NOAEL Studies
Cosmetic Ingredient
Sodium Chlorite NOAEL Studies
INCI: SODIUM CHLORITE
CAS: 7758-19-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 25 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; Journal of the American College of Toxicology, 14(1): 21-33, |
| COSMOS DB | NOAEL | 0.77 | mg/kg bw/day | rat | oral | 90 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1.7 | mg/kg bw/day | rat | oral | 95 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 4 | mg/kg bw/day | rat | oral | NA | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 7 | mg/kg bw/day | cat | oral | NA | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 10 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 21 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 23 | mg/kg bw/day | mouse | oral | 30 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 25 | mg/kg bw/day | mouse | oral | 48 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 32 | mg/kg bw/day | rat | oral | 595 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 50 | mg/kg bw/day | rat | oral | 72 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 53 | mg/kg bw/day | rabbit | oral | 14 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 59 | mg/kg bw/day | rat | oral | 365 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 63 | mg/kg bw/day | mouse | oral | 595 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 67 | mg/kg bw/day | mouse | oral | 560 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =3 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=df82808e6caf5fa0; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 3 mg/kg-day; system=Nervous, Developmental; basis=Neurodevelopmental effects; point_of_departure=NOAEL : 3 mg/kg-day; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID8021272; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=648; rfd_last_updated=10/12/2000; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0648_summary.pdf |
| Regulatory source | RfD | =0.03 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=5058a193f2f52b62; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-2; system=Nervous, Developmental; basis=Neurodevelopmental effects; point_of_departure=NOAEL : 3 mg/kg-day; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID8021272; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=648; rfd_last_updated=10/12/2000; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0648_summary.pdf |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1990 | IARC Monographs | - |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 0.23 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4377; Record_ID=acute_inhalation_3288; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021272; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.23; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021272; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021272 |
NTP ICE adme parameters 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 75.4 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3115; Record_ID=adme_parameters_1068; Data_Type=Measured; DTXSID=DTXSID8021272; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=75.4; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021272; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021272 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=8969; Record_ID=cancer_3943; Data_Type=WOE; Formulation_Name=Sodium chlorite; Mixture=Chemical; DTXSID=DTXSID8021272; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/70; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021272; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021272 |
NTP ICE dart 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 35.5 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=120527; Record_ID=dart_34497; Data_Type=In Vivo; DTXSID=DTXSID8021272; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=35.5; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0205394;CUI;Other|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 730; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021272; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021272 |
| NTP ICE dart | LOEL | 35.5 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=120528; Record_ID=dart_34494; Data_Type=In Vivo; DTXSID=DTXSID8021272; Assay=DART, In life observation; Endpoint=LOEL; Response=35.5; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0011135;CUI;Defecation; Reference=ToxRefDB v2 , ID = 730; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021272; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021272 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14470; RecordID=ARPathway2016_1553; DatasetName=ARPathway2016; DTXSID=DTXSID8021272; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021272; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021272 |
EPA ToxRefDB v3 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =35.5 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=730; toxval_study_source_id=studyid730_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-defecation|in life observation-water consumption-water consumption|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=2; study_year=1990; study_citation=Irvine, L. (1990) Sodium Chlorite: Rabbit Teratology Study (Drink- ing Water Administration): Lab Project Number: CMA/3/R. Unpub- lished study prepared by Toxicol Laboratories Ltd. 151 p.; dsstox_substance_id=DTXSID8021272; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =13 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=730; toxval_study_source_id=studyid730_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-water consumption-water consumption|in life observation-clinical signs-defecation; dose_level=1; study_year=1990; study_citation=Irvine, L. (1990) Sodium Chlorite: Rabbit Teratology Study (Drink- ing Water Administration): Lab Project Number: CMA/3/R. Unpub- lished study prepared by Toxicol Laboratories Ltd. 151 p.; dsstox_substance_id=DTXSID8021272; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ECHA 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf104; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/3?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=maternal: clinical signs|maternal: gross pathology|maternal: histopathology: non-neoplastic|maternal: mortality|maternal: necropsy findings; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823088_15825411:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48b6dcfc7cbc0e2e88bb2b5a4509804a |
| ECHA | LOAEL | =100 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd9e4b0a7c65d227d30; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/6/2?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=haematology|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|urinalysis; STUDY_GROUP=ECHA IUCLID:15849880:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9699245469d5a1c2623e035dee2c99a4 |
