens. Part A Theory Pract.11(7): 1217-1234 Wauquier,I., and M.A. Devynck Body Fluid Variations and Endogenous Digitalis-Like Compounds During Chronic NaCl Loading in Wistar Rats 1989; TITLE=Body Fluid Variations and Endogenous Digitalis-Like Compounds During Chronic NaCl Loading in Wistar Rats; AUTHOR=Wauquier,I., and M.A. Devynck; DOI=10.3109/10641968909038166; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=111912; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: Hematocrit (anemia)|Enzyme(s): Sodium potassium ATPase|Growth: Weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|gross pathology|hematology; STUDY_GROUP=ECOTOX:15603365:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=56c98ceab30f30644cc938d0f813727c
ToxValDB ECOTOX LOEL =10 % Rat oral subchronic; 56 days subchronic LONG_REF=Toxicol. Appl. Pharmacol.99(1): 37-49 Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters 1989; TITLE=Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters; AUTHOR=Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima; DOI=10.1016/0041-008x(89)90109-9; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=106692; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: Potassium content|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598413_15598414_15598415:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d626e7c6d93139e0d637aeab46d5013f
ToxValDB ECOTOX LOEL =12 % Rat oral subchronic; 84 days subchronic LONG_REF=Environ. Toxicol. Pharmacol.20(1): 57-64 Vences-Mejia,A., H. Caballero-Ortega, V. Dorado-Gonzalez, A. Gamboa-Dominguez, C. Gomez-Ruiz, R. Camacho-Carranza, and Cytochrome P450 Expression in Rat Gastric Epithelium with Intestinal Metaplasia Induced by High Dietary NaCl Levels 2005; TITLE=Cytochrome P450 Expression in Rat Gastric Epithelium with Intestinal Metaplasia Induced by High Dietary NaCl Levels; AUTHOR=Vences-Mejia,A., H. Caballero-Ortega, V. Dorado-Gonzalez, A. Gamboa-Dominguez, C. Gomez-Ruiz, R. Camacho-Carranza, and; DOI=10.1016/j.etap.2004.10.010; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106211; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Enzyme(s): 7-Ethoxyresorufin O-deethylase|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608280_15608281_15608282:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1eab75b4bb4e77c9ad43fdabaf59dd66
ToxValDB ECOTOX LOEL =25 % Rat oral acute; 0.0417 days acute LONG_REF=Acta Physiol. Hung.75(Suppl.): 217-218 Mozsik,G., M. Garamszegi, T. Javor, L. Nagy, M. Nemeth, G. Suto, and A. Vincze Chemical (Alcohol, NaOH, NaCl and HCl)-Induced Changes in the Gastric Mucosal Membrane-Bound ATP-Dependent Energy Systems 1990; TITLE=Chemical (Alcohol, NaOH, NaCl and HCl)-Induced Changes in the Gastric Mucosal Membrane-Bound ATP-Dependent Energy Systems; AUTHOR=Mozsik,G., M. Garamszegi, T. Javor, L. Nagy, M. Nemeth, G. Suto, and A. Vincze; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=103894; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Biochemistry: Adenosine triphosphate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595326:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fe3e2ec5cc20c3134cc7efe1fa8fba6c
ToxValDB ECOTOX LOEL =50 mmol/kg diet Rat oral short-term; 15 days short-term LONG_REF=J. Med. Res. Inst.16(1): 34-46 Zaki,K., S.M. Elwa, M.M. Mossaad, F.I. Nasr, and S.M. El Kholy Changes of Some Electrolytes and Trace Elements in Serum and Atrial Tissue of Rat Under Different Doses of Sodium Chloride Intake 1995; TITLE=Changes of Some Electrolytes and Trace Elements in Serum and Atrial Tissue of Rat Under Different Doses of Sodium Chloride Intake; AUTHOR=Zaki,K., S.M. Elwa, M.M. Mossaad, F.I. Nasr, and S.M. El Kholy; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78870; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Potassium content; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15609206:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1ce7cde9bd7483c816f069a936ee5981
ToxValDB ECOTOX LOEL =400 mg/kg bw/day Rat oral acute; 0.7083 days acute LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609488_15610022:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f87c9e38e640d3724dcf506406ec2b3a
ToxValDB ECOTOX LOEL =460 mg/kg bw/day Rat oral acute; 0.7083 days acute LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609488_15610022:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c4460ca28aa000a34a6caca80f2b7a05
