Is Sodium Iodide safe in cosmetics?
Sodium Iodide has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Sodium Iodide
Also known as: NaI, Sodium iodide (NaI), Caswell No. 777, EINECS 231-679-3, EPA Pesticide Chemical Code 075702 (+2 more)
INCI: SODIUM IODIDE
Sodium Iodide (CAS 7681-82-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; antimicrobial (limited cosmetic use). NOAEL 0.01 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7681-82-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium Iodide is classified GHS Danger (H315, H319, H335, H372, H400, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning agent; antimicrobial (limited cosmetic use)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
sodium iodide
InChIKey
FVAUCKIRQBBSSJ-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not widely reported in cosmetic formulations per VCRP
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Iodide.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Ingestion may cause effects on the thyroid. May cause systemic sensitization. See Notes.
Routes of Exposure
The substance can be absorbed into the body by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Iodide across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1009
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Iodide.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Iodide by CAS number or substance name.
Studies
6
Lowest NOAEL
0.01 mg/kg bw/day
Highest NOAEL
160 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
NaI
Sodium iodide (NaI)
Caswell No. 777
EINECS 231-679-3
EPA Pesticide Chemical Code 075702
Jodid sodny
UNII-F5WR8N145C
Chemical Function
Biocide
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
Europe; supplements
Europe; food_additive; supplements
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SODIUM IODIDE
ChEMBL ID
CHEMBL1644695
Max Phase
4
Adverse Event Associations
236
Frequently Asked Questions
Is Sodium Iodide allowed in the EU?
Sodium Iodide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Iodide do in cosmetics?
Sodium Iodide functions as: Skin conditioning agent; antimicrobial (limited cosmetic use). It is classified as a cosmetic ingredient in our database. CAS number: 7681-82-5.
Is Sodium Iodide used outside cosmetics?
Sodium Iodide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium Iodide have different safety status in cosmetics vs industrial chemicals?
Sodium Iodide is classified GHS Danger (H315, H319, H335, H372, H400, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Sodium Iodide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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NATAMYCIN
Good
Chemical family
Antimicrobial, Preservative
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Chemical family
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