NOAEL Studies
Cosmetic Ingredient
Sodium Diethylenetriamine Pentamethylene Phosphonate NOAEL Studies
INCI: SODIUM DIETHYLENETRIAMINE PENTAMETHYLENE PHOSPHONATE
CAS: 22042-96-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =82.5 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb86e4b0a7c65d226716; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15198/7/6/2?documentUUID=4562579a-3d48-45f2-8778-e1702cdd1cd4; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15848025_15848330:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_40a3e902dd43a647096430f080816f54 |
| ECHA | NOAEL | =92.3 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8be4b0a7c65d1c9b79; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11192/7/6/2?documentUUID=8aebab54-7b26-45e4-b8e8-4a14fda34ca8; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847861_15848510:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2734ef08b02a45860f83042b5a084df7 |
| ECHA | NOAEL | >=151 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8be4b0a7c65d1c9b6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11192/7/6/2?documentUUID=8aebab54-7b26-45e4-b8e8-4a14fda34ca8; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15847701:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c392f0b4a2e4142db16a8373eab458e4 |
| ECHA | NOAEL | >=195 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8be4b0a7c65d1c9b6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11192/7/6/2?documentUUID=8aebab54-7b26-45e4-b8e8-4a14fda34ca8; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15847717:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8659d94f71412eeda4ea3fa368f7ecf7 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be519; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11192/7/9/3?documentUUID=8aebab54-7b26-45e4-b8e8-4a14fda34ca8; YEAR=1972; ORIGINAL_YEAR=1972; STUDY_GROUP=ECHA IUCLID:15823747:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_475196967a5f439aa3615cf934202670 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOAEL | =96 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de7e4b0a676289de547; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Hematology: RBC increase, MCV decrease, MCH decrease, HGB decrease, MCHC decrease|Absolute Organ Weight: Liver decrease; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|organ weight; STUDY_GROUP=HESS:15638098:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_842f5f0f8867f90dbe1e147b8df249e8 |
openFDA substances 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 18U8CZB0SP | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | 96V6W55893 | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | E6DVO371LC | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | EB6X2O1D2Y | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | IZ1NR8Y248 | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | OK9F2L7QZF | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | OP813V0J36 | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | P6WC2P6QUK | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | U5G2UPY323 | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | X747VDM3JV | UNII | - | - | - | chemical | - |