Is Sodium Deoxycholate safe in cosmetics?
Sodium Deoxycholate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Sodium Deoxycholate
Also known as: 3-alpha,12-alpha-Dihydroxy-5-beta-cholan-24-oic acid sodium salt, EINECS 206-132-7, Sodium deoxycholic acid, Dihydroxy 3-12 cholanate de Na, Na-Desoxycholat (+4 more)
INCI: SODIUM DEOXYCHOLATE
Sodium Deoxycholate (CAS 302-95-4) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Emulsifying, Solubilizing (bile salt surfactant). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 302-95-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Emulsifying, Solubilizing (bile salt surfactant)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
sodium (4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
InChIKey
FHHPUSMSKHSNKW-SMOYURAASA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; also FDA-approved as pharmaceutical ingredient (Kybella®); cosmetic use range 0.1–2%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Deoxycholate.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =1050 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | =1370 mg/kg | Rat | oral | - | ChemIDplus |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Deoxycholate.
Known Synonyms
3-alpha,12-alpha-Dihydroxy-5-beta-cholan-24-oic acid sodium salt
EINECS 206-132-7
Sodium deoxycholic acid
Dihydroxy 3-12 cholanate de Na
Na-Desoxycholat
Natrium-3-alpha,12-alpha-dihydroxycholanat
UNII-436LS6U35Y
deoxycholate sodium
Deoxycholate
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1365278
Frequently Asked Questions
Is Sodium Deoxycholate allowed in the EU?
Sodium Deoxycholate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Deoxycholate do in cosmetics?
Sodium Deoxycholate functions as: Skin Conditioning, Emulsifying, Solubilizing (bile salt surfactant). It is classified as a cosmetic ingredient in our database. CAS number: 302-95-4.
Is Sodium Deoxycholate used outside cosmetics?
Sodium Deoxycholate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Deoxycholate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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