| ECHA | LOAEL | =300 | mg/L | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c62b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/2?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=P1: haematology; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858024_15858097_15858135_15858152:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_846f30d18fc709fc56bc859588d47e24 |
| ECHA | NOAEL | =1.9 | mg/kg bw/day | Mouse | oral | short-term; 30 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaefbe4b0a7c65d1cbe10; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/6/2?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID:15848830:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e566488eff5d23dabe31b3baccaac80f |
| ECHA | NOAEL | <5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf0fc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/3?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=maternal: gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823088_15825411:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8a5b2076a37b3dea45a6f41e7de9f3d2 |
| ECHA | NOAEL | =10 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/2?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID:15856243:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60f109023da9d8b149595134e7a7000e |
| ECHA | NOAEL | >25 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf0fc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/3?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID:15825183:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3eca891eb87b8ef78df7d26430434c27 |
| ECHA | NOAEL | =35 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c62b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/2?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=P0: water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15857531:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f8d3c1ad0e359ab493d4e949cb186a2 |
| ECHA | NOAEL | =70 | mg/L | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c62b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/2?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=P1: haematology; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858024_15858097_15858135_15858152:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1e7fd422caa1eff0c42501f1dc18c48f |
| ECHA | NOAEL | >75 | mg/L | Mouse | oral | short-term; 30 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd8e4b0a7c65d227d1c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/6/2?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID:15835624:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa93c536d9c8a40c3f8058e13617c362 |
| ECHA | NOAEL | >100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf104; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/3?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID:15825184:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_876540f36227d50a33f6bf014dca114a |
| ECHA | NOEL | >=32 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4788; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/8?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817281_15820221:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_55c74f4e928c3889c1288a755a2d3cd1 |
| ECHA | NOEL | >=32.1 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217864; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/8?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817281_15820221:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e01a35e5c705d40e5a0a7375a6cd9b64 |
| ECHA | NOEL | >=40.9 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217864; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/8?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816445_15820222:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef05036ec22112f9e0e09cb4984c911b |
| ECHA | NOEL | >=41 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4788; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/8?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816445_15820222:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f8b90f48c52462e95752beb9cc140829 |
| ECHA | NOEL | >=58 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d21786a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/8?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817483_15820224:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1360da91815b63dffa8826a89d3111d6 |
| ECHA | NOEL | >=83 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d21786a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/8?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID:15820223:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2aea9e1eb83470bdb192c8aadf93da68 |
| ECHA | NOEL | >=126 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b478c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/8?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817483_15820224:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8f48d0489c755c3ca6a6e7a23f112547 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.28 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634762:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b152b8825040db5d0877496095a30f6 |
ToxValDB RSL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfD | =0.03 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15654979:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1628c0cee3e2d7ce0e18940739968125 |
| ToxValDB RSL | RfD | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663260:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3f589b0fe7fc74afd7947bc0ab93f7c1 |
ToxValDB ToxRefDB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =35.5 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Irvine, L. (1990) Sodium Chlorite: Rabbit Teratology Study (Drink- ing Water Administration): Lab Project Number: CMA/3/R. Unpub- lished study prepared by Toxicol Laboratories Ltd. 151 p.; TITLE=Sodium Chlorite: Rabbit Teratology Study (Drink- ing Water Administration): Lab Project Number: CMA/3/R; AUTHOR=Irvine, L; EXTERNAL_SOURCE_ID=730; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-defecation|systemic: in life observation-water consumption-water consumption|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15682259_15682260_15682261_15682262:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8fd29af61c175f6224e407817461aa7e |
| ToxValDB ToxRefDB | NEL | =13 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Irvine, L. (1990) Sodium Chlorite: Rabbit Teratology Study (Drink- ing Water Administration): Lab Project Number: CMA/3/R. Unpub- lished study prepared by Toxicol Laboratories Ltd. 151 p.; TITLE=Sodium Chlorite: Rabbit Teratology Study (Drink- ing Water Administration): Lab Project Number: CMA/3/R; AUTHOR=Irvine, L; EXTERNAL_SOURCE_ID=730; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-water consumption-water consumption|systemic: in life observation-clinical signs-defecation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15682259_15682260_15682261_15682262:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ffffa3d8a81adb6ff1e612c975f1c267 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | G538EBV4VF | UNII | - | - | - | chemical | - |