NOAEL Studies Cosmetic Ingredient

Sodium Diethylenetriamine Pentamethylene Phosphonate NOAEL Studies

INCI: SODIUM DIETHYLENETRIAMINE PENTAMETHYLENE PHOSPHONATE

CAS: 22042-96-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be519; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11192/7/9/3?documentUUID=8aebab54-7b26-45e4-b8e8-4a14fda34ca8; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15823747:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_475196967a5f439aa3615cf934202670
ToxValDB_ECHA_IUCLID NOAEL >=151 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8be4b0a7c65d1c9b6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11192/7/6/2?documentUUID=8aebab54-7b26-45e4-b8e8-4a14fda34ca8; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15847701:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c392f0b4a2e4142db16a8373eab458e4
ToxValDB_ECHA_IUCLID NOAEL >=195 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8be4b0a7c65d1c9b6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11192/7/6/2?documentUUID=8aebab54-7b26-45e4-b8e8-4a14fda34ca8; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15847717:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8659d94f71412eeda4ea3fa368f7ecf7
ToxValDB_ECHA_IUCLID NOAEL =92.3 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8be4b0a7c65d1c9b79; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11192/7/6/2?documentUUID=8aebab54-7b26-45e4-b8e8-4a14fda34ca8; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847861_15848510:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2734ef08b02a45860f83042b5a084df7
ToxValDB_ECHA_IUCLID NOAEL =82.5 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb86e4b0a7c65d226716; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15198/7/6/2?documentUUID=4562579a-3d48-45f2-8778-e1702cdd1cd4; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15848025_15848330:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_40a3e902dd43a647096430f080816f54
ToxValDB_HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOAEL =96 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de7e4b0a676289de547; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Hematology: RBC increase, MCV decrease, MCH decrease, HGB decrease, MCHC decrease|Absolute Organ Weight: Liver decrease; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|organ weight; STUDY_GROUP=HESS:15638098:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_842f5f0f8867f90dbe1e147b8df249e8
openFDA substances 40 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier E6DVO371LC UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.4Na.6H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E6DVO371LC"}
openFDA substances FDA UNII substance identifier IZ1NR8Y248 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.10Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZ1NR8Y248"}
openFDA substances FDA UNII substance identifier EB6X2O1D2Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.2Na.8H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EB6X2O1D2Y"}
openFDA substances FDA UNII substance identifier OP813V0J36 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.3Na.7H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OP813V0J36"}
openFDA substances FDA UNII substance identifier P6WC2P6QUK UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H27N3O15P5.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P6WC2P6QUK"}
openFDA substances FDA UNII substance identifier U5G2UPY323 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.6Na.4H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U5G2UPY323"}
openFDA substances FDA UNII substance identifier X747VDM3JV UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.9Na.H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X747VDM3JV"}
openFDA substances FDA UNII substance identifier OK9F2L7QZF UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.7Na.3H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OK9F2L7QZF"}
openFDA substances FDA UNII substance identifier 96V6W55893 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H23N3O15P5.5Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"96V6W55893"}
openFDA substances FDA UNII substance identifier 18U8CZB0SP UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.8Na.2H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"18U8CZB0SP"}
openFDA substances FDA UNII substance identifier E6DVO371LC UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.4Na.6H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E6DVO371LC"}
openFDA substances FDA UNII substance identifier E6DVO371LC UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.4Na.6H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E6DVO371LC"}
openFDA substances FDA UNII substance identifier IZ1NR8Y248 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.10Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZ1NR8Y248"}
openFDA substances FDA UNII substance identifier IZ1NR8Y248 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.10Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZ1NR8Y248"}
openFDA substances FDA UNII substance identifier EB6X2O1D2Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.2Na.8H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EB6X2O1D2Y"}
openFDA substances FDA UNII substance identifier EB6X2O1D2Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.2Na.8H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EB6X2O1D2Y"}
openFDA substances FDA UNII substance identifier OP813V0J36 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.3Na.7H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OP813V0J36"}
openFDA substances FDA UNII substance identifier OP813V0J36 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.3Na.7H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OP813V0J36"}
openFDA substances FDA UNII substance identifier P6WC2P6QUK UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H27N3O15P5.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P6WC2P6QUK"}
openFDA substances FDA UNII substance identifier P6WC2P6QUK UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H27N3O15P5.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P6WC2P6QUK"}
openFDA substances FDA UNII substance identifier U5G2UPY323 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.6Na.4H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U5G2UPY323"}
openFDA substances FDA UNII substance identifier U5G2UPY323 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.6Na.4H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U5G2UPY323"}
openFDA substances FDA UNII substance identifier E6DVO371LC UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.4Na.6H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E6DVO371LC"}
openFDA substances FDA UNII substance identifier IZ1NR8Y248 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.10Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZ1NR8Y248"}
openFDA substances FDA UNII substance identifier EB6X2O1D2Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.2Na.8H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EB6X2O1D2Y"}
openFDA substances FDA UNII substance identifier OP813V0J36 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.3Na.7H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OP813V0J36"}
openFDA substances FDA UNII substance identifier P6WC2P6QUK UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H27N3O15P5.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P6WC2P6QUK"}
openFDA substances FDA UNII substance identifier U5G2UPY323 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.6Na.4H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"U5G2UPY323"}
openFDA substances FDA UNII substance identifier X747VDM3JV UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.9Na.H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X747VDM3JV"}
openFDA substances FDA UNII substance identifier X747VDM3JV UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.9Na.H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X747VDM3JV"}
openFDA substances FDA UNII substance identifier OK9F2L7QZF UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.7Na.3H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OK9F2L7QZF"}
openFDA substances FDA UNII substance identifier OK9F2L7QZF UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.7Na.3H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OK9F2L7QZF"}
openFDA substances FDA UNII substance identifier 96V6W55893 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H23N3O15P5.5Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"96V6W55893"}
openFDA substances FDA UNII substance identifier 96V6W55893 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H23N3O15P5.5Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"96V6W55893"}
openFDA substances FDA UNII substance identifier 18U8CZB0SP UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.8Na.2H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"18U8CZB0SP"}
openFDA substances FDA UNII substance identifier 18U8CZB0SP UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.8Na.2H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"18U8CZB0SP"}
openFDA substances FDA UNII substance identifier X747VDM3JV UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.9Na.H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X747VDM3JV"}
openFDA substances FDA UNII substance identifier OK9F2L7QZF UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.7Na.3H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OK9F2L7QZF"}
openFDA substances FDA UNII substance identifier 96V6W55893 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H23N3O15P5.5Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"96V6W55893"}
openFDA substances FDA UNII substance identifier 18U8CZB0SP UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18N3O15P5.8Na.2H","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"18U8CZB0SP"}