NOAEL Studies
Cosmetic Ingredient
Sodium Iodide NOAEL Studies
INCI: SODIUM IODIDE
CAS: 7681-82-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ATSDR_toxval_ATSDR_MRLs.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ATSDR_toxval_ATSDR_MRLs.xlsx | NOAEL | =0.01 | mg/kg/day | Human (M/F) | oral | short-term; 14 days | clinical | ATSDR MRLs; row_hash=ddd67a67a3616dc0; source_hash=ToxValhc_591ef64e4d12a71938779142b92d1269; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=0.01; raw_unit=mg/kg/day; effect=endocrine; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Gardner DF, Centor RM, Utiger RD. 1988. Effects of low dose oral iodide supplementation on thyroid function in normal men. Clin Endocrinol 28:283-288; Paul T, Meyers B, Witorsch RJ, et al. 1988. The effect of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism 37(2):121-124.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585797 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14580; RecordID=ARPathway2016_1545; DatasetName=ARPathway2016; DTXSID=DTXSID2041125; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041125 |
ToxValDB_ATSDR_MRLs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ATSDR_MRLs | NOAEL | =0.01 | mg/kg bw/day | Human | oral | short-term; 14 days | clinical | LONG_REF=Gardner DF, Centor RM, Utiger RD. 1988. Effects of low dose oral iodide supplementation on thyroid function in normal men. Clin Endocrinol 28:283-288; Paul T, Meyers B, Witorsch RJ, et al. 1988. The effect of small increases in dietary iodine on thyroid function in euthyroid subjects. Metabolism 37(2):121-124.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585797; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp158.pdf; TOXICOLOGICAL_EFFECT=endocrine; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447676:M/F:-adult; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_591ef64e4d12a71938779142b92d1269 |
ToxValDB_ECHA_IUCLID 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =0.6 | mg/L | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d216e4b0a7c65d2318dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15294/7/9/3?documentUUID=9fc0ea78-8834-461f-84d8-ef1bcaeb4724; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=maternal: histopathology: non-neoplastic|maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15823056:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4334aa4c8b035c921577249ed9ac8297 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =3.7 | MBq | Rat | injection | short-term; 2 days | short-term | LONG_REF=Indian J. Med. Res.122(4): 338-342 Dani,V., and D.K. Dhawan Radioprotective Role of Zinc Following Single Dose Radioiodine (131I) Exposure to Red Blood Cells of Rats 2005; TITLE=Radioprotective Role of Zinc Following Single Dose Radioiodine (131I) Exposure to Red Blood Cells of Rats; AUTHOR=Dani,V., and D.K. Dhawan; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97394; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Biochemistry: Malondialdehyde|Enzyme(s): Catalase|Enzyme(s): Glutathione reductase|Enzyme(s): Superoxide dismutase (SOD) enzyme activity; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15594908:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8496b83fefae09c5c9fedebe1834f873 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.822 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634827:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87c89050295ef09fd726580e468b13e0 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | F5WR8N145C | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"I.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F5WR8N145C"} |
| openFDA substances | FDA UNII substance identifier | F5WR8N145C | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"I.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F5WR8N145C"} |
| openFDA substances | FDA UNII substance identifier | F5WR8N145C | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"I.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F5WR8N145C"} |
| openFDA substances | FDA UNII substance identifier | F5WR8N145C | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"I.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F5WR8N145C"} |