Sodium Dodoxynol-40 Sulfate

INCI: SODIUM DODOXYNOL-40 SULFATE

CAS Number
Not publicly assigned
Function
Surfactant — cleansing, emulsifying (ethoxylated alkylphenol sulfate salt)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted; part of the alkylphenol ethoxylate sulfate family

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Alkylphenol ethoxylate (APE) class concern — nonylphenol/dodecylphenol ethoxylates are under regulatory scrutiny in the EU for endocrine disruption; potential environmental persistence. Ethoxylation process introduces 1,4-dioxane and ethylene oxide residual risk — COA verification mandatory

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Concern Level: Moderate

Frequently Asked Questions

Is Sodium Dodoxynol-40 Sulfate safe in cosmetics?

Alkylphenol ethoxylate (APE) class concern — nonylphenol/dodecylphenol ethoxylates are under regulatory scrutiny in the EU for endocrine disruption; potential environmental persistence. Ethoxylation process introduces 1,4-dioxane and ethylene oxide residual risk — COA verification mandatory The EU classifies Sodium Dodoxynol-40 Sulfate as "permitted". Safety rating: MODERATE.

Is Sodium Dodoxynol-40 Sulfate allowed in the EU?

Sodium Dodoxynol-40 Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Dodoxynol-40 Sulfate do in cosmetics?

Sodium Dodoxynol-40 Sulfate functions as: Surfactant — cleansing, emulsifying (ethoxylated alkylphenol sulfate salt). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned.

What is the Margin of Safety for Sodium Dodoxynol-40 Sulfate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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