ToxValDB ECOTOX LOEL =500 mg/kg bw/day Rat oral acute; 0.0556 days acute LONG_REF=Mutat. Res.287(2): 307-319 Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui Ability of N-Methyl-N\'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in 1993; TITLE=Ability of N-Methyl-N'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in; AUTHOR=Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui; DOI=10.1016/0027-5107(93)90023-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107920; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606356_15606357:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7fdc75053935b4eacfa1915f2a8406a9
ToxValDB ECOTOX LOEL =1000 mg/kg bw/day Rat oral acute; 0.6667 days acute LONG_REF=Mutat. Res.287(2): 307-319 Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui Ability of N-Methyl-N\'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in 1993; TITLE=Ability of N-Methyl-N'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in; AUTHOR=Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui; DOI=10.1016/0027-5107(93)90023-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107920; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15607975:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1f82484110352e51338312e2af2a4646
ToxValDB ECOTOX LOEL =1300 mM Rat oral acute; 0.7083 days acute LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608921_15608922:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0c6dd257f3df9f5249089d285242cb88
ToxValDB ECOTOX LOEL =2600 mM Rat oral short-term; 2 days short-term LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15600541:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=41eafbd53c70e5d454cdf961702652d1
ToxValDB ECOTOX NOEL =1 % Rat oral subchronic; 56 days subchronic LONG_REF=Cancer Lett.63(1): 1-5 Asamoto,M., K. Imaida, R. Hasegawa, K. Hotta, and S. Fukushima Change of Membrane Potential in Rat Urinary Bladder Epithelium Treated with Sodium L-Ascorbate 1992; TITLE=Change of Membrane Potential in Rat Urinary Bladder Epithelium Treated with Sodium L-Ascorbate; AUTHOR=Asamoto,M., K. Imaida, R. Hasegawa, K. Hotta, and S. Fukushima; DOI=10.1016/0304-3835(92)90082-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=110233; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Physiology: Membrane Potential; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX:15597923:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ef48bdbeed1b89b7cc9183af07529a0f
ToxValDB ECOTOX NOEL =1.7 % Rat oral subchronic; 56 days subchronic LONG_REF=Jpn. J. Cancer Res.83(8): 821-829 Shibata,M.A., S. Tamano, T. Shirai, M. Kawabe, and S. Fukushima Inorganic Alkalizers and Acidifiers Under Conditions of High Urinary Na+ or K+ on Cell Proliferation and Two-Stage Carcinogenesis in the Rat Bladder 1992; TITLE=Inorganic Alkalizers and Acidifiers Under Conditions of High Urinary Na+ or K+ on Cell Proliferation and Two-Stage Carcinogenesis in the Rat Bladder; AUTHOR=Shibata,M.A., S. Tamano, T. Shirai, M. Kawabe, and S. Fukushima; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107672; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate|Histology: Hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599211_15606747:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=912b4d2b4901b1b2bf630b91fe643766
ToxValDB ECOTOX NOEL =4 % Rat oral subchronic; 35 days subchronic LONG_REF=Carcinogenesis12(12): 2201-2204 Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl 1991; TITLE=Enhanced Lipid Peroxidation in Rat Gastric Mucosa Caused by NaCl; AUTHOR=Takahashi,M., T. Hasegawa, F. Furukawa, H. Okamiya, K. Shinoda, K. Imaida, K. Toyoda, and Y. Hayashi; DOI=10.1093/carcin/12.12.2201; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=106693; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598434_15598435_15598436_15605077_15608040:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9339ed53b2c08f23f09ae3fcb3023466
