NOAEL Studies Cosmetic Ingredient

Sodium Fumarate NOAEL Studies

INCI: SODIUM FUMARATE

CAS: 17013-01-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR_vision_codex 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR_vision_codex NOAEL =500 mg/kg rabbit intravenous 10-32 days kidney and liver function {"citation":"0","dose":"50-500 mg/kg","effect":"no injurious effect on blood levels of non-protein nitrogen or creatinine, phenosulfolphthalein excretion, or kidney and liver histology","page":8,"pdf":"FR464.pdf","row_type":"noael_study","study_id":"Bodansky_1942_Sodium_Fumarate_IV"}
CIR_vision_codex NOAEL =6.9 % in diet rabbit oral 150 days general toxicity, spermatogenesis, testicular structure {"citation":"0","dose":"6.9% in diet (equivalent to 5% Fumaric Acid)","effect":"no significant differences from controls in body weight gain, feed consumption, mortality rate, blood counts, blood sugar, non-protein nitrogen level and urine; spermatogenesis and testicular structure were unaffected","page":8,"pdf":"FR464.pdf","row_type":"noael_study","study_id":"Packman_1963_Sodium_Fumarate_Oral"}
CIR_vision_codex NOAEL =500 mg/kg rabbit intravenous 10-32 days kidney and liver function {"citation":"0","dose":"50-500 mg/kg","effect":"no injurious effect on blood levels of non-protein nitrogen or creatinine, phenosulfolphthalein excretion, or kidney and liver histology","page":8,"pdf":"FR464.pdf","row_type":"noael_study","study_id":"Bodansky_1942_Sodium_Fumarate_IV"}
CIR_vision_codex NOAEL =6.9 % in diet rabbit oral 150 days general toxicity, spermatogenesis, testicular structure {"citation":"0","dose":"6.9% in diet (equivalent to 5% Fumaric Acid)","effect":"no significant differences from controls in body weight gain, feed consumption, mortality rate, blood counts, blood sugar, non-protein nitrogen level and urine; spermatogenesis and testicular structure were unaffected","page":8,"pdf":"FR464.pdf","row_type":"noael_study","study_id":"Packman_1963_Sodium_Fumarate_Oral"}
CIR_vision_codex NOAEL =500 mg/kg rabbit intravenous 10-32 days kidney and liver function {"citation":"0","dose":"50-500 mg/kg","effect":"no injurious effect on blood levels of non-protein nitrogen or creatinine, phenosulfolphthalein excretion, or kidney and liver histology","page":8,"pdf":"FR464.pdf","row_type":"noael_study","study_id":"Bodansky_1942_Sodium_Fumarate_IV"}
CIR_vision_codex NOAEL =6.9 % in diet rabbit oral 150 days general toxicity, spermatogenesis, testicular structure {"citation":"0","dose":"6.9% in diet (equivalent to 5% Fumaric Acid)","effect":"no significant differences from controls in body weight gain, feed consumption, mortality rate, blood counts, blood sugar, non-protein nitrogen level and urine; spermatogenesis and testicular structure were unaffected","page":8,"pdf":"FR464.pdf","row_type":"noael_study","study_id":"Packman_1963_Sodium_Fumarate_Oral"}
CIR_vision_codex NOAEL =500 mg/kg rabbit intravenous 10-32 days kidney and liver function {"citation":"0","dose":"50-500 mg/kg","effect":"no injurious effect on blood levels of non-protein nitrogen or creatinine, phenosulfolphthalein excretion, or kidney and liver histology","page":8,"pdf":"FR464.pdf","row_type":"noael_study","study_id":"Bodansky_1942_Sodium_Fumarate_IV"}
CIR_vision_codex NOAEL =6.9 % in diet rabbit oral 150 days general toxicity, spermatogenesis, testicular structure {"citation":"0","dose":"6.9% in diet (equivalent to 5% Fumaric Acid)","effect":"no significant differences from controls in body weight gain, feed consumption, mortality rate, blood counts, blood sugar, non-protein nitrogen level and urine; spermatogenesis and testicular structure were unaffected","page":8,"pdf":"FR464.pdf","row_type":"noael_study","study_id":"Packman_1963_Sodium_Fumarate_Oral"}
openFDA substances 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0578QTK490 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H2O4.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0578QTK490"}
openFDA substances FDA UNII substance identifier 0578QTK490 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H2O4.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0578QTK490"}
openFDA substances FDA UNII substance identifier 0578QTK490 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H2O4.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0578QTK490"}