Is Sodium Cholate safe in cosmetics?
Sodium Cholate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Sodium Cholate
Also known as: Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3-alpha,5-beta,7-alpha,12-alpha)-, EINECS 206-643-5, Trihydroxy 3-7-12 cholanate de Na, UNII-NU3Y4CCH8Z, Cholate
INCI: SODIUM CHOLATE
Sodium Cholate (CAS 361-09-1) is a cosmetic cosmetic ingredient functioning as Surfactant–emulsifying, skin conditioning, solubilizing agent (bile salt). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 361-09-1 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant–emulsifying, skin conditioning, solubilizing agent (bile salt)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
sodium (4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
InChIKey
NRHMKIHPTBHXPF-TUJRSCDTSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; bile salts are also used in pharmaceutical applications as penetration enhancers
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Cholate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Cholate.
Known Synonyms
Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3-alpha,5-beta,7-alpha,12-alpha)-
EINECS 206-643-5
Trihydroxy 3-7-12 cholanate de Na
UNII-NU3Y4CCH8Z
Cholate
Chemical Function
Humectant
Softener and conditioner
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1421383
Frequently Asked Questions
Is Sodium Cholate allowed in the EU?
Sodium Cholate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Cholate do in cosmetics?
Sodium Cholate functions as: Surfactant–emulsifying, skin conditioning, solubilizing agent (bile salt). It is classified as a cosmetic ingredient in our database. CAS number: 361-09-1.
Is Sodium Cholate used outside cosmetics?
Sodium Cholate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Cholate compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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