ToxValDB ECOTOX NOEL =9 mM/kg Dog injection acute; 0.125 days acute LONG_REF=J. Clin. Invest.51(4): 831-836 Bottger,I., G.R. Faloona, and R.H. Unger The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut 1972; TITLE=The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut; AUTHOR=Bottger,I., G.R. Faloona, and R.H. Unger; DOI=10.1172/JCI106878; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=88479; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1972; ORIGINAL_YEAR=1972; TOXICOLOGICAL_EFFECT=Hormone(s): Insulin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15596360:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fa6091c97069e12fb1c3027a1a3dedce
ToxValDB ECOTOX NOEL =50 uL Rat injection short-term; 5 days short-term LONG_REF=Regulatory Pept.119(3): 155-161 Deng,P.Y., F. Ye, W.J. Cai, H.W. Deng, and Y.J. Li Role of Calcitonin Gene-Related Peptide in the Phenol-Induced Neurogenic Hypertension in Rats 2004; TITLE=Role of Calcitonin Gene-Related Peptide in the Phenol-Induced Neurogenic Hypertension in Rats; AUTHOR=Deng,P.Y., F. Ye, W.J. Cai, H.W. Deng, and Y.J. Li; DOI=10.1016/j.regpep.2004.01.011; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=107000; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15595251:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=eb6fec55d19d5c1566ff5e7fbc041de0
ToxValDB ECOTOX NOEL =250 mg/kg bw/day Rat oral acute; 0.0556 days acute LONG_REF=Mutat. Res.287(2): 307-319 Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui Ability of N-Methyl-N\'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in 1993; TITLE=Ability of N-Methyl-N'-Nitro-N-Nitrosoguanidine, 4-Nitroquinoline 1-Oxide, Dimethylnitrosamine, and NaCl to Induce Unscheduled DNA Synthesis, Stimulate Replicative DNA-Synthesis, and Produce DNA Single-Strand Breaks in; AUTHOR=Ohsawa,K.I., C. Furihata, M. Mori, and E. Ikui; DOI=10.1016/0027-5107(93)90023-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107920; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606356_15606357:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a6466573b3225d7cd809f45345e7128
ToxValDB ECOTOX NOEL =650 mM Rat oral acute; 0.7083 days acute LONG_REF=Carcinogenesis17(3): 401-406 Furihata,C., H. Ohta, and T. Katsuyama Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter 1996; TITLE=Cause and Effect Between Concentration-Dependent Tissue Damage and Temporary Cell Proliferation in Rat Stomach Mucosa by NaCl, a Stomach Tumor Promoter; AUTHOR=Furihata,C., H. Ohta, and T. Katsuyama; DOI=10.1093/carcin/17.3.401; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84213; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: DNA synthesis rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608921_15608922:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=47aa7e0ef990d4d3d9db2d657f13c14f
ToxValDB ECOTOX NOEL =100000 ppm Rat oral short-term; 21 days short-term LONG_REF=J. Am. Coll. Nutr.12(6): 714-719 Wapnir,R.A., and S.Y. Lee Dietary Regulation of Copper Absorption and Storage in Rats: Effects of Sodium, Zinc and Histidine-Zinc 1993; TITLE=Dietary Regulation of Copper Absorption and Storage in Rats: Effects of Sodium, Zinc and Histidine-Zinc; AUTHOR=Wapnir,R.A., and S.Y. Lee; DOI=10.1080/07315724.1993.10718364; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86642; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Copper (Cu) content|Biochemistry: Metallothionein|Biochemistry: Zinc content|Growth: Weight|Physiology: Copper uptake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15598295:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c895ae026eeda2bd130c1a6f6387c85c
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =2068.62 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634761:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f6a36e03f27cbed8bd62733a25006241
WHO/JECFA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA ADI <=5 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afa11e4b0d99f5a878f1c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/166; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=WHO JECFA ADI:15715328:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_683e01ecd48e041b4303f50fedd4e0a0
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 451W47IQ8X UNII - - - chemical -
openFDA substances FDA UNII substance identifier L8527B28XP UNII - - - chemical -
openFDA substances FDA UNII substance identifier VR5Y7PDT5W UNII - - - specifiedSubstanceG1 -
openFDA substances FDA UNII substance identifier concept identifier - - - concept -